A5078516494- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Intensive Care Unit Cognitive Disorders
- Clinical Nutrition and Gastroenterology
- Diabetes Treatment and Management
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Electrolyte and hormonal disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Vitamin C and Antioxidants Research
- Respiratory Support and Mechanisms
- Diet and metabolism studies
- Diabetes and associated disorders
- COVID-19 and healthcare impacts
- Nosocomial Infections in ICU
- Gastrointestinal motility and disorders
- Acute Kidney Injury Research
- Transplantation: Methods and Outcomes
- Hip and Femur Fractures
- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Opioid Use Disorder Treatment
The University of Adelaide
2013-2025
The Royal Melbourne Hospital
2018-2025
Royal Adelaide Hospital
2013-2025
The University of Melbourne
2018-2024
Austin Hospital
2023
College of Intensive Care Medicine
2022
Yale Cancer Center
2022
National Health and Medical Research Council
2022
October 6 University
2021
Yale University
2021
Objectives: Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. However, comparison placebo has been inadequately evaluated, and pantoprazole the potential cause harm. Our objective was evaluate benefit or harm associated with administration. Design: Prospective randomized double-blind parallel-group study. Setting: University-affiliated mixed medical-surgical ICU. Patients: Mechanically ventilated suitable enteral nutrition....
Objectives To describe the characteristics and outcomes of patients with COVID-19 admitted to intensive care units (ICUs) during initial months pandemic in Australia. Design, setting Prospective, observational cohort study 77 ICUs across Participants Patients participating laboratory-confirmed 27 February – 30 June 2020. Main outcome measures ICU mortality resource use (ICU length stay, peak bed occupancy). Results The median age 204 was 63.5 years (IQR, 53–72 years); 140 were men (69%)....
Traumatic brain injury (TBI) is a major public health concern with significant consequences across various domains. Following the primary event, secondary injuries compound outcome after TBI, disrupted glucose metabolism emerging as relevant factor. This narrative review summarises existing literature on post-TBI alterations in metabolism. After undergoes dynamic changes transport, including transporters and kinetics, disruptions blood-brain barrier (BBB). In addition, cerebral transitions...
Objective Stress induced hyperglycemia occurs in critically ill patients who have normal glucose tolerance following resolution of their acute illness. The objective was to evaluate the association between stress and incident diabetes survivors critical Design Retrospective cohort study. Setting All adult surviving admission a public hospital intensive care unit (ICU) South Australia 2004 2011. Patients defined as blood ≥ 11.1 mmol/L (200 mg/dL) within 24 hours ICU admission. Prevalent...
Objective To compare the demographic and clinical features, management, outcomes for patients admitted with COVID-19 to intensive care units (ICUs) during first, second, third waves of pandemic in Australia. Design, setting, participants People aged 16 years or more polymerase chain reaction-confirmed 78 Australian ICUs participating Short Period Incidence Study Severe Acute Respiratory Infection (SPRINT-SARI) Australia project first (27 February – 30 June 2020), second (1 July 2020 25...
The optimal blood glucose target in critically ill patients with preexisting diabetes and chronic hyperglycemia is unknown. In such patients, we aimed to determine whether a " liberal" approach glycemic control would reduce hypoglycemia variability appear safe.Prospective, open-label, sequential-period exploratory study.Medical-surgical ICU.During sequential 6-month periods, studied 83 type 2 (glycated hemoglobin, ≥ 7.0% at ICU admission).During the "standard care" period, 52 received...
Abstract Lymphopenia is a common feature of acute COVID-19 and associated with increased disease severity 30-day mortality. Here we aim to define the demographic clinical characteristics that correlate lymphopenia in determine if an independent predictor poor outcome. We analysed ENTER-COVID (Epidemiology hospitalized in-patient admissions following planned introduction Epidemic SARS-CoV-2 highly vaccinated naïve population) dataset adults (N = 811) admitted for treatment South Australia...
To describe and compare the demographics, management, outcomes for patients with COVID-19 admitted to intensive care units (ICUs) in Australia across various waves of COVID pandemic. People aged ≥16 years who were a participating ICU confirmed Short Period Incidence Study Severe Acute Respiratory Infection (SPRINT-SARI) study between February 2020 May 2024. Primary outcome: In-hospital mortality. Secondary outcomes: mortality; hospital lengths stay; supportive disease-specific therapies....
Diabetic ketoacidosis (DKA) is a hyperglycaemic emergency, and insulin administration highly protocolised with either variable- or fixed-rate intravenous infusions. There are limited data supporting superiority of one regimen over another; however, international guidelines recommend To characterise DKA management protocols used in Australian hospitals. An online survey endocrinologists intensive care physicians between May July 2024. The main outcome measure was the proportion respondents...
Sodium-glucose transporter-2 (SGLT2) inhibitors reduced the incidence of acute kidney injury in large cardiovascular outcome trials patients with chronic heart and failure. Acute is a common complication following cardiac surgery. We hypothesized that perioperative SGLT2 inhibition could reduce after surgery, measured biomarker neutrophil gelatinase-associated (NGAL). In this open-label phase IV, randomized, parallel-group, pilot study, adult undergoing elective surgery cardiopulmonary...
Patients with aneurysmal subarachnoid haemorrhage (aSAH) often receive multiple radiation based diagnostic studies. Cumulative exposure has been associated long term health consequences from both dose dependent deterministic harm and increased risk of developing adverse events in a non-dose dependant manner i.e. stochastic harm. The objective was to calculate cumulative the acute phase after aSAH. Single centre retrospective, observational study consecutive adult patients admitted ICU for...
Exogenous GLP-1 slows gastric emptying in health and diabetes leading to diminished glycemic excursions. Gastric is markedly accelerated by hypoglycemia. The primary objective was determine whether attenuates the acceleration of induced hypoglycemia.Ten healthy volunteers were studied on four separate days a randomized double-blind fashion. Blood glucose stabilized using glucose/insulin clamp at hypoglycemia (2.6 mmol/L two occasions [hypo]) or euglycemia (6.0 [eu]) between T = -15 45 min...
OBJECTIVE Acute hyperglycemia markedly slows gastric emptying. Exogenous GLP-1 also emptying, leading to diminished glycemic excursions. The primary objective was determine whether potentiates the slowing of emptying induced by administration. RESEARCH DESIGN AND METHODS Ten healthy participants were studied on 4 separate days. Blood glucose clamped at using an intravenous infusion 25% dextrose (∼12 mmol/L; hyper) 2 days, or maintained euglycemia (∼6 eu) between t = −15 and 240 min. During...