Tristan Whitmarsh
A5012867488- Bone health and osteoporosis research
- Medical Image Segmentation Techniques
- Advanced X-ray and CT Imaging
- Single-cell and spatial transcriptomics
- Hip and Femur Fractures
- Medical Imaging Techniques and Applications
- Hip disorders and treatments
- Medical Imaging and Analysis
- Bone and Joint Diseases
- Cell Image Analysis Techniques
- Cancer Genomics and Diagnostics
- Body Composition Measurement Techniques
- Bone Metabolism and Diseases
- Dental Radiography and Imaging
- Health, Environment, Cognitive Aging
- Advanced Fluorescence Microscopy Techniques
- Scientific Computing and Data Management
- Orthopaedic implants and arthroplasty
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
- Delphi Technique in Research
- Central Venous Catheters and Hemodialysis
- Bayesian Methods and Mixture Models
- Ocular Diseases and Behçet’s Syndrome
- Cutaneous lymphoproliferative disorders research
University of Cambridge
2014-2025
Cancer Research UK
2025
Engineering Arts (United States)
2021
Nara Institute of Science and Technology
2019
Universitat Pompeu Fabra
2010-2013
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2010-2013
University of Sheffield
2013
Abstract The tumor microenvironment plays a crucial role in determining response to treatment. This involves series of interconnected changes the cellular landscape, spatial organization, and extracellular matrix composition. However, assessing these alterations simultaneously is challenging from perspective, due limitations current high-dimensional imaging techniques extent intratumoral heterogeneity over large lesion areas. In this study, we introduce proteomic workflow termed Hyperplexed...
The accurate diagnosis of osteoporosis has gained increasing importance due to the aging our society. Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is an established criterion in osteoporosis. This measure, however, limited its two-dimensionality. work presents a method reconstruct both 3D shape and BMD distribution proximal femur from single DXA image used clinical routine. A statistical model combined presented, together with for construction set...
Atlases and statistical models play important roles in the personalization simulation of cardiac physiology. For study heart, however, construction comprehensive atlases spatio-temporal is faced with a number challenges, particular need to handle large highly variable image datasets, multi-region nature presence complex as well small cardiovascular structures. In this paper, we present detailed atlas model human heart based on population 3D+time multi-slice computed tomography sequences,...
The heterogeneity of breast cancer plays a major role in drug response and resistance has been extensively characterized at the genomic level. Here, single-cell mass cytometry (BCMC) panel is optimized to identify cell phenotypes their oncogenic signalling states biobank patient-derived tumour xenograft (PDTX) models representing diversity human cancer. BCMC identifies 13 cellular (11 2 murine), associated with both subtypes specific features. Pre-treatment phenotypic composition determinant...
Abstract Background The risk of cutaneous squamous cell carcinoma (cSCC) is significantly increased in organ transplant recipients (OTRs). Clearance actinic keratoses (AKs) generally regarded as a surrogate biomarker for cSCC prevention. OTR-cSCC chemoprevention with topical AK treatments has not been investigated randomized controlled trials (RCTs), although there evidence that 5% 5-fluorouracil (5-FU) may be chemoprotective immunocompetent patients. Objectives To assess the feasibility,...
Summary: The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment. See related article Stratton et al., p. 22...
<p>IMAXT Consortium Author List</p>
<div>Summary:<p>The Imaging and Molecular Annotation of Xenografts Tumors Cancer Grand Challenges team was set up with the objective developing “next generation” pathology cancer research by using a combination single-cell spatial omics tools to produce 3D molecularly annotated maps tumors. Its activities overlapped, in some cases catalyzed, revolution biology that saw new technologies being deployed investigate roles tumor heterogeneity micro-environment.</p><p><a...
