A5061724321- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Cardiac Imaging and Diagnostics
- Ultrasound and Cavitation Phenomena
- Ultrasound Imaging and Elastography
- Genetics and Neurodevelopmental Disorders
- Cannabis and Cannabinoid Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Electron Spin Resonance Studies
- Pancreatic function and diabetes
- Cardiac Arrhythmias and Treatments
- Virus-based gene therapy research
- Advanced NMR Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Microbial Inactivation Methods
- Viral Infections and Immunology Research
- Thermal Regulation in Medicine
- Pluripotent Stem Cells Research
- Cardiac electrophysiology and arrhythmias
- Optical Imaging and Spectroscopy Techniques
- Motor Control and Adaptation
- Viral Infectious Diseases and Gene Expression in Insects
Siemens Healthcare (United States)
2024
Siemens (France)
2014-2019
Siemens Healthcare (Germany)
2017
Centre National de la Recherche Scientifique
2005-2015
Electrophysiology and Heart Modeling Institute
2015
Université de Bordeaux
2006-2015
Centre de Résonance Magnétique des Systèmes Biologiques
2014
University of Geneva
2008-2012
University Hospital of Geneva
2007-2009
Infection et inflammation
2006
There is a crucial need for noninvasive assessment tools after cell transplantation. This study investigates whether magnetic resonance imaging (MRI) strategy could be clinically applied to islet The purest fractions of seven human preparations were labeled with superparamagnetic iron oxide particles (SPIO, 280 microg/mL) and transplanted into four patients type 1 diabetes. MRI studies (T2*) performed prior at various time points Viability in vitro vivo functions islets similar those control...
Clinical treatment of cardiac arrhythmia by radiofrequency ablation (RFA) currently lacks quantitative and precise visualization lesion formation in the myocardium during procedure. This study aims at evaluating thermal dose (TD) imaging obtained from real-time magnetic resonance (MR) thermometry on heart as a relevant indicator extent. MR temperature mapping based Proton Resonance Frequency Shift (PRFS) method was performed 1.5 T heart, with 4 to 5 slices acquired per heartbeat. Respiratory...
Abstract Purpose To evaluate the feasibility and precision of magnetic resonance imaging (MRI) thermometry for monitoring radiofrequency (RF) liver ablation in vivo predicting size zone. Materials Methods At 1.5T, respiratory‐triggered real‐time MR temperature mapping (the proton frequency (PRF) method) was used to monitor RF rabbit ( N = 6) under free breathing. The zones, as assessed by histological analyses, compared with that predicted from thermal dose (TD) maps or derived conventional...
Purpose The therapy endpoint most commonly used in MR‐guided high intensity focused ultrasound is the thermal dose. Although namely correlated with nonviable tissue, it does not account for changes mechanical properties of tissue during ablation. This study presents a new acquisition sequence multislice, subsecond and simultaneous imaging temperature displacement Methods A single‐shot echo planar was implemented using pair motion‐encoding gradients, alternated polarities. first pulse...
A new real-time MR-thermometry pipeline was developed to measure multiple temperature images per heartbeat with 1.6×1.6×3 mm3 spatial resolution. The method evaluated on 10 healthy volunteers and during radiofrequency ablation (RFA) in sheep.Multislice, electrocardiogram-triggered, echo-planar imaging combined parallel imaging, under free breathing conditions. In-plane respiratory motion corrected magnitude by an optical flow algorithm. Motion-related susceptibility artifacts were...
Abstract The purpose of this work was to validate in phantom studies and demonstrate the clinical feasibility MR proton resonance frequency thermometry at 1.5 T with segmented gradient‐echo echo planar imaging (GRE‐EPI) sequences during liver tumour radiofrequency (RF) ablation. Classical GRE acquisitions GRE‐EPI were performed simultaneous RF heating an MR‐compatible electrode placed agar gel phantom. Temperature increments calculated compared four optical temperature probe measurements...
