A5021081775- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- Respiratory viral infections research
- Diabetes and associated disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Clostridium difficile and Clostridium perfringens research
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Pancreatitis Pathology and Treatment
- COVID-19 Impact on Reproduction
- Platelet Disorders and Treatments
- Biosensors and Analytical Detection
- Diabetes Management and Research
- Bacterial Identification and Susceptibility Testing
- Chronic Disease Management Strategies
- Phagocytosis and Immune Regulation
- Autoimmune Neurological Disorders and Treatments
Vienna General Hospital
2021-2022
Kaiser-Franz-Josef-Spital
2019-2022
Universitätszahnklinik Wien
2021-2022
Medical University of Vienna
2014-2021
Royal Children's Hospital
2021
Murdoch Children's Research Institute
2021
The University of Melbourne
2021
Austrian Competence Centre of Food Safety
2021
Klinik Hietzing
2021
Superspreading events shaped the coronavirus disease 2019 (COVID-19) pandemic, and their rapid identification containment are essential for control. Here, we provide a national-scale analysis of severe acute respiratory syndrome 2 (SARS-CoV-2) superspreading during first wave infections in Austria, country that played major role initial virus transmissions Europe. Capitalizing on Austria's well-developed epidemiological surveillance system, identified SARS-CoV-2 clusters performed deep...
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations MHC-I-restricted epitopes after deep sequencing of 747 isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding a cell-free vitro assay. Reduced mutant was associated with decreased proliferation, IFN-γ production cytotoxic activity cells isolated from HLA-matched patients. Single RNA ex vivo expanded, tetramer-sorted patients further...
To assess predictors of in-hospital mortality in people with prediabetes and diabetes hospitalized for COVID-19 infection to develop a risk score identifying those at the greatest fatal outcome.A combined prospective retrospective, multicentre, cohort study was conducted 10 sites Austria 247 or newly diagnosed who were COVID-19. The primary outcome predictor variables upon admission included clinical data, co-morbidities laboratory data. Logistic regression analyses performed identify...
Abstract We comparatively assessed sensitivities and specificities of 4 commercial enzyme-linked immunosorbent assays (ELISAs) 2 rapid tests in 77 patients with polymerase chain reaction–confirmed severe acute respiratory syndrome coronavirus infection, grouped by interval since symptom onset. Although test were low (<40%) within the first 5 days after disease onset, immunoglobulin (Ig) M, IgA, total antibody ELISAs increased sensitivity to >80% between 6 10 The evaluated...
Since the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several reports indicated neurological involvement in COVID-19 disease. Muscle has also been reported as evidenced by creatine kinase (CK) elevations and myalgia.Creatine kinase, markers inflammation, pre-existing diseases statin use were extracted from records Austrian hospitalised patients. Disease severity was classified case intensive care unit (ICU) admission or mortality. patients additionally...
In this study, we comprehensively analyzed multispecific antibody kinetics of different immunoglobulins in hospitalized patients with acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Three hundred fifty-four blood samples longitudinally obtained from 81 IgG-seroconverting progressed disease 2019 (CoVID-19) were quantified for spike 1 (S1), S2, and nucleocapsid protein (NCP)-specific IgM, IgA, IgG, total Ig antibodies using a microarray, 11 enzyme-linked immunosorbent...
Anticoagulation was associated with improved survival of hospitalized coronavirus disease 2019 (COVID-19) patients in large-scale studies. Yet, the development COVID-19-associated coagulopathy (CAC) and mechanism responsible for anticoagulated COVID-19 remain largely elusive. This investigation aimed to explore effects anticoagulation low-molecular-weight heparin (LMWH) particular on patient outcome, CAC development, thromboinflammation, cell death, viral persistence.Data 586 from three...
Thromboembolic complications are frequently observed in Coronavirus disease 2019 (COVID-19). While COVID-19 is linked to platelet dysregulation, the association between outcome and function less clear. We prospectively monitored activation reactivity 97 patients during first week of hospitalization determined plasma markers degranulation inflammation. Adverse was associated with increased basal diminished responses, which aggravated over time. Especially GPIIb/IIIa responses were abrogated,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a high mortality. To date no trial comparing hydroxychloroquine (HCQ) and lopinavir/ritonavir (LPV/RTV) has been performed.
