A5039297781- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- Organometallic Complex Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Coordination Chemistry and Organometallics
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Crystallography and molecular interactions
- Fluorine in Organic Chemistry
- Oxidative Organic Chemistry Reactions
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Metal complexes synthesis and properties
- Catalytic Alkyne Reactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalysis and Oxidation Reactions
- Carbohydrate Chemistry and Synthesis
- Organoboron and organosilicon chemistry
University of Nottingham
2016-2025
GlaxoSmithKline (United Kingdom)
2017-2023
University of Southampton
2023
University Hospitals of Derby and Burton NHS Foundation Trust
2020
Jubilee Hospital
2018
Universidad de Málaga
2018
Leibniz University Hannover
2018
Palacký University Olomouc
2018
Universidade de Santiago de Compostela
2018
Institute of Organic Chemistry with Centre of Phytochemistry
2018
Weigh it out in air! The DABAL reagent (Me3Al)2⋅(DABCO) (DABCO=1,4-diazabicyclo[2.2.2]octane) can be easily handled under normal laboratory conditions. Furthermore, chiral secondary alcohols efficiently prepared from prochiral aldehydes (see scheme; TOF=turnover frequency) by using either or AlR3 reagents (R=Me, Et). Thus, used as an efficient, convenient alternative to the Schumann–Blum reagent.
All for one and 1,4-all: Readily available aryl alanes are used in the rhodium-catalyzed asymmetric conjugate addition reaction with a variety of cyclic acyclic enones. The enhanced reactivity system allows use common binap ligand generation quaternary benzylic stereocenters excellent enantioselectivity (see scheme). Detailed facts importance to specialist readers published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made submitted by...
Thermoelectric generator composed of crystalline radical ion salts: The unipolar charge transport along the molecular stacks facilitates complementary p- and n-type organic thermoelectric materials high electrical conductivity 1D electronic structure. specific power output 5 mW cm-2 zT > 0.15 below 40 K demonstrate a new field low-temperature applications unlocked by metals.
The nucleophilic propargylation of azinium ions with a propargylboronate proceeds efficiently under gold(I) catalysis. A range N‐alkylated pyridinium, quinolinium, and pyrazinium undergo good yields high regioselectivities to give various functionalized 1,4‐dihydropyridines, 1,2‐dihydropyridines, 1,4‐dihydroquinolines, 1,2‐dihydroquinolines, 4,5‐dihydropyrazines. No allenylation side‐products are observed. Density functional theory (DFT) calculations provided insight into the mechanisms...
The range of chemical databases available has dramatically increased in recent years, but the reliability and quality their data are often negatively affected by human-error fidelity. size can make manual curation/checking such sets time consuming; thus, automated tools to help this process highly desirable. Herein, we propose use Graph Neural Networks (GNNs) identifying potential stereochemical misassignments primary asymmetric catalysis literature. Our method relies on an ensemble GNN...
A simple one-pot reaction of LiAlH4, AlCl3, and a secondary amine HNR2 [R = Et, iPr, iBu, cyclo-C6H11, (CH2)4, (CH2)5] in hydrocarbon solvents results the formation exogenous Lewis-base-free amidoalanes [H2Al(NR2)]n (n 2 or 3) as crystalline solids (35–85% yield). In solid state (seven X-ray structures), all exist dimers, with exception pyrrolidine-derived alane which exists trimer. As solids, these exhibit significant kinetic stability towards oxygen/moisture allowing brief (ca. 5 min.)...
2-Hydroxy-2'-alkylthio-1,1'-binaphthyl compounds are catalytic promoters of the 1,4-addition AlMe(3) to linear aliphatic enones in THF at -40 -48 degrees C presence [Cu(MeCN)(4)]BF(4). At ligand loadings 5-20 mol %, enantioselectivities 80-93 % realised for most substrates. To attain these values, use highly pure is mandatory. The methylalumoxane (MAO), derived by hydrolysis, leads reduced enantioselectivity and a conjugate addition product.
LiGaH4, in combination with the S,O-chelate 2-hydroxy-2'-mercapto-1,1'-binaphthyl (MTBH2), forms an active catalyst for asymmetric reduction of prochiral ketones, catecholborane as hydride source. Enantioface differentiation is on basis steric requirements ketone substituents. Aryl/ n-alkyl ketones are reduced 90-93% ee and RC(O)Me (e.g. R = iPr, cycloC6H11, tBu) 60-72% ee. Other borane sources alternative structures based indium do not form enantioselective catalysts.
Simple phosphoramidite ligands afford good to excellent levels of enantioselectivity in 1,4-additions AlR3 species enones; sequential carboalumination-ACA cascades are possible.
An extremely technically simple cross-methylation of aryl and vinyl halides pseudohalides using an air-stable adduct trimethylaluminium with a Pd(0) catalyst supported by commercially available biarylphosphines gives excellent yields methylated products (mainly >95%). Reactions can be run either 0.5 mol % or without requiring the exclusion atmospheric oxygen drying solvents in some cases. A wide variety functional groups is tolerated including CN, OH, CO2R, CHO NO2.
Abstract A new catalytic method for the synthesis of α‐hydroxyallenes is described. Efficient S N 2′ substitution propargylic dioxolanones has been achieved with a copper(I)/P(OBu) 3 catalyst using Grignard reagents as nucleophiles. The reaction tolerates wide variety dioxolanones, corresponding primary and secondary are obtained in good to excellent yields diastereoselectivity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
This review covers practical aspects of the preparation, handling and use all types amine N-oxides. It aims to provide both an encyclopedic overview general chemistry tertiary, hete...
The benefits of using machine learning approaches in the design, optimisation and understanding homogeneous catalytic processes are being increasingly realised. We focus on implementation key concepts, which serve as conduits to more advanced chemical literature, much is (presently) outside area catalysis. Potential pitfalls 'workflow' procedures needed process identified all examples provided a sciences context, including several from 'real world' catalyst systems. Finally, potential areas...
To synthesize novel more potent anti-diabetic agents.