F. J. Lopez
A5059319222- Genetic and phenotypic traits in livestock
- Agricultural and Food Production Studies
- Effects of Environmental Stressors on Livestock
- Reproductive Physiology in Livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Genomics and Diagnostics
- Meat and Animal Product Quality
- Milk Quality and Mastitis in Dairy Cows
- Animal Nutrition and Physiology
- Genomic variations and chromosomal abnormalities
- Livestock and Poultry Management
- Genetic factors in colorectal cancer
- Genetics and Plant Breeding
- Sustainable Agricultural Systems Analysis
- Natural Products and Biological Research
- Livestock Management and Performance Improvement
- Chromosomal and Genetic Variations
- Epigenetics and DNA Methylation
- Forensic and Genetic Research
- Metabolism and Genetic Disorders
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Animal Behavior and Welfare Studies
- Ruminant Nutrition and Digestive Physiology
- Latin American rural development
Universidad Nacional Autónoma de México
2015-2025
Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias
2015-2025
Genomics England
2020-2025
Universidad de Cuautitlán Izcalli
2016-2025
Universidad Autónoma de Nuevo León
2021-2023
Secretariat of Agriculture, Livestock, Rural Development, Fisheries and Food
2009-2023
Texas A&M University
2016
Autonomous University of Queretaro
1998
Significance The introduction of genomic selection in dairy cattle improvement programs 2008 was expected to increase rates genetic gain, particularly for traits with low heritabilities, such as fertility and longevity. Our analysis the US national database found that generation intervals have decreased dramatically over past 6 y, intensity lowly heritable has increased considerably. Genetic trends rapidly fertility, lifespan, udder health. These results clearly demonstrate positive impact...
Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing mutational signatures, imprints of DNA damage and repair processes that have arisen in each patient's cancer. We performed signature analyses on 12,222 WGS tumor-normal matched pairs, from patients recruited via the UK National Health Service. contrasted our results to two independent datasets, International Cancer Genome Consortium (ICGC) Hartwig Foundation, involving 18,640 cancers total. Our add 40...
Several strands of evidence question the dogma that human mitochondrial DNA (mtDNA) is inherited exclusively down maternal line, most recently in three families where several individuals harbored a 'heteroplasmic haplotype' consistent with biparental transmission. Here we report similar genetic signature 7 11,035 trios, allelic fractions 5-25%, implying inheritance mtDNA 0.06% offspring. However, analysing nuclear whole genome sequence, observe likely large rare or unique...
The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures how essential gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice the International Mouse Phenotyping Consortium essentiality carried out human cell lines. We propose cross-species classification across Full Spectrum Intolerance Loss-of-function (FUSIL)...
Abstract The value of genome-wide over targeted driver analyses for predicting clinical outcomes cancer patients is debated. Here, we report the whole-genome sequencing 485 chronic lymphocytic leukemia enrolled in trials as part United Kingdom’s 100,000 Genomes Project. We identify an extended catalog recurrent coding and noncoding genetic mutations that represents a source future studies provide most complete high-resolution map structural variants, copy number changes global genome...
Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer
Mastitis, the most common and expensive disease in dairy cows, implies significant losses industry worldwide. Many efforts have been made to improve genetic mastitis resistance populations, but low heritability of this trait process not as effective desired. The purpose study was identify genomic regions explaining variation somatic cell count using copy number variations (CNVs) markers Holstein population, genotyped with Illumina BovineHD BeadChip. We found 24 47 significantly associated...
Abstract Background Whole-genome sequencing (WGS) of cancers is becoming an accepted component oncological care, and NHS England currently rolling out WGS for all children with cancer. This approach was piloted during the 100,000 genomes (100 K) project. Here we share experience East Genomic Medicine Centre (East-GMC), reporting feasibility clinical utility centralised individual locally. Methods Non-consecutive solid tumours were recruited into pilot 100 K project at our Centre. Variant...
Copy number variations are genome polymorphism that influence phenotypic variation and an important source of genetic in populations. The aim this study was to investigate variability the Mexican Creole chicken population using CNVs. Hidden Markov Model PennCNV software detected a total 1924 CNVs 256 samples processed with Axiom® Genome-Wide Chicken Genotyping Array (Affymetrix). mapped comprised 1538 gains 386 losses, resulting at level 1216 CNV regions (CNVRs), which 959 gains, 226 losses...
