A5058222437- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Biological Research and Disease Studies
- Lung Cancer Research Studies
- Cancer Research and Treatment
- Childhood Cancer Survivors' Quality of Life
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Multiple and Secondary Primary Cancers
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Colorectal Cancer Surgical Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Bowel Disease
- Radiomics and Machine Learning in Medical Imaging
- Respiratory and Cough-Related Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Infant Health and Development
- Liver Disease Diagnosis and Treatment
Erasmus MC
2019-2024
Erasmus University Rotterdam
2021-2023
Erasmus MC Cancer Institute
2021-2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
RELX Group (Netherlands)
2022
Noordwest Ziekenhuisgroep
2020
The Netherlands Cancer Institute
2019
Karolinska Institutet
2014
We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals.From 2006 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater lifetime risk ductal adenocarcinoma (PDAC) after obligatory evaluation by a clinical geneticist and genetic testing, subjected them annual both endoscopic ultrasonography (EUS) MRI/cholangiopancreatography (MRI/MRCP) at each visit.366 (201 mutation-negative familial (FPC)...
To successfully implement imaging-based pancreatic cancer (PC) surveillance, understanding the timeline and morphologic features of neoplastic progression is key. We aimed to investigate neoplasia from serial prediagnostic imaging tests in high-risk individuals identify factors associated with successful early detection.We retrospectively examined development abnormalities who were diagnosed PC or underwent surgery, both, 16 international surveillance programs.Of 2552 under 28 (1%) developed...
In high-risk individuals (HRIs), we aimed to assess the cumulative incidence of intraductal papillary mucinous neoplasms (IPMNs) and compare IPMN growth, neoplastic progression rate, value growth as predictor for these in sporadic IPMNs.
To date, surveillance of high-risk individuals for pancreatic ductal adenocarcinoma (PDAC) has not lived up to expectations, as identification curable stages through imaging remains challenging. Biomarkers are therefore needed. Pancreatic juice (PJ) may be a promising source, because it is in direct contact with the epithelial lining from which PDAC arises. We aimed develop panel biomarkers serum and PJ detect future purposes.All patients who underwent collection on secretin stimulation at...
Abstract Background Surveillance of pancreatic cysts focuses on the detection (mostly morphologic) features warranting surgery. European guidelines consider elevated CA19.9 as a relative indication for We aimed to evaluate role monitoring early and management in cyst surveillance population. Methods The PACYFIC‐registry is prospective collaboration that investigates yield performed at discretion treating physician. included participants whom least one serum value was determined by minimum...
Summary Background Allergy and immune dysregulation may have a role in the pathophysiology of recurrent abdominal pain functional origin, but previous studies allergy‐related diseases contradictory results. Aim To examine association between or sensitisation during childhood at age 12 years. Methods In this birth cohort study 4089 children, parents answered questionnaires regarding asthma, allergic rhinitis, eczema food hypersensitivity (‘allergy‐related diseases’) ages 0,1,2,4,8 Blood for...
Estimates on the progression of precursor lesions to pancreatic cancer (PC) are scarce. We used microsimulation modeling gain insight into natural disease course PC and its precursors. This information is pivotal explore efficacy screening.
Surveillance of individuals at risk developing pancreatic ductal adenocarcinoma (PDAC) has the potential to improve survival, yet early detection based on solely imaging modalities is challenging. We aimed identify changes in serum glycosylation levels over time earlier detect PDAC high-risk individuals. Individuals with a hereditary predisposition develop were followed two surveillance programs. Those, which least consecutive samples available, included. Mass spectrometry analysis was...
As the impact of unmanaged bias (i.e. systematic source inaccuracy) in fecal immunochemical test (FIT) analytical performance on long-term colorectal cancer (CRC) outcomes is unknown, we assessed FIT an ongoing FIT-based CRC screening program. This study consisted two parts: cross-sectional observational data analysis to estimate change short-term and microsimulation modelling assuming different levels by 15 % lower up higher Hemoglobin detected stool compared observed. Two scenarios were...
Abstract Pancreatic cancer (PC) survival is poor, as detection usually occurs late, when treatment options are limited. Screening of high‐risk individuals may enable early and a more favorable prognosis. Knowledge gaps prohibit establishing the effectiveness screening. We developed Microsimulation Analysis model to analyze impact relevant uncertainties on effect PC screening in individuals. The simulates two base cases: one which lesions always progress indolent faster progressive coexist....
INTRODUCTION: Several studies suggest that new-onset diabetes mellitus is an early manifestation of pancreatic ductal adenocarcinoma (PDAC). Therefore, the International Cancer Pancreas Screening Consortium recommends glucose and hemoglobin A1c (HbA1c) monitoring in high-risk individuals (HRIs) undergoing surveillance. However, evidence such improves PDAC detection lacking. Our aim was to investigate association between serum HbA1c values development HRIs METHODS: Participants were recruited...
Background: Surveillance of individuals at risk developing pancreatic ductal adenocarcinoma (PDAC) has the potential to improve survival, yet early detection based on solely imaging modalities is challenging. Alternatively, with lesions progressing malignancy can be recognized by molecular biomarkers. We aimed identify changes in serum protein glycosylation levels over time earlier detect PDAC high-risk undergoing surveillance.Methods: Individuals a hereditary predisposition develop were...