A5070848049- Asthma and respiratory diseases
- Respiratory viral infections research
- Influenza Virus Research Studies
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Pneumonia and Respiratory Infections
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Respiratory and Cough-Related Research
- Pleural and Pulmonary Diseases
- Pediatric Urology and Nephrology Studies
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Reconstructive Surgery and Microvascular Techniques
- Parasites and Host Interactions
- Pneumothorax, Barotrauma, Emphysema
- Transplantation: Methods and Outcomes
- Cystic Fibrosis Research Advances
- Ureteral procedures and complications
- Climate Change and Health Impacts
University of Cambridge
2019-2025
Cambridge University Hospitals NHS Foundation Trust
2021-2025
Nepal Medical College Teaching Hospital
2023
Addenbrooke's Hospital
2021-2022
Imperial College London
2016-2021
Papworth Hospital NHS Foundation Trust
2018-2021
St Mary's Hospital
2019
Lung Institute
2016-2018
St. Mary’s Hospital
2018
Abstract Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms underlying susceptibility are poorly understood. Here, we identify that obese individuals have deficient pulmonary antiviral immune responses in bronchoalveolar lavage cells not bronchial epithelial or peripheral blood dendritic cells. We show human airway metabolome perturbed with associated increases concentrations of adipokine leptin which correlated negatively magnitude ex vivo responses....
Abstract This study aims to develop a human lung immune challenge model using inhaled Resiquimod (R848), Toll-like receptor (TLR)7/8 agonist, investigate inflammatory mechanisms involved in the respiratory mucosa health and disease. approach seeks induce innate anti-viral responses lungs blood, with suitable dose of R848 that is clinically tolerable. The will include healthy volunteers individuals asthma. primary outcome change CXCL10, biomarker representative responses, at 24 hours...
We investigated the association between time of day and season testing on level bronchodilator responsiveness in a hospital-based population. found that per 1-hour increment working day, odds positive response decreased by 8%. A similar effect was seen when dichotomised into morning afternoon periods. When stratifying referral reason, impact only those referred for asthma/query asthma. also more common winter months compared with rest year.
Introduction International guidelines recommend systemic thrombolysis for high-risk acute pulmonary embolism (PE). Significant uncertainties remain regarding in non PE and the use of reduced-dose thrombolysis. To address this, United Kingdom (UK) respiratory trainees led a multicentre UK-wide study assessing current practice. Our primary aim was to evaluate UK practice against European Society Cardiology (ESC) recommendations (specifically utilise full-dose only PE). Secondary outcomes...
The methods of nasal absorption (NA) and bronchial (BA) use synthetic absorptive matrices (SAM) to absorb the mucosal lining fluid (MLF) human respiratory tract. NA is a non-invasive technique which absorbs from inferior turbinate, causes minimal discomfort. has yielded reproducible results with ability frequently repeat sampling upper airway. By comparison, alternative mucosa, such as nasopharyngeal aspiration (NPA) conventional swabbing, are more invasive may result in greater data...
Rationale: Suboptimal vaccine immunogenicity and antigenic mismatch, compounded by poor uptake, means that influenza remains a major global disease. T cells recognizing peptides derived from conserved viral proteins could enhance vaccine-induced cross-strain protection. Objectives: To investigate the kinetics, phenotypes, function of virus-specific CD8+ resident memory (Trm) in lower airway infer molecular pathways associated with their response to infection vivo. Methods: Healthy...
Background Patients with asthma are at risk of hospitalisation influenza, but the reasons for this predisposition unknown. Study setting A prospective observational study adults PCR-confirmed influenza in 11 UK hospitals, measuring nasal, nasopharyngeal and systemic immune mediators whole-blood gene expression. Results Of 133 admissions, 40 (30%) had previous asthma; these were more often female (70% versus 38.7%, OR 3.69, 95% CI 1.67–8.18; p=0.0012), required less mechanical ventilation...
There are limited effective prophylactic/early treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Viral entry requires spike protein binding to the angiotensin-converting enzyme-2 receptor and cleavage by transmembrane serine protease (TMPRSS2), a cell surface protease. Targeting of TMPRSS2 either androgen blockade or direct inhibition is in clinical trials early SARS-CoV-2
Background Prone positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence awake non-ventilated patients, with most studies being retrospective, lacking control populations and information on subjective tolerability. Methods We conducted prospective, single-centre study of prone COVID-19 non-COVID-19 pneumonia. The primary outcome was change peripheral oxygenation versus supine position. Secondary outcomes assessed effects...
<h3>Introduction</h3> To confirm resolution of air leak after intercostal chest drain (ICD) insertion for pneumothorax, physicians may clamp the ICD to mimic removal and/or use digital suction devices quantify leak. The CLAMP project aims assess whether these strategies impact rates recurrent repeat pleural procedures, or length stay. <h3>Methods</h3> Sites were recruited via INSPIRE, UK's respiratory trainee-led research network. Patients included admitted with primary secondary spontaneous...
Introduction: Renal cortical thickness is an important parameter for many renal pathologies. Ultrasonography has been efficient tool the measurement of different parameters. The objective this study was to determine in healthy adults without any impairments and correlate it with age, sex, height, weight, BMI side body.
 Materials Methods: A total 150 normal function were included study. detailed clinical history all patients taken. Basic investigations, ultrasonography examination...
<b>Background:</b> Asthmatic persons tend to suffer from severe influenza, but the reasons for enhanced severity are unknown. <b>Objectives:</b> To determine clinicopathological correlates of this susceptibility, we examined nasal and systemic immune responses in adults admitted hospital with influenza-like illnesses. <b>Methods:</b> We studied 210 patients illness at 11 hospitals UK across 2 winter seasons (2009/10 2010/11). Of these, 133 (63%) had confirmed influenza 40/133 (30%) were...
Abstract Background There are limited effective prophylactic treatments for SARS-CoV-2 infection, and early treatment options. Viral cell entry requires spike protein binding to the ACE2 receptor cleavage by TMPRSS2, a surface serine protease. Targeting of TMPRSS2 either androgen blockade or direct inhibition is already in clinical trials infection. Methods The likely initial cells ciliated upper airway. We therefore used differentiated primary human airway epithelial maintained at...
Ascariasis is the most prevalent helminthic infection to infest human beings caused by Ascaris lumbricoides. Rarely worm migrates through ampulla of Vater and may enter common bile duct. This a case report live lumbricodes in gallbladder, on USG. Med Phoenix. Vol. 3, Issue. 1, 2018, Page: 95-97
<b>Background:</b> Viruses play an important role in asthma exacerbations and are detected by Toll-like receptors (TLRs). Better characterization of mucosal innate immunity to viral triggers may help understand dysregulated host responses asthma. <b>Aims & Objectives:</b> A synthetic analogue single-stranded RNA (ssRNA) TLR7/8 agonist resiquimod (R848) was administered vivo study the effect allergy on nasal immune responses. <b>Methods:</b> Nasal spray with saline R848 healthy...