A5100774896- Traumatic Brain Injury and Neurovascular Disturbances
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Anesthesia and Pain Management
- Optical Imaging and Spectroscopy Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Pelvic and Acetabular Injuries
- Trauma and Emergency Care Studies
- Teratomas and Epidermoid Cysts
- Congenital Anomalies and Fetal Surgery
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Congenital gastrointestinal and neural anomalies
- Abdominal Surgery and Complications
- Tumors and Oncological Cases
- Spinal Fractures and Fixation Techniques
- Sepsis Diagnosis and Treatment
- Neurosurgical Procedures and Complications
Mubarak Al Kabeer Hospital
2024
Sir Ganga Ram Hospital
2024
Addenbrooke's Hospital
2009-2023
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2008-2023
Institute of Medical Sciences
2003-2023
Vardhman Mahavir Medical College & Safdarjung Hospital
2020-2023
Jai Prakash Vishwavidyalaya
2022-2023
Sawai ManSingh Medical College and Hospital
1992-2022
Post Graduate Institute of Medical Education and Research
2015-2022
Rabindranath Tagore Medical College
2017-2022
Background The invasive nature of the current methods for monitoring intracranial pressure (ICP) has prevented their use in many clinical situations. Several attempts have been made to develop monitor ICP non-invasively. aim this study is assess relationship between ultrasound-based non-invasive (nICP) and measurement neurocritical care patients. Methods findings This was a prospective, single-cohort observational patients admitted tertiary unit. Patients with brain injury requiring were...
To use a range of techniques to explore diffusion limitation as mechanism cellular hypoxia in the setting head injury.A prospective interventional study.A specialist neurocritical care unit.Thirteen patients within 7 days closed injury underwent imaging studies. Tissue for ultrastructural studies was obtained from cohort seven who required surgery.Cerebral tissue PO2 (PtO2) using multiple-variable sensor, and images oxygen extraction fraction (OEF), derived positron emission tomography, were...
Objective To investigate the effect of hyperventilation on cerebral blood flow in traumatic brain injury. Design A prospective interventional study. Setting specialist neurocritical care unit. Patients Fourteen healthy volunteers and 33 patients within 7 days closed head Interventions All subjects underwent positron emission tomography imaging flow. In patients, Paco2 was reduced from 36 ± 1 to 29 torr (4.8 0.1 3.9 kPa) measurements repeated. Jugular venous saturation (Sjvo2) arteriovenous...
Object Decompressive craniectomy is an advanced treatment option for intracranial pressure (ICP) control in patients with traumatic brain injury. The purpose of this study was to evaluate the effect decompressive on ICP and cerebrospinal compensation both within beyond first 24 hours craniectomy. Methods This a retrospective analysis physiological parameters from 27 moderately severely head-injured who underwent progressive edema. Of these, 17 had undergone prospective digital recording...
This study comprises 60 cases of tuberculous meningitis including both adults and children. Only three showed a normal scan. Severe hydrocephalus was present in 87.09% children only 12.09% adults. The incidence increased with the duration illness decreased age. Exudates basal cisterns were graded from mild to severe, latter being seen Visible infarcts shown 28.33% cases, 10% associated parenchymal tuberculomas. Serial follow-up scans indicate that patients non-enhancing exudates have good...
To determine the effect of normobaric hyperoxia on cerebral metabolism in patients with severe traumatic brain injury.Prospective clinical investigation.Neurosciences critical care unit a university hospital.Eleven injury.Cerebral microdialysis, tissue oximetry (PbO2), and oxygen-15 positron emission tomography (15O-PET) were undertaken at normoxia repeated (FiO2 increase between 0.35 0.50).Established models used to image blood flow, volume, oxygen metabolism, extraction fraction....
To compare the effect of 800 vs 400 IU daily oral vitamin D3 on prevalence D deficiency (VDD) at 40 weeks' postmenstrual age (PMA) in preterm infants 28 to 34 gestation.In this randomized double-blind trial, we allocated eligible receive either or per day (n = 48 both groups). Primary outcome was VDD (serum 25-hydroxyvitamin levels <20 ng/mL) PMA. Secondary outcomes were VDD, bone mineral content, and density 3 months' corrected (CA).Prevalence 800-IU group significantly lower than 400-IU...