<p>IMAXT Consortium Author List</p>
Abstract Bone is in a continuous state of remodeling whereby old bone absorbed and new formed its place. During this process, formations reinforce the direction dominant stress trajectories through functional adaptation. In normal aging, balance between resorption formation can be shifted. How affects adaptation remains to investigated. Furthermore, how or whether continues change beyond age 85 not yet studied detail. study we examined age-related changes cortical trabecular age, assessed...
Area Bone Mineral Density (aBMD) measured by Dual-energy X-ray Absorptiometry (DXA) is an established criterion in the evaluation of hip fracture risk. The from these planar images, however, limited to 2D while it has been shown that proper 3D assessment both shape and (BMD) distribution improves risk estimation. In this work we present a method reconstruct bone BMD proximal femur single DXA image. A statistical model separate were automatically constructed set Quantitative Computed...
ABSTRACT Combining antiresorptive and anabolic drugs for osteoporosis may be a useful strategy to prevent hip fractures. Previous studies comparing the effects of alendronate (ALN) teriparatide (TPTD) alone, combined or sequentially using quantitative computed tomography (QCT) in postmenopausal women have not distinguished cortical bone mineral density (CBMD) from thickness (CTh) effects, nor assessed distribution extent more localized changes. In this study validated mapping technique was...
Romosozumab monoclonal antibody treatment works by binding sclerostin and causing rapid stimulation of bone formation while decreasing resorption. The location local magnitude vertebral accrual romosozumab how it compares to teriparatide remains be investigated. Here we analyzed the data from a study collecting lumbar computed tomography (CT) spine scans at enrollment 12 months post-treatment with (210 mg sc monthly, n = 17), open-label daily (20 μg sc, 19), or placebo (sc 20). For each 56...
Background Teriparatide (TPTD) is an anabolic agent indicated for the treatment of severely osteoporotic patients who are at high risk fragility fractures. The originally approved duration TPTD in several regions, including Europe, was 18 months. However, studies areal bone mineral density (aBMD) showed additional benefit when continued beyond months, and drug currently licenced 24 Improvements cortical structure proximal femur have already been shown given months using quantitative computed...
The diagnosis of osteoporosis and the prevention femur fractures is a major challenge for our society. However, performed in clinical routine from Dual Energy X-ray Absorptiometry (DXA) images limited. This paper proposes 3D reconstruction method both shape Bone Mineral Density (BMD) distribution proximal routinely used DXA images. accuracy that can be obtained single-view multi-view devices was assessed. evaluation, 20 bone specimens simulated images, highlighted mean 1.3mm BMD 4.4% image....
With the aim of producing a 3D representation tumors, imaging and molecular annotation xenografts tumors (IMAXT) uses large variety modalities in order to acquire tumor samples produce map every cell its host environment. volume data produced project, we developed automatic workflows analysis pipelines. We introduce research methodology where scientists connect cloud environment perform close are located, instead bringing their local computers. Here, present infrastructure, discuss unique...
ABSTRACT A set of increasingly powerful approaches are enabling spatially resolved measurements growing numbers molecular features in biological samples. While important insights can be derived from the two-dimensional data that many these technologies generate, it is clear extending into third and fourth dimensions will magnify their impact. Realizing datasets where thousands to millions cells annotated with tens hundreds parameters space require development new computational visualization...
Purpose: Dual‐energy x‐ray absorptiometry (DXA) is used in clinical routine to provide a two‐dimensional (2D) analysis of the bone mineral density (BMD). 3D reconstruction methods from 2D DXA images could improve BMD analysis. To find optimal configuration that should be routine, this paper relies on method compare accuracy can obtained one single‐view and multiview (two four projections). Methods: The uses statistical model nonrigid registration technique recover shape distribution proximal...
Computational atlases based on nonrigid registration have found much use in the medical imaging community. To avoid bias to any single element of training set, there are two main approaches: using a (random) subject serve as an initial reference and posteriorly removing bias, true groupwise with constraint zero average transformation for direct computation atlas. Major drawbacks possible selection outlier one side, initialization invalid instance other. In both cases is great potential...