A5043190657- Neuroscience and Neuropharmacology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Innovations in Medical Education
- Adipose Tissue and Metabolism
- Apelin-related biomedical research
- Cardiac Ischemia and Reperfusion
- Pharmacology and Obesity Treatment
- Gastroesophageal reflux and treatments
- Cholinesterase and Neurodegenerative Diseases
- Esophageal and GI Pathology
- SARS-CoV-2 and COVID-19 Research
- Regulation of Appetite and Obesity
- Long-Term Effects of COVID-19
- Hormonal and reproductive studies
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Reasoning and Diagnostic Skills
- Patient Safety and Medication Errors
- Helicobacter pylori-related gastroenterology studies
- Mormonism, Religion, and History
- Intensive Care Unit Cognitive Disorders
- Neuropeptides and Animal Physiology
- Salmonella and Campylobacter epidemiology
University of New Mexico
2024
Imperial College London
1980-2024
Beth Israel Deaconess Medical Center
2004-2023
Wythenshawe Hospital
2023
University of Maryland, Baltimore
2023
Emory University
2023
Regional Health
2020-2022
Newcastle University
2011-2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2022
University of Liverpool
2021-2022
Cases of human monkeypox are rarely seen outside west and central Africa. There few data regarding viral kinetics or the duration shedding no licensed treatments. Two oral drugs, brincidofovir tecovirimat, have been approved for treatment smallpox demonstrated efficacy against in animals. Our aim was to describe longitudinal clinical course a high-income setting, coupled with dynamics, any adverse events related novel antiviral therapies.
It has been postulated that the etiology of complications diabetes involves oxidative stress, perhaps as a result hyperglycemia. Consistent with this hypothesis, it shown glucose, under physiological conditions, produces oxidants possess reactivity similar to hydroxyl free radical. These hydroxylate benzoic acid, fragment protein, and induce peroxidation in phosphatidylcholine liposomes low-density lipoprotein (LDL) when LDL is incubated hyperglycemic levels glucose vitro. reactions are...
Abstract The purpose of the present investigation was to examine effect SRP on clinical and microbiological parameters in 57 subjects with adult periodontitis (mean age 47± 11 years). Subjects were monitored clinically micro‐biologically prior 3, 6 9 months after full‐mouth under local anaesthesia. Clinical assessments plaque, redness, suppuration, BOP, pocket depth attachment level made at sites per tooth. means duplicate measurements taken each visit used assess change between visits. data...
Abstract: Markers of serotonin synapses in entire temporal lobe and frontal neocortex were examined for changes Alzheimer's disease by use both neurosurgical autopsy samples. Uptake [ 3 H]sero‐tonin, binding H]imipramine, content indola‐mines all significantly reduced, indicating that nerve terminals are affected. Binding H]serotonin was also whereas H]qui‐nuclidinyl benzilate, H]muscimol, H]dihydroal‐prenolol unaltered. When the samples subdivided according to age, reduction a feature only...
Abstract: Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia. For those whom Alzheimer's disease was histologically confirmed, [ 14 C]acetylcholine synthesis, choline acetyltransferase activity and uptake all found to be markedly reduced (at least 40%) below mean control values. The changes occurred both the frontal temporal lobes for synthesis decrease similar under conditions high low neuronal (as assessed by...
Patients with gastroesophageal reflux disease who have a partial response to proton-pump inhibitors often seek alternative therapy. We evaluated the safety and effectiveness of new magnetic device augment lower esophageal sphincter.We prospectively assessed 100 patients before after sphincter augmentation. The study did not include concurrent control group. primary outcome measure was normalization acid exposure or 50% greater reduction in at 1 year. Secondary outcomes were improvement...
Abstract Background/aims: Previously, we reported that SRP resulted in a decrease mean pocket depth and attachment level reduced prevalence levels of Bacteroides forsythus , Porphyromonas gingivalis Treponema denticola at 3 6 months post‐SRP 57 subjects with adult periodontitis. 32 the were monitored 9 12 months. Thus, purpose present investigation was to evaluate microbial clinical effects (mean age 48±11) over 12‐month period. Method: Clinical assessments plaque, gingival redness,...
