A5072069246- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Occupational exposure and asthma
- Pediatric health and respiratory diseases
- Health disparities and outcomes
- Hemodynamic Monitoring and Therapy
- Cardiovascular and exercise physiology
- Colorectal Cancer Screening and Detection
- Chronic Disease Management Strategies
- Obstructive Sleep Apnea Research
- Behavioral Health and Interventions
- Burn Injury Management and Outcomes
- Injury Epidemiology and Prevention
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Delphi Technique in Research
Imperial College London
2021-2025
Papworth Hospital
2025
University of Cambridge
2021-2025
Papworth Hospital NHS Foundation Trust
2025
Cambridge University Hospitals NHS Foundation Trust
2019-2025
Addenbrooke's Hospital
2021
Lung Institute
2021
Introduction Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with lower risk of developing cardiometabolic diseases. The aim this study was to assess the longitudinal association between spirometry measures and onset diseases across sites in low-income, middle-income countries. Methods population comprised 5916 individuals 15 countries participating Burden Obstructive Lung Disease baseline follow-up...
<title>Extract</title> The anaerobic threshold (AT) measured during a cardiopulmonary exercise test (CPET) is often considered as percentage of the peak VO<sub>2</sub> (VO<sub>2</sub>atAT/PeakVO<sub>2</sub>), with ratio less than 40% indicative disease. evidence for this based on findings Hansen <italic>et al</italic>. [1], that in population so called healthy ex-shipyard workers, no participants had VO<sub>2</sub>atAT/PeakVO<sub>2</sub> below 40%. It now widely accepted AT should be...
Background Measurement of total lung capacity (TLC) requires large and expensive equipment. We aimed to investigate whether spirometric restriction low alveolar volume measured by single breath gas transfer (VA) can be used identify those with a TLC. Methods retrospectively analysed data from adults referred Cambridge University Hospitals between January 2016 December 2023. investigated the utility (FVC <LLN FEV 1 /FVC ≥LLN) reduced VA (<LLN), discriminate TLC plethysmography (TLC...
We investigated the association between time of day and season testing on level bronchodilator responsiveness in a hospital-based population. found that per 1-hour increment working day, odds positive response decreased by 8%. A similar effect was seen when dichotomised into morning afternoon periods. When stratifying referral reason, impact only those referred for asthma/query asthma. also more common winter months compared with rest year.
Key Features• The Burden of Obstructive Lung Disease (BOLD) study was established to assess the prevalence chronic airflow obstruction, a key characteristic obstructive pulmonary disease, and its risk factors in adults (40 years) from general populations across world.• baseline conducted between 2003 2016, 41 sites Africa, Asia, Europe, North America, Caribbean Oceania, collected high-quality pre-and post-bronchodilator spirometry 28 828 participants.• follow-up 2019 2021, 18 Europe...
Background Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways associated with later in life. Methods used longitudinal data from 3957 participants the multinational Burden Obstructive Lung Disease study. defined using prebronchodilator mean forced expiratory flow rate between 25% and 75% vital capacity (FVC) (FEF 25–75 ) if result was less than lower limit normal (<LLN) presence volume 1 s to FVC...
Background Small airways obstruction (SAO) has been associated with occupational exposures. Whether exposure to harmful agents impacts the survival of people SAO is unknown. Our aim was estimate mortality risk exposures among SAO. Methods We used data from UK Biobank participants SAO, defined as a ratio forced expiratory volume in three seconds six (FEV 3 /FEV 6 ) below lower limit normal. assigned lifetime available histories using ALOHA+ Job Exposure Matrix. Mortality were provided by...
Small airways obstruction (SAO) is a key feature of both COPD and asthma, which have been associated with workplace exposures. Whether SAO, may occur early in the development obstructive lung disease without symptoms, also associates occupational exposures unknown.Using UK Biobank data, we derived measurements SAO from 65 145 participants high-quality spirometry lifetime histories. The ALOHA+ Job Exposure Matrix was used to assign each participant. association between evaluated using...
Chronic airflow obstruction is key for COPD diagnosis, but strategies its early detection are limited. We aimed to define the optimal z-score thresholds spirometry parameters discriminate chronic incidence. The Burden of Obstructive Lung Disease study a multinational cohort study. Information on respiratory symptoms was collected and pre- post-bronchodilator performed at baseline. 18 sites were followed-up with repeat measurements after median 8.4 years. converted lung function into z-scores...
In recent years, there has been increasing interest in the use of spirometry for assessment small airways obstruction (SAO) driven by idea that these changes occur prior to development established obstructive lung disease. Maximal mid-expiratory and distal flow rates have widely used despite a lack agreement regarding parameter selection or definition an abnormal result. We aim provide evidence from population-based studies, describing different parameters, definitions normal range resulting...
<h3>Background</h3> Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory condition, characterised by chronic airflow obstruction (CAO) and cause of significant morbidity mortality. Early identification individuals at risk developing CAO essential for timely interventions improved outcomes. The aim this study was to identify the optimal thresholds FEV<sub>1</sub>/FVC FEF<sub>25–75</sub> discriminate assess its COPD based on new thresholds. <h3>Methods</h3> We used data from...
Spirometry is used to determine what "unusual" lung function compared with "usual" for healthy non-smokers. This study aimed investigate regional variation in the forced vital capacity (FVC) and expiratory volume one second FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of multinational Burden Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, never smoked reported no respiratory symptoms or diagnoses. To...
<b>Background:</b> Isolated small airways obstruction is common in general populations. We aimed to investigate whether it associated with impaired cardiorespiratory fitness. <b>Methods:</b> analysed data from 222 patients referred for cardiopulmonary exercise test (CPET) and spirometry at Cambridge University Hospitals NHS foundation trust. investigated the association between isolated obstruction, defined as mean forced expiratory flow rate 25% 75% of vital capacity (FEF<sub>25–75</sub>)...
<b>Background:</b> Chronic respiratory diseases (asthma, COPD) are commonly associated with obstruction of the small airways (SAO), which has been occupational exposures. However, survival people SAO exposed to harmful agents not described. Our aim was assess mortality risk related exposures among SAO. <b>Methods:</b> We used data from UK Biobank participants and information on lifetime exposures, assigned individually using ALOHA+ Job Exposure Matrix. Mortality were provided by National...