A5053339659- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Biochemical and Molecular Research
- Cytomegalovirus and herpesvirus research
- Signaling Pathways in Disease
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- Inflammatory Bowel Disease
- Nuclear Receptors and Signaling
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastrointestinal Bleeding Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Pancreatic function and diabetes
- Sarcoidosis and Beryllium Toxicity Research
- Histone Deacetylase Inhibitors Research
- Neuroendocrine Tumor Research Advances
- Autoimmune and Inflammatory Disorders
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Esophagitis
Addenbrooke's Hospital
2013-2022
University of Cambridge
2006-2022
MRC Epidemiology Unit
2021
Cambridge School
2020
University of Birmingham
2010-2016
Immune Regulation (United Kingdom)
2010-2013
Wellcome Trust
2013
Sandwell & West Birmingham Hospitals NHS Trust
2011
IgG antibodies cause inflammation and organ damage in autoimmune diseases such as systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages isolated from inflamed tissues immune complex (IC)-associated diseases, including SLE rheumatoid arthritis, following Fcγ receptor cross-linking. found that human mouse undergo a switch to glycolysis response IC stimulation, mirroring macrophage changes tissue vivo. This reprogramming was required generate number...
Early identification of patients with rheumatoid arthritis (RA) is essential to allow the prompt institution therapy. The 2010 American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria, which replace 1987 have been developed facilitate such in newly presenting inflammatory arthritis. This study therefore assesses performance these new criteria early synovitis.Data were analysed from synovitis seen within 3 months onset Patients followed for 18...
Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as critical regulator of patients IBD and mice dextran sodium sulfate (DSS)-induced colitis. We find that GM-CSF drives the maturation polarization macrophages, promoting anti-microbial functions while suppressing wound-healing transcriptional programs. Group 3 innate...
A GPCR–Na/K-ATPase interaction alters metabolism and proliferation to enhance intestinal tumor formation.
Mutations in FAMIN cause arthritis and inflammatory bowel disease early childhood, a common genetic variant increases the risk for Crohn's leprosy. We developed an unbiased liquid chromatography-mass spectrometry screen enzymatic activity of this orphan protein. report that phosphorolytically cleaves adenosine into adenine ribose-1-phosphate. Such was considered absent from eukaryotic metabolism. its prokaryotic orthologs additionally have deaminase, purine nucleoside phosphorylase,...
Still's disease, the paradigm of autoinflammation-cum-autoimmunity, predisposes for a cytokine storm with excessive T lymphocyte activation upon viral infection. Loss function purine nucleoside enzyme FAMIN is sole known cause monogenic disease. Here we discovered that FAMIN-enabled metabolon in dendritic cells (DCs) restrains CD4+ and CD8+ cell priming. DCs absent activity prime enhanced antigen-specific cytotoxicity, IFNγ secretion, expansion, resulting influenza A virus-specific...
ObjectivesTenosynovitis (TS) is common in early arthritis. However, the value of US-defined TS predicting RA development unclear. We assessed predictive utility alongside synovitis and clinical serological variables a prospective cohort arthritis patients.
In neurons, the second messengers Ca(2+) and cAMP are mediators of transcriptional responses that important for development function nervous system. The pro-survival neuronal transcription factors cAMP-response elementbinding protein (CREB) myocyte enhancer factor-2 (MEF2) both stimulate gene expression in response to activity-dependent increases concentration intracellular ions. CREB is also activated by cAMP. Here we have investigated whether MEF2 family member MEF2D, similar CREB,...
In the mammalian hippocampus, changes in expression of immediate early genes (IEGs) is thought to contribute long term plastic neurons brought about by learning tasks and high frequency stimulation synapses. The phosphatase calcineurin has emerged as an important negative regulator hippocampus-dependent potentiation. Here we investigated possibility that constraining action on hippocampal plasticity mediated part regulation gene through control transcription factors, such cAMP-response...
Abstract Background Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific for RA, but not detectable in all RA patients. The aim of this study was to establish whether the clinical phenotypes anti-CCP positive and negative disease distinct at earliest clinically apparent phase disease. Methods Patients were recruited from Birmingham early inflammatory arthritis clinic. Participants included current if they presented within 3 months symptom onset fulfilled 1987 ACR...
<h3>Background</h3> The EULAR Study Group for Risk Factors Rheumatoid Arthritis (RA) recommends identification of new biomarkers prediction RA in early undifferentiated disease. OMERACT Ultrasound Task Force recently established that US is a reproducible tool evaluating tenosynovitis (TS) RA<sup>1</sup>, which common manifestation RA. At present, the value US-defined TS unknown. <h3>Objectives</h3> To explore ability to predict compared with clinical and serological variables an unselected...
<h3>Background</h3> Early identification of patients at risk persistent as opposed to spontaneously resolving arthritis is essential allow the prompt institution therapy and provide vital information from patient's perspective. Currently available prediction strategies for disease include that developed by Visser et al<sup>1</sup>. The biomarkers can improve such an important goal. We have previously shown data ultrasound joint assessment adds accuracy Leiden Rule RA. Here we present on...
<h3>Background</h3> Tenosynovitis (TS) is a common manifestation of rheumatoid arthritis and postulated to be an early marker disease but requires imaging reliably detect its presence. The prevalence tenosynovitis in patients with very unknown there have been no studies on as predictor the development either (RA) or persistent disease. <h3>Objectives</h3> 1) establish assessed by ultrasound unselected arthritis, 2) explore whether presence defined improves prediction RA persistence compared...
evidence justifying a thorough discussion among experts on the regular use of low-dose aspirin in CHB or CHC patients.
<h3>Background</h3> Prediction of disease persistence in early inflammatory arthritis is important to enable timely initiation appropriate therapy. Currently available predictive algorithms for persistent do not include US variables. We used a data-driven method identify the minimal core set US, clinical and serological variables predicting cohort patients with arthritis. <h3>Methods</h3> 107 [female n = 60, median age 51] ≥1 clinically apparent synovitis symptom duration ≤3 months underwent...
<h3>Background and objective</h3> Tenosynovitis is common in early arthritis the OMERACT Ultrasound Task Force recommended that US a reproducible tool for evaluating tenosynovitis (TS) RA. However, value of US-defined prediction RA development unclear. We assessed ability TS to predict persistent prospective cohort patients with arthritis. <h3>Methods</h3> 107 clinically apparent synovitis at least one joint symptom duration ≤3 months underwent baseline clinical, laboratory tendon...