Visfatin is an adipocytokine capable of mimicking the glucose-lowering effects insulin and activating pro-survival kinases phosphatidylinositol-3-OH kinase (PI3K)-protein B (Akt) mitogen-activated protein 1 2 (MEK1/2)-extracellular signal-regulated (Erk 1/2). Experimental studies have demonstrated that activation these confers cardioprotection through inhibition mitochondrial permeability transition pore (mPTP). Whether visfatin exerting direct cardioprotective mechanisms unknown subject...
Abstract: Atrophy with ageing of human whole brain, entire temporal lobe, and caudate nucleus was assessed in autopsy specimens, by biochemical techniques. Only the showed changes. Markers for several neurotransmitter systems were also examined changes age. In neocortex lobe small decreases detected markers cholinergic nerve terminals, whereas a large decrease (79%) occurred nucleus. Findings similar striatum from 3–33‐month‐old rats. No change binding [ 3 H]quinuclidinyl benzilate samples....
Background and AimsGERD patients frequently complain of regurgitation gastric contents. Medical therapy with proton-pump inhibitors (PPIs) is ineffective in alleviating symptoms, because PPIs do nothing to restore a weak lower esophageal sphincter. Our aim was compare effectiveness increased PPI dosing laparoscopic magnetic sphincter augmentation (MSA) moderate-to-severe despite once-daily therapy.MethodsOne hundred fifty-two GERD, aged ≥21 years 8 weeks therapy, were prospectively enrolled...
To describe the neuropathological findings in two cases of fatal Coronavirus Disease 2019 (COVID-19) with neurological decline.Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection was confirmed both patients by reverse transcription polymerase chain reaction (RT-PCR) from nasopharyngeal swabs antemortem. Coronial autopsies were performed on and histological sampling brain undertaken a variety histochemical immunohistochemical stains. RNAscope® situ hybridization (ISH) using...
Protection against ischaemia-reperfusion (I/R) injury involves PI3K-Akt and p44/42 MAPK activation. Leptin which regulates appetite energy balance also promotes myocyte proliferation via We, therefore, hypothesized that leptin may exhibit cardioprotective activity.The influence of on I/R was examined in perfused hearts from C57Bl/6 J mice underwent 35 min global ischaemia reperfusion, infarct size being assessed by triphenyltetrazolium chloride staining. The concomitant activation...
Abstract: The neurochemical effects of the tremorgenic mycotoxins Verruculogen and Penitrem A, which produce a neurotoxic syndrome characterised by sustained tremors, were studied using sheep rat synaptosomes. toxins administered in vivo , either chronic feeding (sheep) or intraperitoneal injection 45 min prior to killing (rat) synaptosomes subsequently prepared from cerebrocortical spinal cord/medullary regions corpus striatum sheep. A (400 mg mycelium/kg) increased spontaneous release...
Leptin-induced protection against myocardial ischemia-reperfusion (I/R) injury involves the activation of reperfusion salvage kinase pathway, incorporating phosphatidylinositol 3-kinase-Akt/protein B and p44/42 MAPK, inhibition mitochondrial permeability transition pore (MPTP). Recently published data indicate that JAK/STAT signaling which mediates metabolic actions leptin, also plays a pivotal role in cardioprotection. Consequently, present study we considered possibility linked to MPTP may...
This paper systematically reviews previous studies of trust from social, economic and technological perspectives develops a holistic framework for trust, which can be used to analyse the establishment maintenance in online transactions, identify mechanisms that increase trust. Trust plays crucial role formation dependent relationships represented by treatment is necessary because gap exists between developments information systems our understanding their social implications, impact on...
HeLa cells contain beta-adrenergic receptors that are characterized by specific binding of I[3H]dihydroalprenolol, increased 3':5'-cyclic AMP production in intact after incubation with l-isoproterenol, and adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity the presence l-isoproterenol. After were cultured butyrate, number receptors, cyclic cells, activation l-isoproterenol severalfold over those untreated cells. The increase involved induction synthesis new receptor...