Genomic and genetic variation among six Italian chicken native breeds (Livornese, Mericanel della Brianza, Milanino, Bionda Piemontese, Bianca di Saluzzo Siciliana) were studied using single nucleotide polymorphism (SNP) copy number variants (CNV) as markers. A total of 94 DNA samples genotyped with Axiom® Genome-Wide Chicken Genotyping Array (Affymetrix) used in the analyses. The results showed genomic variability occurring breeds. relationship animals was established a principal component...
The objective of this study was to evaluate the proportion genetic variance explained by single nucleotide polymorphism markers, individually or clustered in 1, 2, and 5 Mb windows, for milk yield, fat protein content, somatic cell score Mexican Holstein cattle. analysis included data from 640,746 lactation records 358,857 cows born between 1979 2019, distributed 353 herds 18 states Mexico. genotypic on 7,713 577 sires, with information 88,911 markers previously imputed filtered quality...
Modeling lactation curves with mathematical equations is useful to describe and predict the productivity of dairy cows. However, studies analyzing performance different models in small-scale systems are sparse. Therefore, objective this study was evaluate capacity five cows a system. Monthly milk weighins from 936 lactations were conducted 23 farms western Mexico. The Bayesian information criterion (BIC) mean square prediction error (MSPE) used assess fit observed data, root as percentage...
Abstract Background Findings from previous gastric cancer microbiome studies have been conflicting, potentially due to patient and/or tumor heterogeneity. The intratumoral and its relationship with clinicopathological variables not yet characterized in detail. We hypothesized that variation microbial abundance, alpha diversity, composition is related characteristics. Methods Metagenomic analysis of 529 GC samples was performed, including whole exome sequencing data Cancer Genome Atlas (TCGA)...
Genome sequencing was first offered clinically in the UK through 100,000 Genomes Project (100KGP). Analysis restricted to predefined gene panels associated with patient's phenotype. However, rely on clearly characterised phenotypes and risk missing diagnoses outside of panel(s) applied. We propose a complementary method rapidly identify pathogenic variants, including those missed by 100KGP methods.
Giardia is a protozoan that affects humans as well wide range of domestic species. It distributed worldwide, and the highest frequency seen in developing countries. Due to potential for cats be carriers this parasite subsequently transmit infection humans, it important know risk transmission. For reason, objective study was determine cat population city Santiago de Queretaro, Mexico, identify assemblages present role host plays public health, being first its type performed country. This...
At least half the population in industrialized countries suffers from obesity due to excessive accumulation of adipose tissue. Recently, rice (Oryza sativa) proteins have been considered valuable sources bioactive peptides with antiadipogenic potential. In this study, digestibility and bioaccessibility vitro a novel protein concentrate (NPC) were determined through INFOGEST protocols. Furthermore, presence prolamin glutelin was evaluated via SDS-PAGE, their potential bioactivity ligands...
Genetic variation enables both adaptive evolutionary changes and artificial selection. makeup of populations is the result a long-term process selection adaptation to specific environments ecosystems. The aim this study was characterize genetic variability México's chicken population reveal any underlying structure. A total 213 chickens were sampled in different rural production units located 25 states México. Genotypes obtained using Affymetrix Axiom® 600 K Chicken Genotyping Array....
Genomic selection has been proposed for the mitigation of methane (CH4) emissions by cattle because there is considerable variability in CH4 between individuals fed on same diet. The genome-wide association study (GWAS) represents an important tool detection candidate genes, haplotypes or single nucleotide polymorphisms (SNP) markers related to characteristics economic interest. present included information 280 cows three dairy production systems Mexico: 1) Dual Purpose (n = 100), 2)...
El objetivo fue conocer la estructura poblacional de los animales Holstein del sistema lechería familiar, identificar posibles orígenes material genético, el grado consanguinidad e huellas selección en genoma, que permitan vislumbrar las características se han mejorado a través años. estudio incluyó 270 genotipados con chip GGP-50K®. Después control calidad genotipos, incluyeron 43,548 SNP autosómicos. Para realizaron análisis mezclas y componentes principales (CP). genómica detectar...