A5044059419- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Folate and B Vitamins Research
- Neuroendocrine Tumor Research Advances
- Birth, Development, and Health
- Gastric Cancer Management and Outcomes
- Biliary and Gastrointestinal Fistulas
- Gestational Diabetes Research and Management
- Gastrointestinal Tumor Research and Treatment
- Renal cell carcinoma treatment
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Surgical Treatments
- Iron Metabolism and Disorders
- Adolescent and Pediatric Healthcare
- Protease and Inhibitor Mechanisms
- Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Cancer Cells and Metastasis
Erasmus MC
2008-2025
Erasmus MC Cancer Institute
2020-2024
Erasmus University Rotterdam
2008-2024
Leiden University Medical Center
2023
University Medical Center Groningen
2023
Erasmus MC Transplant Institute
2023
Reinier de Graaf Hospital
2020
Rotterdam University of Applied Sciences
2009
Pediatrics and Genetics
2008
We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals.From 2006 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater lifetime risk ductal adenocarcinoma (PDAC) after obligatory evaluation by a clinical geneticist and genetic testing, subjected them annual both endoscopic ultrasonography (EUS) MRI/cholangiopancreatography (MRI/MRCP) at each visit.366 (201 mutation-negative familial (FPC)...
Abstract Background Surgical resection followed by adjuvant mFOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) is currently the standard of care for patients resectable pancreatic cancer. The main concern regarding chemotherapy that only half actually receive treatment. Neoadjuvant chemotherapy, on other hand, guarantees early systemic treatment may increase use thereby improve overall survival. Furthermore, it prevent futile surgery in rapidly progressive disease....
Perihilar cholangiocarcinoma (pCCA) is a rare tumour that requires complex multidisciplinary management. All known data are almost exclusively derived from expert centres. This study aimed to analyse the outcomes of patients with pCCA in nationwide cohort.Data on all diagnosed Netherlands between 2010 and 2018 were obtained Cancer Registry. Data included type hospital diagnosis received treatment. Outcomes treatment overall survival.A total 2031 median survival for cohort was 5.2 (95% CI...
Importance Implementation of new cancer treatment strategies as recommended by evidence-based guidelines is often slow and suboptimal. Objective To improve the implementation guideline-based best practices in Netherlands pancreatic care assess impact on survival. Design, setting, participants This multicenter, stepped-wedge cluster randomized trial compared enhanced with usual consecutive patients all stages cancer. It took place from May 22, 2018 through July 9, 2020. Data were analyzed...
In high-risk individuals (HRIs), we aimed to assess the cumulative incidence of intraductal papillary mucinous neoplasms (IPMNs) and compare IPMN growth, neoplastic progression rate, value growth as predictor for these in sporadic IPMNs.
Eur J Clin Invest 2011; 41 (2): 143–150 Abstract Background Derangements in the maternal methylation pathway, expressed by global hypomethylation and hyperhomocysteinemia, are associated with risk of having a child congenital heart defect (CHD). It is not known whether periconception exposure to these metabolic derangements contributes chromosome segregation programming this pathway foetus. Design In Dutch population-based case–control study 143 children CHD 186 healthy children, we...
To investigate whether the association between maternal methylation status as reflected by low S-adenosylmethionine and high S-adenosylhomocysteine, is detrimental for cardiogenesis congenital heart disease (CHD) in offspring.As part of a case-control study western Netherlands, we evaluated 231 mothers children with CHD 315 control nonmalformed children. The total case group was analyzed stratified into isolated (n=180) nonisolated CHDs (n=51). latter subgroup further subdivided Nonsyndromic...
Abstract Background Postoperative pancreatic fistula is the main driver of morbidity and mortality after pancreatoduodenectomy. In high-risk patients, rate postoperative approaches 50%, whereas it below 5% in patients with cancer who receive neoadjuvant chemoradiotherapy. The aim this study was to evaluate safety, feasibility, efficacy preoperative stereotactic body radiotherapy on neck transection margin undergoing pancreatoduodenectomy prevent fistula. Methods prospective multicentre...
Abstract Background Pancreatic cancer has a very poor prognosis. Best practices for the use of chemotherapy, enzyme replacement therapy, and biliary drainage have been identified but their implementation in daily clinical practice is often suboptimal. We hypothesized that nationwide program to enhance these best pancreatic care would improve survival quality life. Methods/design PACAP-1 multicenter stepped-wedge cluster randomized controlled superiority trial. In per-center stepwise manner,...
To date, surveillance of high-risk individuals for pancreatic ductal adenocarcinoma (PDAC) has not lived up to expectations, as identification curable stages through imaging remains challenging. Biomarkers are therefore needed. Pancreatic juice (PJ) may be a promising source, because it is in direct contact with the epithelial lining from which PDAC arises. We aimed develop panel biomarkers serum and PJ detect future purposes.All patients who underwent collection on secretin stimulation at...
BackgroundMost data on the treatment and outcomes of intrahepatic cholangiocarcinoma (iCCA) derives from expert centers. This study aimed to investigate all patients diagnosed with iCCA in a nationwide cohort.MethodsData between 2010 2018 were obtained Netherlands Cancer Registry.ResultsIn total, 1747 included. Resection was performed 292 (17%), 548 (31%) underwent palliative systemic treatment, 867 (50%) best supportive care (BSC). The OS median 1-, 3-year after resection: 37.5 months...
Congenital heart defects (CHDs) have a multifactorial origin, in which subtle genetic factors and peri-conception exposures interact. We hypothesize that derangements the homocysteine detoxification pathways, due to polymorphism nicotinamide N-methyltransferase (NNMT) gene, low maternal dietary intake, medicine use period, affect CHD risk. In 292 case 316 control families, intake of (≤13.8 mg/day) were independently associated with risk [odds ratio (95% confidence interval) 1.6 (1.1–2.3) 1.5...
The methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with complex congenital malformations. Whether these CHDs is not clear. We studied both MTHFR polymorphisms, folate vitamin B2 by maternal food intake supplements, CHD risk.A case-control family study was conducted in a European population the Netherlands including 230 case 251 control children parents. Approximately 17 months after index pregnancy, mothers filled out standardized questionnaires on...
INTRODUCTION: Imaging-based surveillance programs fail to detect pancreatic ductal adenocarcinoma at a curable stage, creating an urgent need for diagnostic biomarkers. METHODS: Secretin-stimulated juice (PJ) was collected from the duodenal lumen during endoscopic ultrasound. The yield of biomarkers and organoids compared 2 collection techniques (endoscope suction channel vs catheter-based) 3 periods (0–4 4–8 8–15 minutes). RESULTS: Collection through endoscope superior with catheter. beyond...
For a highly selected group of patients with unresectable perihilar cholangiocarcinoma (pCCA), liver transplantation (LT) is treatment option. The Dutch screening protocol comprises nonregional lymph node (LN) assessment by EUS, and whenever LN metastases are identified, further LT precluded. aim this study to investigate the yield EUS in pCCA who potentially eligible for LT.
Abstract Introduction Duodenal stent placement is a palliative option for management of malignant gastric outlet obstruction (GOO). In the last 20 years, gastrointestinal cancers has considerably changed. It unknown if these changes have affected clinical outcome duodenal placement. Methods Retrospective cohort study conducted in tertiary referral center. Patients who underwent GOO-symptoms due to stricture were included. Primary was GOO-symptom free survival. Secondary outcomes included...