A5043923559- Chronic Kidney Disease and Diabetes
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Parathyroid Disorders and Treatments
- Cellular transport and secretion
- Renal cell carcinoma treatment
- Mosquito-borne diseases and control
- MRI in cancer diagnosis
- Pregnancy and preeclampsia studies
- Photoreceptor and optogenetics research
- Global Cancer Incidence and Screening
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Neuroscience and Neural Engineering
- CAR-T cell therapy research
- Cell Image Analysis Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Long-Term Effects of COVID-19
- Pancreatic and Hepatic Oncology Research
- Health, Environment, Cognitive Aging
- Renal Diseases and Glomerulopathies
- Bat Biology and Ecology Studies
- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
Cold Spring Harbor Laboratory
2021-2024
MRC Laboratory of Molecular Biology
2017-2023
University of Cambridge
2017-2023
Medical Research Council
2023
Addenbrooke's Hospital
2017
Racially minoritized and socioeconomically disadvantaged populations are currently underrepresented in clinical trials. Data-driven, quantitative analyses strategies required to help address this inequity.
Objective We assessed whether famotidine improved inflammation and symptomatic recovery in outpatients with mild to moderate COVID-19. Design Randomised, double-blind, placebo-controlled, fully remote, phase 2 clinical trial ( NCT04724720 ) enrolling unvaccinated adult confirmed COVID-19 between January 2021 April from two US centres. Patients self-administered 80 mg (n=28) or placebo (n=27) orally three times a day for 14 consecutive days. Endpoints were time (primary) rate of (secondary)...
Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions. Many patients exhibit elevated plasma CyC levels, particularly during glucocorticoid (GC) treatment. This study links GCs with CyC's systemic regulation by utilizing genome-wide association and structural equation modeling to determine production genetics in the UK Biobank. Both polygenic score (PGS) capturing predisposition were associated increased all-cause cancer-specific mortality. We found that...
Transsynaptic viral vectors provide means to gain genetic access neurons based on synaptic connectivity and are essential tools for the dissection of neural circuit function. Among them, retrograde monosynaptic ΔG-Rabies has been widely used in neuroscience research. A recently developed engineered version ΔG-Rabies, non-toxic self-inactivating (SiR) virus, allows long term manipulation circuits. However, high mutational rate rabies virus poses a risk that mutations targeting key regulatory...
Management of patients with cancer, specifically carboplatin dosing, requires accurate knowledge glomerular filtration rate (GFR). Direct measurement GFR is resource limited. Available models for estimated (eGFR) are optimized without cancer and either isotope dilution mass spectrometry (IDMS)- or non-IDMS-standardized creatinine measurements. We present an eGFR model compatible both methods.
Abstract Transsynaptic viral vectors provide means to gain genetic access neurons based on synaptic connectivity and are essential tools for the dissection of neural circuit function. Among them, retrograde monosynaptic ΔG-Rabies has been widely used in neuroscience research. A recently developed engineered version ΔG-Rabies, non-toxic self-inactivating (SiR) virus, represents first tool open-ended manipulation circuits. However, high mutational rate rabies virus poses a risk that mutations...
Summary Cystatin C (CyC) is a secreted cysteine protease inhibitor and its biological functions remain insufficiently characterized. Plasma CyC elevated in many patients, especially when receiving glucocorticoid (GC) treatment. Endogenous GCs are essential for life appropriately upregulated response to systemic stress. Here we empirically connect with regulation of CyC. We used genome-wide association structural equation modeling determine the genetics latent trait production UK Biobank....
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<p>Excel file containing Tables S7, S9-15, S18</p>
<p>CamGFR v2 App Screenshot</p>
<p>Supplemental Materials</p>
<p>Supplemental Materials</p>
<p>CamGFR v2 App Screenshot</p>
<p>Excel file containing Tables S7, S9-15, S18</p>
<div>AbstractPurpose:<p>Management of patients with cancer, specifically carboplatin dosing, requires accurate knowledge glomerular filtration rate (GFR). Direct measurement GFR is resource limited. Available models for estimated (eGFR) are optimized without cancer and either isotope dilution mass spectrometry (IDMS)- or non-IDMS–standardized creatinine measurements. We present an eGFR model compatible both methods.</p>Experimental Design:<p>GFR measurements,...
<div>AbstractPurpose:<p>Management of patients with cancer, specifically carboplatin dosing, requires accurate knowledge glomerular filtration rate (GFR). Direct measurement GFR is resource limited. Available models for estimated (eGFR) are optimized without cancer and either isotope dilution mass spectrometry (IDMS)- or non-IDMS–standardized creatinine measurements. We present an eGFR model compatible both methods.</p>Experimental Design:<p>GFR measurements,...
6524 Background: Racially minoritized and socioeconomically disadvantaged populations are underrepresented in cancer clinical trials. Data-driven, quantitative approaches required to address this inequity. Here, we systematically analyze the geographical distribution of self-identified racial socioeconomic demographics within commuting distance trial centers all hospitals U.S.-wide. Methods: We calculate living 30-, 60-, 120-minute one-way driving commute times from U.S. hospitals. Data...
Abstract The current under-representation of racial and ethnic minorities socio-economically disadvantaged participants in clinical trials represents an important problem, because it reduces generalizability trial results should urgently be addressed all diseases. Decentralized may improve engagement under-represented populations with long-standing health disparities relevant to patients pancreatic cancer who would benefit from at home participation. We completed a fully decentralized...