Acanthamoeba was implicated as the causative agent of chronic meningitis in three apparently immunocompetent children. Diagnosis established by cerebrospinal fluid wet mount examination and culture. Two children improved rapidly with combination oral therapy composed trimethoprim-sulfamethoxazole, rifampin ketoconazole.
Objectives: We sought to characterize 1) the difference in diffusion gradient of cellular oxygen delivery and 2) presence limitation physiology hypoxic-ischemic brain injury patients with hypoxia, as defined by parenchymal tissue tension less than 20 mm Hg versus normoxia (brain > Hg). Design: Post hoc subanalysis a prospective study dichotomized into those hypoxia normoxia. Setting: Quaternary ICU. Patients: Fourteen adult after cardiac arrest. Interventions: Patients underwent...
Metabolic derangements following traumatic brain injury are poorly characterized. In this single-centre observational cohort study we combined 18F-FDG and multi-tracer oxygen-15 PET to comprehensively characterize the extent spatial pattern of metabolic derangements. Twenty-six patients requiring sedation ventilation with intracranial pressure monitoring head within a Neurosciences Critical Care Unit, 47 healthy volunteers were recruited. Eighteen excluded for age over 60 years (n = 11),...
Abstract Incidence of non-communicable diseases (NCDs) such as diabetes and obesity is on the rise worldwide. Rising consumption ultra-processed food (UPF) products or those high in fats, sugars salt also called junk foods contributes to this grave situation. Increasing UPFs associated with obesity, type-2 diabetes, cardiovascular disease, cancers, cerebral vascular disease all-cause mortality. Aggressive pervasive marketing targeting children adolescents leads development preference for...
Object. The aim of this study was to investigate potential episodes cerebral ischemia during surgery for large and complicated aneurysms, by examining the effects arterial temporary clipping impact confounding variables such as blood pressure cerebrospinal fluid (CSF) drainage. Methods. Brain tissue PO 2 , PCO pH, well temperature extracellular glucose, lactate, pyruvate, glutamate were monitored in 46 patients using multiparameter sensors microdialysis. Baseline data showed that brain...
For patients undergoing craniotomy, it is desirable to have stable and easily controllable hemodynamics during intense surgical stimulation. However, rapid postoperative recovery essential assess neurologic function. Remifentanil, an ultra-short-acting μ-opioid receptor agonist, may be the ideal agent confer above characteristics. In this prospective randomized study, we compared hemodynamic stability, characteristics, dose of propofol required for maintaining anesthesia supplemented with...
The ability to measure brain tissue chemistry has led valuable information regarding pathophysiological changes in patients with traumatic injury (TBI). Over the last few years, focus been on monitoring oxygen determine thresholds of ischemia that affect outcome. However, variability this measurement suggests it may not be a robust method. We have therefore investigated relationship pH (pHb) and outcome TBI. retrospectively analyzed prospectively collected data 38 admitted Neurosciences...
The effects of hypoxemia on the cerebral vasculature have been described in animal models, but data from human studies are limited and often relied invasive methodology.The ability to detect a threshold for hypoxic vasodilatation humans may be clinically useful, particularly patients with impaired intracranial compliance. Because physiology differ among subjects, it would advantageous measure such thresholds using noninvasive bedside techniques that could readily applied individual patients....
The aim of the study was to monitor brain metabolism during aneurysm clipping using microdialysis and multiparameter sensors, particularly investigate effects temporary vessels. Microdialysis catheters (n= 10) Paratrend (02, C02, pH temperature) sensors (n = 15) were inserted into cerebral cortex via a specially designed triple bolt prior craniotomy. Baseline 02 levels ranging from 15-45 mmHg (2.0-6.0 kPa) glucose 0.5-3 mmol l~1 stable uneventful periods. mean lactate/pyruvate (L/P) ratio...