A5028341906- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes Management and Research
- Diabetes Treatment and Management
- Anesthesia and Pain Management
- Enhanced Recovery After Surgery
- Intensive Care Unit Cognitive Disorders
- Nausea and vomiting management
- Pain Management and Opioid Use
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Sepsis Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Traumatic Brain Injury and Neurovascular Disturbances
- Bariatric Surgery and Outcomes
- Cardiac and Coronary Surgery Techniques
- Diet and metabolism studies
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Venous Thromboembolism Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Acute Myocardial Infarction Research
- Hemodynamic Monitoring and Therapy
- Meta-analysis and systematic reviews
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2018-2025
Public Health Service of Amsterdam
2022-2024
Vrije Universiteit Amsterdam
2024
Academic Medical Center
2012-2023
University of Cambridge
2018-2021
Addenbrooke's Hospital
2018
Catharina Ziekenhuis
2018
Radboud University Nijmegen
2018
Diakonessenhuis hospital
2012
Mounting evidence suggests a role for glucose variability in predicting intensive care unit (ICU) mortality. We investigated the association between and in-hospital deaths across several ranges of mean glucose.Retrospective cohort study.An 18-bed medical/surgical ICU teaching hospital.All patients admitted to from January 2004 through December 2007.None.Two measures variability, absolute change per hour sd, were calculated as 5728 related death using logistic regression analysis. Mortality...
The implementation of intensive insulin therapy in the care unit is accompanied by an increase hypoglycemia. We studied relation between hypoglycemia on mortality, because evidence this subject conflicting.Retrospective database cohort study.An 18-bed medical/surgical a teaching hospital (Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, Netherlands).A total 5961 patients admitted to from 2004 2007 were analyzed. Readmissions and with withholding policy or first glucose measurement excluded....
To investigate the efficacy of sensor-augmented pump therapy vs. multiple daily injection in patients with suboptimally controlled Type 1 diabetes.In this investigator-initiated multi-centre trial (the Eurythmics Trial) eight outpatient centres Europe, we randomized 83 diabetes (40 women) currently treated injections, age 18-65 years and HbA(1c) ≥ 8.2% (≥ 66 mmol/mol) to 26 weeks treatment either a insulin (n = 44) (Paradigm(®) REAL-Time) or continued injections 39). Change between baseline...
In critical illness, four measures of glycaemic control are associated with ICU mortality: mean glucose concentration, variability, the incidence hypoglycaemia (≤2.2 mmol/l) or low (2.3 to 4.7 mmol/l). Underlying diabetes mellitus (DM) might affect these associations. Our objective was study whether association between and mortality differs patients without DM explore cutoff value for detrimental in both cohorts.This retrospective database cohort included admitted January 2004 June 2011 a...
Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most complex gastrointestinal endoscopic procedures. Currently, it still unclear which sedation regimen best facilitates an ERCP. The N-methyl-D-aspartate receptor antagonist esketamine has anaesthetic, analgesic and sympathomimetic properties known to cause less cardiorespiratory depression than other sedatives. It could therefore be ideal adjunct propofol for deep sedation.To assess effectiveness versus alfentanil as...
Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i's) were shown reduce hospitalization and stress. However, how inflammation causes cells, SGLT2i's can this is unknown. Here we hypothesized that 1) TNF-α activates the Na+/H+ exchanger (NHE) raises cytoplasmatic Na+ ([Na+]c), 2) increased [Na+]c reactive oxygen species (ROS) production, 3) empagliflozin (EMPA) reduces inflammation-induced ROS...
The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and moderate TBI who deteriorate require admission the intensive care unit for intracranial pressure (ICP) management.
Traumatic brain injury (TBI) is a major public health concern with significant consequences across various domains. Following the primary event, secondary injuries compound outcome after TBI, disrupted glucose metabolism emerging as relevant factor. This narrative review summarises existing literature on post-TBI alterations in metabolism. After undergoes dynamic changes transport, including transporters and kinetics, disruptions blood-brain barrier (BBB). In addition, cerebral transitions...
Vascular inflammation and disturbed metabolism are observed in heart failure type 2 diabetes mellitus. Glycolytic enzyme hexokinase II (HKII) is upregulated by inflammation. We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces via HKII endothelial cells, HKII-dependent determined ERK1/2, NF-κB. and/or AMPK activity lipopolysaccharide (LPS)-stimulated human coronary artery cells (HCAECs).HCAECs were pre-incubated with 3 μM 10 Cana, 1...
SGLT-2i’s exert direct anti-inflammatory and anti-oxidative effects on resting endothelial cells. However, cells are constantly exposed to mechanical forces such as cyclic stretch. Enhanced stretch increases the production of reactive oxygen species (ROS) thereby impairs barrier function. We hypothesized that empagliflozin (EMPA), dapagliflozin (DAPA) canagliflozin (CANA) an effect alleviate stretch-induced permeability in human coronary artery (HCAECs). HCAECs were pre-incubated with one (1...
Abstract Introduction Lowering of hyperglycemia in the intensive care unit (ICU) is widely practiced. We investigated which way glucose regulation, defined as mean concentration during admission, associated with ICU mortality a medical and surgical cohort. Methods Retrospective database cohort study including patients admitted between January 2004 December 2007 20-bed medical/surgical teaching hospital. Hyperglycemia was treated using computerized algorithm targeting for levels 4.0-7.0...
To investigate the relation between perioperative hyperglycemia and complications after pancreatoduodenectomy.Perioperative is associated with various types of surgery. This was never investigated for pancreatoduodenectomy.In a consecutive series 330 patients undergoing pancreatoduodenectomy, glucose values were collected from hospital information system during 3 periods: pre-, intra-, early postoperative. The average value per period calculated each patient divided in duals according to...