Influenza A virus (IAV) causes a wide range of extrarespiratory complications. However, the role host factors in these complications influenza infection remains to be defined.Here, we sought use transcriptional profiling, virology, histology, and echocardiograms investigate high-fat diet IAV-associated cardiac damage.Transcriptional profiling showed that, compared their low-fat counterparts (LF mice), mice fed (HF mice) had impairments inflammatory signaling lung heart after IAV infection....
Background: The fatal consequences of an infection with severe acute respiratory syndrome coronavirus 2 are not only caused by pneumonia, but also thrombosis. Platelets important regulators thrombosis, their involvement in the pathogenesis COVID-19 is largely unknown. aim this study was to determine functional and biochemical profile patients dependence mortality within 5-days after hospitalization. Methods: COVID-19-related platelet phenotype examined analyzing basal activation state via...
A high rate of bacterial and fungal superinfections was reported in critically ill patients with COVID-19. However, diagnosis can be challenging. The aim this study is to evaluate the sensitivity clinical utility point-of-care method T2 magnetic resonance (T2MR) gold standard: blood culture. T2MR potentially detect five different Candida species six common bacteria (so-called "ESKAPE" pathogens including Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinet`obacter baumanii,...
Coronavirus disease 2019 (COVID-19) induces a hypercoagulatory state that frequently leads to thromboembolic complications. Whereas anticoagulation is associated with reduced mortality, the role of antiplatelet therapy in COVID-19 less clear. We retrospectively analyzed effect and 578 hospitalized patients prospectively monitored 110 for circulating microthrombi plasma markers coagulation first week admission. Moreover, we determined platelet shape change also thrombi postmortem lung...
Background: To date, no oral antiviral drug has proven to be beneficial in hospitalized patients with COVID-19. Methods: In this randomized, controlled, open-label, platform trial, we randomly assigned ≥18 years COVID-19 pneumonia receive either camostat mesylate (CM) (considered standard-of-care) or lopinavir/ritonavir (LPV/RTV). The primary endpoint was time sustained clinical improvement (≥48 h) of at least one point on the 7-category WHO scale. Secondary endpoints included length stay...
We report the successful management of a patient with severe respiratory failure due to COVID-19 admitted an intensive care unit complicated by secondary catheter-related infection Candida glabrata. are discussing some clinical challenges and pitfalls in molecular diagnosis SARS-CoV-2, including fact that positive PCR result may not always reflect infectiousness.
The COVID-19 pandemic drastically highlighted the vulnerability of elderly population towards viral and other infectious threats, illustrating that aging is accompanied by dysregulated immune responses currently summarized in terms like inflammaging immunoparalysis. To gain a better understanding on underlying mechanisms age-associated risk adverse outcome individuals experiencing SARS-CoV-2 infection, we analyzed impact age circulating monocyte phenotypes, activation markers inflammatory...
Abstract Superspreading events shape the COVID-19 pandemic. Here we provide a national-scale analysis of SARS-CoV-2 outbreaks in Austria, country that played major role for virus transmission across Europe and beyond. Capitalizing on national epidemiological surveillance system, performed deep whole-genome sequencing isolates from 576 samples to cover Austrian clusters. Our data chart map early viral spreading Europe, including path low-frequency mutations fixation. Detailed surveys enabled...
COVID-19 is regularly compared to influenza. Mortality and case-fatality rates vary widely depending on incidence of the testing policy in affected countries. To date, data comparing hospitalized patients with influenza scarce. Data from were infected A (InfA) B (InfB) virus during 2017/18 2018/19 seasons. All ≥ 18 years old, had PCR-confirmed infection needed hospital treatment. Demographic data, medical history, length-of-stay (LOS), complications including in-hospital mortality analyzed....
Objective To develop and validate a prognostic model for in-hospital mortality after four days based on age, fever at admission five haematological parameters routinely measured in hospitalized Covid-19 patients during the first admission. Methods Haematological 4 were subjected to linear mixed obtain patient-specific intercepts slopes each parameter. A prediction was built using logistic regression with variable selection shrinkage factor estimation supported by bootstrapping. Model...
Abstract CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control, though direct evidence lacking so far. Here, we identified non-synonymous mutations MHC-I restricted epitopes after deep sequencing of 747 SARS-CoV- 2 isolates. Mutant peptides exhibited diminished or abrogated binding, which was associated with a loss recognition functional responses by cells isolated from HLA-matched patients. Our findings highlight the capacity subvert surveillance...