Elena Williams
A5057693512- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Health, Environment, Cognitive Aging
- Cell Image Analysis Techniques
- Genetic factors in colorectal cancer
- Delphi Technique in Research
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Breast Cancer Treatment Studies
- EEG and Brain-Computer Interfaces
- RNA and protein synthesis mechanisms
- Bat Biology and Ecology Studies
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Gene expression and cancer classification
- Mosquito-borne diseases and control
- Lung Cancer Treatments and Mutations
- Rabies epidemiology and control
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Immune Cell Function and Interaction
Genomics England
2022-2025
University of Cambridge
2020-2024
MRC Laboratory of Molecular Biology
2023-2024
Medical Research Council
2023
Cancer Research UK Cambridge Center
2021-2022
IIT@MIT
2021
McGovern Institute for Brain Research
2021
Engineering Arts (United States)
2021
Allen Institute
2021
Howard Hughes Medical Institute
2021
Accurate measurement of clonal genotypes, mutational processes, and replication states from individual tumor-cell genomes will facilitate improved understanding tumor evolution. We have developed DLP+, a scalable single-cell whole-genome sequencing platform implemented using commodity instruments, image-based object recognition, open source computational methods. Using we generated resource 51,926 matched cell images diverse types including lines, xenografts, diagnostic samples with limited...
Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing mutational signatures, imprints of DNA damage and repair processes that have arisen in each patient's cancer. We performed signature analyses on 12,222 WGS tumor-normal matched pairs, from patients recruited via the UK National Health Service. contrasted our results to two independent datasets, International Cancer Genome Consortium (ICGC) Hartwig Foundation, involving 18,640 cancers total. Our add 40...
How cell-to-cell copy number alterations that underpin genomic instability
Abstract The execution of goal-oriented behaviours requires a spatially coherent alignment between sensory and motor maps. current model for sensorimotor transformation in the superior colliculus relies on topographic mapping static spatial receptive fields onto movement endpoints 1–6 . Here, to experimentally assess validity this canonical alignment, we dissected visuo-motor network performed vivo intracellular extracellular recordings across layers, restrained unrestrained conditions, both...
The heterogeneity of breast cancer plays a major role in drug response and resistance has been extensively characterized at the genomic level. Here, single-cell mass cytometry (BCMC) panel is optimized to identify cell phenotypes their oncogenic signalling states biobank patient-derived tumour xenograft (PDTX) models representing diversity human cancer. BCMC identifies 13 cellular (11 2 murine), associated with both subtypes specific features. Pre-treatment phenotypic composition determinant...
Abstract Background Whole-genome sequencing (WGS) of cancers is becoming an accepted component oncological care, and NHS England currently rolling out WGS for all children with cancer. This approach was piloted during the 100,000 genomes (100 K) project. Here we share experience East Genomic Medicine Centre (East-GMC), reporting feasibility clinical utility centralised individual locally. Methods Non-consecutive solid tumours were recruited into pilot 100 K project at our Centre. Variant...
Summary: The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment. See related article Stratton et al., p. 22...
<p>IMAXT Consortium Author List</p>
<div>Summary:<p>The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment.</p><p><a...
<p>IMAXT Consortium Author List</p>
Abstract Mapping the molecular identities and functions of cells within their spatial context is key to understanding complex interplay between tissue neighbourhoods. A wide range methods have recently enabled profiling cellular anatomical contexts, some offering single-cell resolution. These use different barcoding schemes encode either location or identity target molecules. However, all these technologies face a trade-off resolution, depth profiling, scalability. Here, we present B...