Sean Beatty
A5078802242- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- Health, Environment, Cognitive Aging
- RNA Interference and Gene Delivery
- BRCA gene mutations in cancer
- Delphi Technique in Research
- Evolution and Genetic Dynamics
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Salmonella and Campylobacter epidemiology
- Endoplasmic Reticulum Stress and Disease
- Health and Medical Research Impacts
- Innovations in Concrete and Construction Materials
- BIM and Construction Integration
- DNA Repair Mechanisms
- Architecture and Computational Design
- Bacterial Genetics and Biotechnology
- Iron Metabolism and Disorders
- Cell Image Analysis Techniques
- Hemoglobinopathies and Related Disorders
- Gene expression and cancer classification
- Bacteriophages and microbial interactions
University of British Columbia
2025
Terry Fox Research Institute
2022-2025
Canada's Michael Smith Genome Sciences Centre
2025
Turner Consulting Group (United States)
2020
McGill University
2012-2017
How cell-to-cell copy number alterations that underpin genomic instability
Abstract CX-5461 is a G-quadruplex stabilizer that exhibits synthetic lethality in homologous recombination-deficient models. In this multicentre phase I trial patients with solid tumors, 40 are treated across 10 dose levels (50–650 mg/m 2 ) to determine the recommended II (primary outcome), and evaluate safety, tolerability, pharmacokinetics (secondary outcomes). Defective recombination explored as predictive biomarker of response. generally well tolerated, 475 days 1, 8 15 every 4 weeks,...
The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium their role tumor initiation evolution remain poorly understood. Using single-cell DNA sequencing (49,238 cells) from BRCA1 BRCA2 carriers or wild-type individuals, we identified recurrent CNAs (for example, 1q-gain 7q, 10q, 16q 22q-loss) that are present a rare population cells across almost all samples (n = 28). In BRCA1/BRCA2 carriers, these occur before loss heterozygosity (LOH) alleles. These CNAs,...
ABSTRACT The central, mortality-associated hallmark of cancer is the process metastasis. It increasingly recognized that bacteria influence multiple facets progression, but extent to which tumor microenvironment-associated control metastasis in poorly understood. To identify tumor-associated and their role metastasis, we utilized established murine models non-metastatic metastatic breast tumors capable driving disease. We found several species Bacillus genus were unique tumors, cells...
Summary: The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment. See related article Stratton et al., p. 22...
<p>IMAXT Consortium Author List</p>
<div>Summary:<p>The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment.</p><p><a...
<p>IMAXT Consortium Author List</p>
Background: While hundreds of Fulbright awards have been given, little is known about the impact such engagement despite a goal increased research partnership and collaboration.Aim: The extent award was explored by examining referencing primary collaborative publications.Setting: Seven databases two alternative sources from 2013 to 2023 were reviewed.Methods: Co-citation analysis identified pairs referenced articles. Subsequently, bibliometric approach used quantitatively visually capture...
Retention of iron in tissues macrophages via upregulation hepcidin (HAMP) and downregulation the exporter ferroportin (FPN) is thought to participate establishment anemia inflammation after infection. However, an FPN has been proposed limit access intracellular pathogens. We therefore studied homeostasis particular regulation infection with Salmonella enterica serovar Typhimurium mice presenting tissue high (AcB61), basal (A/J wildtype mice), or low (Hamp knock out, Hamp-/-) levels. The...
Abstract Background The encoding of cell intrinsic drug resistance states in breast cancer reflects the contributions genomic and non-genomic variations requires accurate estimation clonal fitness from co-measurement transcriptomic data. Somatic copy number (CN) variation is dominant mutational mechanism leading to transcriptional notably contributes platinum chemotherapy states. Here, we deploy time series measurements triple negative (TNBC) single-cell transcriptomes, along with...
Digital fabrication has significant potential to support concrete formwork in the construction industry. While previous studies have been done on digital construction, few empirical investigations taken into account cost-effectiveness of fabrication, which is a crucial factor. Currently, percevied high initial cost equipment makes companies reluctant change their traditional approach. To address this knowledge gap, study aims determine financial benefits using technology fabrication....
Abstract Assessing tumour gene fitness in physiologically-relevant model systems is challenging due to biological features of vivo regeneration, including extreme variations single cell lineage progeny. Here we develop a reproducible, quantitative approach pooled genetic perturbation patient-derived xenografts (PDXs), by encoding output from transplanted CRISPR-transduced cells combination with Bayesian hierarchical model. We apply this 181 PDX transplants 21 breast cancer patients. show...
ABSTRACT Structural genome alterations are determinants of cancer ontogeny and therapeutic response. While bulk sequencing has enabled delineation structural variation (SV) mutational processes which generate patterns DNA damage, we have little understanding how these lead to cell-to-cell variations underlie selection rates accrual different genomic lesions. We analysed 309 high grade serous ovarian triple negative breast genomes determine their processes, selecting 22 from sequenced...
Abstract Cancer genomes exhibit extensive chromosomal copy number changes and structural variation, yet how allele specific alterations drive cancer genome evolution remains unclear. Here, through application of a new computational approach we report in 11,097 single cell whole from genetically engineered mammary epithelial cells 21,852 high grade serous ovarian triple negative breast cancers. Resolving profiles to individual alleles uncovered genomic background distributions gains, losses...
Abstract Cancer-associated mutations have been documented in normal tissues, but the prevalence and nature of somatic copy number alterations their role tumor initiation evolution is not well understood. Here, using single cell DNA sequencing, we describe landscape CNAs >42,000 breast epithelial cells from women with or high risk developing cancer. Accumulation individual one two a specific subset (e.g. 1q gain 16q, 22q, 7q, 10q loss) detectable almost all tissues and, those BRCA1 BRCA2...
Abstract Background The encoding of cell intrinsic resistance states in breast cancer reflects the contributions genomic and non-genomic variation. However, identifying potential each requires accurate measurement subtraction contribution clonal fitness from co-measurement transcriptional states. Somatic variation gene dosage, copy number variation, is dominant mutational mechanism contributing to has recently been shown contribute platinum chemotherapy Here we deploy time series...
Background: Survival following acute infection with Salmonella Typhimurium, a systemic modelling human typhoid fever, is dependent upon coordinated and genetically complex immune response. Methods: We have screened panel of recombinant congenic strains (RCS) derived from reciprocal double backcrosses between A/J C57BL/6J for their susceptibility to infection. mice carry non-functional allele at Slc11a1 (also known as Nramp1), major determinant the host response Results: Among RCS carrying...