A5085757620- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- Ocular Oncology and Treatments
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Childhood Cancer Survivors' Quality of Life
- Brain Metastases and Treatment
- Nonmelanoma Skin Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Cancer therapeutics and mechanisms
- Gestational Trophoblastic Disease Studies
- Cancer-related Molecular Pathways
- CNS Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Mental Health and Patient Involvement
- Cancer Genomics and Diagnostics
- Vasculitis and related conditions
- Ultrasound in Clinical Applications
- Eosinophilic Disorders and Syndromes
- Genetic and Kidney Cyst Diseases
Hospital for Sick Children
2016-2025
SickKids Foundation
2015-2024
University of Toronto
2015-2024
Weill Cornell Medical College in Qatar
2024
Almaarefa University
2024
Alfaisal University
2024
Palmetto Hematology Oncology
2018-2023
Betsi Cadwaladr University Health Board
2021
National Health Service Wales
2021
New York Proton Center
2020
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Purpose To risk stratify malignant extracranial pediatric germ cell tumors (GCTs). Patients and Methods Data from seven GCT trials conducted by the Children's Oncology Group (United States) or Cancer Leukemia Kingdom) between 1985 2009 were merged to create a data set of patients with stage II IV disease treated platinum-based therapy. A parametric cure model was used evaluate prognostic importance age, tumor site, stage, histology, markers, treatment regimen estimate percentage who achieved...
BACKGROUND There is a debate regarding the management of ovarian immature teratomas (ITs). In adult women, postoperative chemotherapy standard except for stage I, grade 1 disease, whereas surgery alone in pediatric patients. To determine role chemotherapy, pooled analysis and clinical trials was conducted. METHODS Data from 7 2 were merged Malignant Germ Cell International Collaborative data set. Four included patients with newly diagnosed pure ITs selected (Pediatric Oncology...
Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In contrast, pre-pubertal I) limited to (benign) teratoma (malignant) yolk sac tumor (YST). Epidemiologic molecular data have shown pre- post-pubertal arise by distinct mechanisms. Dedicated studies genomic landscape type I II GCT children lacking. Here...
ABSTRACT Background Cisplatin, etoposide, and bleomycin (PEb) have been the standard of care for patients with germ cell tumors (GCT). In 1990s, an intergroup trial (POG9049/CCG8882) randomized high‐risk GCT, as defined by 1990 criteria, to high‐dose (HDPEb) versus standard‐dose PEb. HDPEb resulted in improved event‐free survival (EFS), but no difference overall (OS), thus PEb has remained care. Subsequently, Malignant Germ Cell International Consortium (MaGIC) updated risk stratification...
Abstract Background Ganglioneuromas (GNs) usually demonstrate favorable histological and clinical features. Surgery is often performed due to symptoms and/or theoretical concerns that GN may transform into neuroblastoma (NB); however, several studies have identified significant GN‐surgical morbidities. Objectives We compared the natural history, biological features of ganglioneuroblastoma‐intermixed (GNB‐I) managed by surgery or observation inform management surveillance. Procedures This...
Abstract The reproductive, endocrine, and growth effects of developmental lead exposure were assessed using a rat model in which 0.6% acetate (w/v) was administered the drinking water ad libitum during different periods to determine if actions result direct continuous metal ion or secondary disrupted neonatal "endocrine imprinting." Sprague Dawley rats exposed lead: (1) from gestational d 5 through birth; (2) pregnancy lactation; (3) lactation only; (4) birth adulthood; (5) adulthood. Lead...
Abstract Background The clinical implications of a diagnosis progressive transformation germinal centers (PTGC) in children are not well known. Methods To better understand this entity, we conducted retrospective review all patients aged 0–18 years diagnosed with PTGC at our center between 1998 and 2010. Results Twenty‐nine were identified. Median age was 11.5 years, median duration follow‐up 2.8 years. Thirteen (45%) had single episode no other associated features. Five (17%) recurrent...
Abstract Background Reports of responses and toxicities salvage therapies for relapsed neuroblastoma are rare often confounded by effects additional treatments. Our objective was to describe the outcomes a topotecan cyclophosphamide (TOPO/CTX) regimen first relapse or progression high‐risk neuroblastoma. Methods We retrospectively reviewed charts refractory patients treated between 1999 2009 with our standard‐of‐care outpatient TOPO/CTX (0.75 250 mg/m 2 /day × 5 days q3–4 weeks). Results...
Orthotopic liver transplantation (OLT) is considered the standard for children with hepatoblastoma (HB) in whom complete surgical resection not possible. However, OLT always available or feasible.To describe outcome of HB who were initially deemed unresectable and underwent complex hepatectomy planned close margins, ultimately avoided OLT.Demographic data, pathologic details, survival information collected from treated between January 2010 to December 2015.Among six (median age 12 months...
Abstract Extracranial germ cell tumors (GCT) are a biologically diverse group of occurring in children, adolescents, and young adults. The majority patients have excellent outcomes, but treatment‐related toxicities impact their quality survivorship. A subset succumbs to the disease. Current unmet needs include clarifying which can be safely observed after initial surgical resection, refinement risk stratification reduce chemotherapy burden with standard‐risk disease, intensify therapy for...