A5051552019- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Influenza Virus Research Studies
- Intensive Care Unit Cognitive Disorders
- S100 Proteins and Annexins
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral Infections and Immunology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Chronic Kidney Disease and Diabetes
- Inflammasome and immune disorders
- Iron Metabolism and Disorders
- Liver Disease and Transplantation
- Vagus Nerve Stimulation Research
- Bone and Joint Diseases
- Vitamin C and Antioxidants Research
- Long-Term Effects of COVID-19
- Trauma and Emergency Care Studies
- Vitamin D Research Studies
- Rheumatoid Arthritis Research and Therapies
- Vector-Borne Animal Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Biomarkers in Disease Prognosis
University of Cambridge
2017-2024
Victor (Japan)
2023-2024
Project Directorate on Foot and Mouth Disease
2024
RELX Group (United States)
2024
Papworth Hospital NHS Foundation Trust
2023
Addenbrooke's Hospital
2020
Peterborough City Hospital
2011
Cambridge University Hospitals NHS Foundation Trust
2009
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms common, seemingly unrelated to severity. The true frequency underlying mechanisms of injury are unknown, but exaggerated host inflammatory responses appear be key driver We investigated the dynamics of, relationship between, serum markers brain [neurofilament light (NfL), glial fibrillary acidic protein (GFAP) total tau]...
INTRODUCTION: Systemic and neuroinflammatory responses mediate secondary injuries after traumatic brain injury (TBI), which lead to adverse outcomes. Identifying biomarkers of may enable early recognition patients at risk clinical decline delineate targets for therapeutic modulation. METHODS: The 18-center TRACK-TBI Study (years 2014-2018) enrolled who received head CT within 24-hours TBI. In 394 TBI patients, 100 orthopedic trauma controls (OCs), 67 healthy (HCs) with plasma (MesoScale...
Introduction International guidelines recommend systemic thrombolysis for high-risk acute pulmonary embolism (PE). Significant uncertainties remain regarding in non PE and the use of reduced-dose thrombolysis. To address this, United Kingdom (UK) respiratory trainees led a multicentre UK-wide study assessing current practice. Our primary aim was to evaluate UK practice against European Society Cardiology (ESC) recommendations (specifically utilise full-dose only PE). Secondary outcomes...
Influenza A virus (IAV) causes a wide range of extrarespiratory complications. However, the role host factors in these complications influenza infection remains to be defined.Here, we sought use transcriptional profiling, virology, histology, and echocardiograms investigate high-fat diet IAV-associated cardiac damage.Transcriptional profiling showed that, compared their low-fat counterparts (LF mice), mice fed (HF mice) had impairments inflammatory signaling lung heart after IAV infection....
BackgroundLow tidal volume ventilation (LTVV; < 8 mL/kg predicted body weight [PBW]) is a well-established standard of care associated with improved outcomes. This study used data collated in multicenter, electronic health record ICU databases from the United Kingdom and States to analyze use LTVV routine clinical practice.Research QuestionWhat factors are adherence North America?Study DesignThis was retrospective, multicenter across patients who were mechanically ventilated.MethodsFactors...
Objectives The steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy (25(OH)D) measurements hospitalised people COVID-19 influenza A survivors of critical illness test the hypotheses that insufficiency scales severity persists survivors. Design Cross-sectional study. Setting participants Plasma was obtained from 295 (International Severe Acute Respiratory emerging Infections...
Abstract Similar to other causes of acute respiratory distress syndrome, coronavirus disease 2019 (COVID‐19) is characterized by the aberrant expression vascular injury biomarkers. We present first report that circulating plasma bone morphogenetic proteins (BMPs), BMP9 and pBMP10, involved in protection, are reduced hospitalized patients with COVID‐19.
Background: The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation TBI have not improved patient outcomes. Methods: Serum plasma samples from two prospective, multi-centre observational studies of were used discover (Collaborative European NeuroTrauma Effectiveness Research [CENTER-TBI], Europe) validate (Transforming Clinical Knowledge Traumatic Brain Injury...
<b>Background:</b> Hyperferritinaemia in sepsis is associated with hyperinflammation, worse clinical outcomes, and may predict response to immunomodulation. The role of hyperferritinaemia ARDS from all-causes unknown. <b>Methods:</b> Baseline plasma ferritin was measured patients with ARDS two randomised controlled trials of simvastatin (HARP-2; discovery cohort, UK) neuromuscular blockade (ROSE; validation cohort, USA). Logistic regression model restricted cubic splines...
Abstract Respiratory viral pandemics result in large numbers of cases acute respiratory failure arising from a single etiology, thus reducing the heterogeneity precepting insult and allowing improved insight into variation host responses. In 2009-2011, an influenza pandemic occurred, with pH1N1 infecting millions people worldwide. Here, we have used novel bioinformatic methods to combine clinical, protein biomarker, genomic data patients influenza-associated identify three mechanistically...
A Sicilian man, aged 65, was admitted to hospital with melena. Ten years previously, he had been diagnosed limited cutaneous systemic sclerosis (CREST syndrome). His treatment included nifedipine patches for Raynaud's phenomenon and intermittent short courses of low-dose prednisolone. There were no risk factors viral hepatitis rarely consumed alcohol. Liver function tests normal apart from a mild elevation alanine aminotransferase (76 U/l). Endoscopy performed after resuscitation fluids...
<h3>Introduction</h3> The benefits of lung protective ventilation have been replicated in multiple trials.<sup>1,2</sup> However, we suspected that adherence to this standard care remained poor. Using the NIHR critical Health Informatics Collaborative (ccHIC) database, analysed data from 11 teaching hospital intensive units (22 524 patient episodes) investigate real-world clinical practice. <h3>Methods</h3> 1248 episodes, where was continued for ≥48 hours, with 232,600 hours concurrent...
<ns3:p><ns3:bold>Background:</ns3:bold> Mature human neutrophils are characterised by their multilobed nuclear morphology. Neutrophil hypersegmentation, a pathologic phenotype, has been described in the alveolar compartment of patients with acute respiratory distress syndrome and several other contexts. This study aimed to characterise transcriptional changes associated neutrophil hypersegmentation.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> A model hypersegmentation was established...