A5053826661- Nutrition and Health in Aging
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Clinical Nutrition and Gastroenterology
- Anesthesia and Neurotoxicity Research
- Hip and Femur Fractures
- Colorectal Cancer Surgical Treatments
- Electrolyte and hormonal disorders
- Dietary Effects on Health
- Aldose Reductase and Taurine
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Vitamin C and Antioxidants Research
- Flavonoids in Medical Research
- Therapeutic Uses of Natural Elements
- Colorectal Cancer Treatments and Studies
- Diet and metabolism studies
- Bone health and osteoporosis research
- Birth, Development, and Health
- Prenatal Substance Exposure Effects
- Olfactory and Sensory Function Studies
- Frailty in Older Adults
- Colorectal and Anal Carcinomas
Amsterdam University Medical Centers
2022-2025
University of Amsterdam
2022-2025
Public Health Service of Amsterdam
2023
Amsterdam UMC Location University of Amsterdam
2011-2017
Medisch Centrum Alkmaar
2009-2015
Amsterdam UMC Location Vrije Universiteit Amsterdam
2008-2012
Spaarne Gasthuis
2011
University of Edinburgh
2011
GGZ inGeest
2011
Cambridge University Press
2010
Abstract Aim The Enhanced Recovery After Surgery ( ERAS ) programme is a multimodal approach to improve peri‐operative care in colon surgery. aim of this study was report on the adherence and outcomes first years after implementation. Method Data patients undergoing elective resections for malignancy 2006 until 2010 were compared with receiving conventional 2005. Retrospective analysis performed including length stay LOS ), protocol complications. predictive values items baseline...
Aging and neurodegenerative disease predispose to delirium are both associated with increased activity of the innate immune system resulting in an imbalance between pro- anti-inflammatory mediators brain. We examined whether hip fracture patients who develop postoperative have altered levels inflammatory cerebrospinal fluid (CSF) prior surgery. Patients were 75 years older admitted for surgical repair acute fracture. CSF samples collected preoperatively. In exploratory study, we measured 42...
The prognostic role of pericolic or perirectal isolated tumor deposits (ITDs) in node-negative colorectal cancer (CRC) patients is unclear. Rules to define ITDs as regional lymph node metastases changed subsequent editions the TNM staging without substantial evidence. Aim this study was investigate correlation between and disease recurrence stage II III CRC patients.The medical files 870 were reviewed. Number, size, shape, location pattern all examined relation involvement vascular...
Hip fracture surgery in elderly patients is associated with a poor postoperative outcome and high mortality. Malnutrition frequent problem may be mortality after hip surgery. The Mini Nutritional Assessment (MNA) valuable tool to identify malnourished those at risk for malnutrition.
Introduction Surgical trauma induces a metabolic stress response, resulting in reduced insulin sensitivity and hyperglycaemia. Postoperative resistance (IR) is associated with postoperative complications, extended preoperative fasting may further aggravate the response. Nutritional strategies, such as carbohydrate loading (CHL), have been successfully used to attenuate IR. Recent evidence suggests that time-restricted feeding (TRF), form of intermittent fasting, improves IR general...
Early postoperative oral feeding is safe and enhances recovery after surgery. To facilitate intake directly surgery in the Post Anaesthesia Care Unit (PACU) to enhance its associated benefits, knowledge on what patients would like eat and/or drink essential. Data taste preferences immediate period scarce, therefore this study investigated preference of PACU. A prospective observational adult scheduled for elective under general anaesthesia. Taste was our primary outcome, which we used...
OBJECTIVES: To examine the association between cerebrospinal fluid (CSF) β‐amyloid (Aβ1–42), tau, and hyperphosphorylated tau (Ptau) risk of delirium in older adults with hip fracture. DESIGN: Prospective cohort study. SETTING: University‐affiliated general hospital Alkmaar, Netherlands. PARTICIPANTS: Seventy‐six participants aged 75 admitted for surgical repair acute MEASUREMENTS: Presurgical baseline screening assessment included Informant Questionnaire on Cognitive Decline—short form...
ABSTRACT Background: Delirium is a risk factor for long-term cognitive impairment and dementia. Yet, the nature of these deficits unknown as extent to which persistence delirium symptoms presence depression at follow-up may account association between follow-up. We hypothesized that inattention, an important sign persistent and/or depression, feature profile three months after hospital discharge patients who experienced in-hosptial delirium. Methods: This was prospective cohort study....
To investigate the effects of an enteral supplement containing antioxidants on circulating levels and indicators oxidative stress after major gastrointestinal surgery.Twenty-one patients undergoing upper tract surgery were randomised in a single centre, open label study effect postoperative nutrition supplemented with antioxidants. The stress, such as F2-isoprostane, was studied.The antioxidant showed no adverse well tolerated. After decrease parameters observed. Only selenium glutamine...
Hip fracture patients represent a large part of the elderly surgical population and face severe postoperative morbidity excessive mortality compared to adult hip patients. Low antioxidant status taurine deficiency is common in elderly, may negatively affect outcome. We hypothesized that taurine, an antioxidant, could improve clinical outcome patient. A double blind randomized, placebo controlled, trial was conducted on Supplementation started after admission before surgery up sixth day....
Background: Nutrition studies in the intensive care unit (ICU) have shown that adequate enteral nutrition (EN) support has clinical benefits. However, course of amino acid concentrations plasma never been investigated patients admitted with shock receiving EN. We hypothesized concentrations, when deficit, increase during EN and persistent deficiency is associated poor outcome. Methods: In 33 septic or cardiogenic EN, were measured 5 days. Changes correlations outcome variables, regression...
Evidence accumulates that a family of plant compounds, known as flavonoids, can prevent or slow down the progression cardiovascular diseases, cancer, inflammatory and neurodegenerative diseases. Flavonoids are considered beneficial, this is often attributed to their powerful antioxidant properties. In role, certain types flavonoids be far more than two most common antioxidants, vitamin C E, at preventing cellular damage brought on by free radicals. Interestingly, exert those activities not...
Background . Features that may allow early identification of patients at risk prolonged delirium, and therefore poorer outcomes, are not well understood. The aim this study was to determine if preoperative delirium factors symptoms (at onset clinical symptomatology during the course delirium) associated with duration. Methods This conducted in prospectively identified cases incident delirium. We compared experiencing short duration (1 or 2 days) who had more (≥3 regard DRS-R-98 (Delirium...
Abstract Background : Insulin resistance after surgery hampers recovery. Oxidative stress is shown to be involved in the occurrence of postoperative insulin resistance. Preoperative carbohydrate‐rich oral nutrition supplements reduce but do not prevent The aim present study was investigate effect a carbohydrate‐, glutamine‐, and antioxidant‐enriched preoperative supplement on Methods A double‐blind randomized controlled pilot 18 patients with rectal cancer, who received either (S) or placebo...
Major surgery induces an immuno-inflammatory response accompanied by oxidative stress that may impair cellular function and delay recovery. The objective of the study was to investigate effect enteral supplement, containing glutamine antioxidants, on circulating levels markers after major gastrointestinal tract surgery. Patients ( n 21) undergoing were randomised in a single-centre, open-label study. effects determined day before days 1, 3, 5 7 increased IL-6, TNF receptor 55/60 (TNF-R55)...