A5029121343- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes Management and Research
- Enhanced Recovery After Surgery
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Bariatric Surgery and Outcomes
- Intensive Care Unit Cognitive Disorders
- Acute Kidney Injury Research
- Anesthesia and Pain Management
- Cardiac Ischemia and Reperfusion
- Clinical practice guidelines implementation
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Respiratory Support and Mechanisms
- Gastric Cancer Management and Outcomes
- Cardiac and Coronary Surgery Techniques
- Dietary Effects on Health
- Cancer, Hypoxia, and Metabolism
- Medical Malpractice and Liability Issues
- Healthcare Systems and Technology
- Gastroesophageal reflux and treatments
- Restraint-Related Deaths
- Hip disorders and treatments
University of Amsterdam
2016-2025
The University of Melbourne
2024-2025
Amsterdam University Medical Centers
2018-2025
Florey Institute of Neuroscience and Mental Health
2024
Amphia Ziekenhuis
2019-2020
OLVG
2019
Amsterdam UMC Location University of Amsterdam
2016-2018
Barro Colorado Island
2016
Slotervaartziekenhuis
2016
Abstract Aims Most cardiac surgery patients, with or without diabetes, develop perioperative hyperglycaemia, for which intravenous insulin is the only therapeutic option. This labour‐intensive and carries a risk of hypoglycaemia. We hypothesized that preoperative administration glucagon‐like peptide‐1 receptor agonist liraglutide reduces number patients requiring glycaemic control during surgery. Materials methods In this randomized, blinded, placebo‐controlled, parallel‐group, balanced...
Abstract Aims/hypothesis During hyperglycaemia, some glucose bypasses glycolysis and is metabolised via the potentially neurotoxic polyol pathway, in which to sorbitol fructose. Increased concentrations have been demonstrated cerebrospinal fluid (CSF) of neurological patients with without diabetes mellitus. However, levels evident abnormalities not investigated so far. The aim this study was determine CSF major disease normal or elevated concentrations. Methods This observational cohort used...
Introduction Surgical trauma induces a metabolic stress response, resulting in reduced insulin sensitivity and hyperglycaemia. Postoperative resistance (IR) is associated with postoperative complications, extended preoperative fasting may further aggravate the response. Nutritional strategies, such as carbohydrate loading (CHL), have been successfully used to attenuate IR. Recent evidence suggests that time-restricted feeding (TRF), form of intermittent fasting, improves IR general...
Sodium-glucose transporter-2 (SGLT2) inhibitors reduced the incidence of acute kidney injury in large cardiovascular outcome trials patients with chronic heart and failure. Acute is a common complication following cardiac surgery. We hypothesized that perioperative SGLT2 inhibition could reduce after surgery, measured biomarker neutrophil gelatinase-associated (NGAL). In this open-label phase IV, randomized, parallel-group, pilot study, adult undergoing elective surgery cardiopulmonary...
Historically, metformin was withheld before surgery for fear of metformin‐associated lactic acidosis. Currently, however, this risk is deemed to be low and guidelines have moved towards the continuation metformin. We hypothesized that continuing peri‐operatively would lower postoperative serum glucose level without an effect on plasma lactate levels. performed a single‐blind multicentre randomized controlled trial in people with type 2 diabetes mellitus scheduled non‐cardiac continued (MF+...
Abstract Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common postoperative complication. Currently, no effective preventative strategies exist to mitigate CSA-AKI. Sodium-glucose transporter-2 (SGLT2) inhibitors reduced (AKI) incidence in large, randomized placebo-controlled, cardiovascular and outcome trials conducted patients with chronic disease. We hypothesized that perioperative SGLT2 inhibition could also reduce Methods In this open-label phase IV,...
Abstract Background People with type 2 diabetes mellitus treated sodium-glucose transporter-2 inhibitors (SGLT2i) have lower rates of acute kidney injury (AKI). Sepsis is responsible for the majority AKI in critically ill patients. This study investigated whether SGLT2i renoprotective an ovine model Gram-negative septic AKI. Methods Sixteen healthy merino ewes were surgically instrumented to enable measurement mean arterial pressure, cardiac output, renal blood flow, cortical and medullary...
Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after surgery. Methods: performed a pre-planned secondary analysis adult undergoing surgery included GLOBE trial. Patients were randomised to receive 0.6 mg on evening before and 1.2 induction anaesthesia, matching placebo. Perioperative...
Introduction Perioperative hyperglycaemia is common during cardiac surgery and associated with postoperative complications. Although intensive insulin therapy for glycaemic control can reduce complications, it carries the risk of hypoglycaemia. GLP-1 has potential to lower glucose without causing We hypothesise that preoperative liraglutide (a synthetic analogue) will number patients requiring achieve values<8 mmol l -1 in intraoperative period. Methods analysis designed a multi-centre...
Editor, Diabetes mellitus is a disease of endemic proportions, with an in-hospital prevalence up to 15%.1 Considering this we expected Dutch hospitals have protocol in place for the treatment diabetes peri-operative period. As hyperglycaemia and are associated postoperative complications,2 set out evaluate these protocols. We surveyed all hospitals, hypothesising that protocols would show considerable variability, reflecting diverse literature on topic. Between July 2016 January 2017,...
Delayed neurocognitive recovery (DNR; disorder up to 30 days postoperative) and postoperative disorders (POCD; 1-12 months occur frequently after surgery, with diabetes mellitus (DM) suggested contribute this. This was a single-center prospective cohort study. The main aim of this study investigate the role DM preoperative hemoglobin A1c (HbA1c) in development POCDs noncardiac surgery.Older adult patients ≥65 years age scheduled for elective surgery were recruited. Modified Telephone...
Most perioperative diabetes mellitus (DM) guidelines do not distinguish between patients with type 1 (DM1) and 2 (DM2). We hypothesised that similar treatment of DM1 DM2 leads to differences in their glucose control.We performed a retrospective cross-sectional study, all DM undergoing surgery May 2013 November 2015 Dutch university hospital. compared patients, treated according the same protocol. Our primary outcome was incidence hyperglycaemia (glucose ≥10 mmol/L). Secondary outcomes were...
A patient suffered massive subcutaneous emphysema and bilateral tension pneumothoraces after receiving supplemental oxygen through an airway exchange catheter (AEC). Complications of AEC placement include misplacement, direct injury to the larynx, bronchi or lung, barotrauma related supplementation, a loss airway. We review these complications discuss specific risks supplementing using AEC. suggest measures limit pressure from source warn against advancing too far into tracheobronchial tree.