Abstract MR‐thermometry allows monitoring of the local temperature evolution during minimally invasive interventional therapies. However, for particular case in human breast, magnetic field variations induced by respiratory cycle lead to phase fluctuations requiring a suitable correction strategy prevent thermometry errors. For this purpose look‐up‐table‐based multibaseline approach as well model‐based algorithm were applied correct periodic changes. The proposed method is compatible with...
Ex vivo labeling of islets with superparamagnetic iron oxide (SPIO) nanoparticles allows posttransplant MRI imaging the graft. In present study, we compare two clinical grade SPIOs (ferucarbotran and ferumoxide) in terms toxicity, islet cellular uptake, imaging. Human (80–90% purity) were incubated for 24 h various concentrations (14–280 μg/ml iron). Static incubations performed, comparing insulin response to basal (2.8 mM) or high glucose stimulation (16.7 mM), without cAMP stimulation....
Pluripotent stem cell-seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2-primed cardiac-committed mouse embryonic cells, embedded into biodegradable fibrin matrices and engrafted onto rat For vivo tracking the superparamagnetic iron oxide nanoparticles were magnetofected thus enabling detection functional evaluation by high-resolution magnetic resonance imaging. Six weeks after...
There is an increasing interest in developing novel imaging strategies for sensing proteolytic activities intact organisms vivo . Overhauser‐enhanced MRI (OMRI) offers the possibility to reveal proteolysis of nitroxide‐labeled macromolecules thanks a sharp decrease rotational correlation time nitroxide moiety upon cleavage. In this paper, concept illustrated at 0.2 T using elastin orally administered mice. vitro , derivative was OMRI‐visible and gave rise high Overhauser enhancements...
The purpose of this study was to measure regional contractile function in the normal rat using cardiac cine and tagged cardiovascular magnetic resonance (CMR) during incremental low doses dobutamine at rest. Five rats were investigated for invasive left ventricle pressure measurements five additional imaged on a clinical 1.5 T MR system sequence (11–20 phases per cycle, 0.28/0.28/2 mm) C-SPAMM tag (18–25 0.63/1.79/3 mm, spacing 1.25 mm). For each slice, wall thickening (WT) circumferential...
A method is presented to obtain temperature and longitudinal relaxivity measurements simultaneously in near real-time. Quantitative values are obtained from the signal magnitude fast Look-Locker EPI data, whereas phase information all samples on recovery curve combined provide using proton resonance frequency method. The utility of this technique illustrated an vitro experiment with thermosensitive liposomes, which studied as potential micro vehicles for local drug delivery. allowed...
Abstract Background Magnetic resonance (MR) thermometry allows visualization of lesion formation in real‐time during cardiac radiofrequency (RF) ablation. The present study was performed to evaluate the precision MR without RF heating patients exhibiting arrhythmia a clinical setting. evaluation relied on quantification changes temperature measurements caused by noise and physiological motion. Methods Fourteen referred for cardiovascular magnetic imaging underwent an extra sequence test...
The use of magnetic resonance (MR) thermometry for the monitoring thermal ablation is rapidly expanding. However, this technique remains challenging treatment cardiac arrhythmia by radiofrequency due to heart displacement with respiration and contraction. Recent studies have addressed problem compensating in-plane motion in real-time optical-flow based tracking technique. these algorithms are sensitive local variation signal intensity on magnitude images associated tissue heating. In study,...
// Pierre-Yves Fortin 1, 2 , Matthieu Lepetit-Coiffé 1 Coralie Genevois Christelle Debeissat Bruno Quesson Chrit T.W. Moonen Jan Pieter Konsman 3 Franck Couillaud Laboratoire d’Imagerie Moléculaire et Fonctionnelle (IMF), CNRS/UMR 5231, Université de Bordeaux, France Institut Bio-Imagerie (IBIO), CNRS/UMS 3428, Centre Résonance Magnétique des Systèmes Biologiques (RMSB), 5536, Correspondence to: Couillaud, e-mail: franck.couillaud@u-bordeaux.fr...