A5007425594- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Alkaloids: synthesis and pharmacology
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Epigenetics and DNA Methylation
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Mass Spectrometry Techniques and Applications
- Immune cells in cancer
- Analytical Chemistry and Chromatography
- Coordination Chemistry and Organometallics
- RNA modifications and cancer
- Cancer-related gene regulation
- Enzyme Catalysis and Immobilization
- Advanced Synthetic Organic Chemistry
- Axial and Atropisomeric Chirality Synthesis
- PARP inhibition in cancer therapy
- Ion-surface interactions and analysis
- Metal-Catalyzed Oxygenation Mechanisms
- DNA Repair Mechanisms
- Organometallic Complex Synthesis and Catalysis
Johns Hopkins University
2019-2025
Johns Hopkins Medicine
2019-2025
Royal Women's Hospital
2024
QIMR Berghofer Medical Research Institute
2018-2023
Sidney Kimmel Comprehensive Cancer Center
2019
University of Baltimore
2019
University of Bath
2000-2016
Royal Preston Hospital
2014
Indiana University – Purdue University Indianapolis
2010
University of Indianapolis
2010
An efficient, copper-based catalyst has been discovered that oxidizes a wide range of alcohols into aldehydes and ketones under mild conditions. This catalytic system utilizes oxygen or air as the ultimate, stoichiometric oxidant, producing water only by-product.
Abstract Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical importance. Here we show that quantitative BRCA1 methylation analysis provides new insight into PARPi response in preclinical models and cancer patients. The 12 HGSOC patient-derived xenografts (PDX) the rucaparib was assessed, variable dose-dependent responses observed chemo-naive BRCA1/2 -mutated PDX, no PDX...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEfficient, Aerobic, Ruthenium-Catalyzed Oxidation of Alcohols into Aldehydes and KetonesIstván E. Markó, Paul R. Giles, Masao Tsukazaki, Isabelle Chellé-Regnaut, Christopher J. Urch, Stephen M. BrownView Author Information Département de Chimie, Laboratoire Chimie Organique Université Catholique Louvain, Bâtiment Lavoisier Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium Zeneca Agrochemicals, Jealott's Hill Research Station Bracknell,...
An additive is the key to success: Catalytic amounts of N-methylimidazole are crucial for aerobic oxidation primary aliphatic alcohols in presence CuCl, 1,10-phenanthroline (phen), and di-tert-butyl azodicarboxylate (DBAD). This reaction, under neutral conditions, yields aldehydes quantitatively selectively without overoxidation carboxylic acids.
Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work demonstrated that DNMTi 5-Azacytidine (5AZA-C) activates type I interferon signaling to increase IFNγ+ T cells and natural killer (NK) reduce percentage of macrophages in tumor microenvironment. To improve efficacy epigenetic therapy, we hypothesized addition α-difluoromethylornithine (DFMO), an ornithine decarboxylase inhibitor, may further decrease immunosuppressive cell...
The oxidation of alcohols into aldehydes and ketones can be efficiently performed using catalytic amounts CuCl·Phen molecular oxygen or air. This novel, ecologically friendly procedure releases water as the only byproduct.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEfficient and Practical Catalytic Oxidation of Alcohols Using Molecular Oxygen†István E. Markó, Arnaud Gautier, Isabelle Chellé-Regnaut, Paul R. Giles, Masao Tsukazaki, Christopher J. Urch, Stephen M. BrownView Author Information Université catholique de Louvain, Département Chimie, Laboratoire Chimie Organique, Bâtiment Lavoisier, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium, Zeneca Agrochemicals, Jealott's Hill Research Station,...
The aerobic copper-catalyzed oxidation of alcohols such as 1 [Eq. (1)] functions even in the absence oxygen. Non-benzylic and secondary are further suitable substrates. A key role this reaction is played by azocarboxylates, which not only serve complex ligands but also hydride acceptors; bulky R groups tert-butyl particularly suitable.
The frequency, in women with breast cancer, of mutations and other variants the susceptibility gene, BRCA1, was investigated using a population-based case-control-family study. Cases were living Melbourne or Sydney, Australia, histologically confirmed, first primary, invasive diagnosed before age 40 years, recorded on state Cancer Registries. Controls without frequency-matched for age, randomly selected from electoral rolls. Full manual sequencing coding region BRCA1 conducted stratified...
Hypothermia (HT) is used clinically for neonatal hypoxic–ischemic encephalopathy (HIE); however, the brain protection incomplete and selective regional vulnerability lifelong consequences remain. Refractory damage impairment with HT cooling/rewarming could result from unchecked or altered persisting cell death proteinopathy. We tested two hypotheses: (1) modifies neurodegeneration type, (2) intrinsically disordered proteins (IDPs) cause toxic conformer protein (TCP) proteinopathy neonatally....
Allosteric proteins demonstrate the phenomenon of a ligand binding to protein at regulatory or effector site and thereby changing chemical affinity catalytic site. As such, allostery is extremely important biologically as mechanism for molecular concentrations in many cellular processes. One particularly interesting feature that often sites are separated by large distance. Structural comparisons allosteric resolved both inactive active states indicate variety structural rearrangement changes...
Death certificates of residents Alameda County, California (1958-1962) with any mention cancer were examined to determine the risk among beauticians. Twenty-four female beauticians found 3,460 adult females who died cancer; four in a sample 1,000 from causes other than cancer. The case and control matched for age race. resulting odds ratio (i.e., approximate relative death) was slightly elevated (1.73) but not statistically significant. Although possible increase several organ sites, lung...
Abstract Genetic studies of 540 Paraguayan Indians from nine tribal groups and 51 Mennonites are presented for ABO, MNSs, P 1 , Rh, Kell, Lewis, Duffy, Diego; serum immunoglobulins haptoglobins, G6PD‐deficiency, thalassemia trait. Group O gene frequencies all Indian were 1.00; r (cde) 0.00. Tapiete, Lengua, Toba, Sanapana R z ( CDE ) among the highest ever reported. N high Ache Kwera (Guayaki), Cheroti, Guarayu, Tapiete; s low Ayore. MS Sanapana, Ayore; Ns Tapiete. Diego was notably absent...
Ein Additiv als Schlüssel zum Erfolg: Katalytische Mengen N-Methylimidazol (NMI) sind entscheidend für die aerobe Oxidation primärer aliphatischer Alkohole in Gegenwart von CuCl, 1,10-Phenanthrolin (phen) und Di-tert-butylazodicarboxylat (DBAD). Unter neutralen Bedingungen erhält man quantitativ vollständig selektiv Aldehyde, ohne dass Weiteroxidation zu den Carbonsäuren eintritt.
The conditions which must be satisfied by an index of biological age are discussed, and a high correlation with chronological is shown to neither necessary nor sufficient condition any such index.