A5036790143- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Systemic Lupus Erythematosus Research
- Synthesis and Reactions of Organic Compounds
- Health Systems, Economic Evaluations, Quality of Life
- Synthesis and biological activity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psoriasis: Treatment and Pathogenesis
- Biosimilars and Bioanalytical Methods
- Spondyloarthritis Studies and Treatments
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Vasculitis and related conditions
- Animal Virus Infections Studies
- Sarcoidosis and Beryllium Toxicity Research
- Tuberculosis Research and Epidemiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Multicomponent Synthesis of Heterocycles
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cytomegalovirus and herpesvirus research
- Lanthanide and Transition Metal Complexes
- Mycobacterium research and diagnosis
University of Birmingham
2018-2024
Sandwell & West Birmingham Hospitals NHS Trust
2022-2024
University Hospitals Birmingham NHS Foundation Trust
2018-2023
NIHR Birmingham Biomedical Research Centre
2023
Versus Arthritis
2022
Queen Elizabeth Hospital Birmingham
2018-2021
Robert Jones and Agnes Hunt Orthopaedic Hospital
2020
Royal Shrewsbury Hospital
2020
Teerthanker Mahaveer Medical College & Research Centre
2016
Chaudhary Charan Singh Haryana Agricultural University
1989-1995
ObjectivesTenosynovitis (TS) is common in early arthritis. However, the value of US-defined TS predicting RA development unclear. We assessed predictive utility alongside synovitis and clinical serological variables a prospective cohort arthritis patients.
Rheumatoid arthritis (RA) is often preceded by symptomatic phases during which classification criteria are not fulfilled. The health burden of these "at-risk" stages well described. This study assessed health-related quality life (HRQoL), function, fatigue and depression in newly presenting patients with clinically suspect arthralgia (CSA), unclassified (UA) or RA.
Abstract In the case of H5N1 avian influenza outbreak, specific detection is critical for timely implementation control and preventive measures to limit spread disease. Sample collection, storage, transportation are accurate virus as its isolation identification can only be done in a designated laboratory. this study, we have compared 5 transport media out which three laboratory-based named Phosphate-buffered Saline (PBS), 50% Glycerol + PBS, Normal (NS) two commercially available including...
The role of fibroblasts in determining tissue topography and immune cell organisation within chronically inflamed tissues is poorly understood. Herein, we use multi-omic spatial analysis to define the cellular zonation pattern synovium patients with inflammatory arthritis, identifying discrete niches underpinned by spatially programmed subsets synovial fibroblasts. We observe that perivascular switch on distinct matrix programs response cytokine signalling from neighbouring cells, forming...
Abstract Objectives The value of US-defined tenosynovitis in predicting the persistence inflammatory arthritis is not well described. In particular, predictive utility larger tendons yet to be reported. We assessed alongside synovitis and clinical serological variables persistent an inception cohort DMARD-naïve patients with early arthritis. Methods One hundred fifty clinically apparent one or more joints a symptom duration ≤3 months underwent baseline clinical, laboratory US (of 19...
Interstitial lung disease (ILD) is a well-known extra-articular manifestation in patients diagnosed with rheumatoid arthritis (RA). The cardinal symptom of ILD dyspnoea. There are several drugs which have been implicated the development or exacerbation ILD. Disease-modifying antirheumatic
An 80-year-old man presented repeatedly to his general practitioner with 3 months of unexplained persistent frontal headaches. CT head revealed no diagnosis. His dentist diagnosed co-existing jaw pain as bruxism. Three later, the patient happened attend a routine ophthalmology follow-up appointment. During this appointment, features giant cell arteritis (GCA) including worrying visual complications were first noted. inflammatory markers (C-reactive protein and erythrocyte sedimentation rate)...
Since tubercular lesions form an important differential diagnosis in our country, tuberculoma models mice have been created and imaged using iodine-125 radiolabelled antimycobacterial monoclonal antibodies for the aetiopathological diagnosis.
Despite recent advances with the introduction of biologic/targeted synthetic disease modifying anti-rheumatic drugs (b/tsDMARDs); there is a growing number individuals rheumatoid arthritis (RA) in whom stepwise escalation current treatment modalities remain ineffective1. Improvement activity can be impacted by inflammatory and non-inflammatory components, thus improving outcomes this cohort patients relies on holistic care. Recently, European Alliance Associations for Rheumatology (EULAR)...
Abstract Background/Aims Estimates predict between 10-20% of RA patients meet difficult-to-treat Rheumatoid Arthritis (D2T-RA) classification, representing a clinically distinct cohort. There is significant unmet need in the identification and management these patients. Discerning characteristics across cohorts may identify predictors for D2T-RA, which prompt earlier clinical recognition patient-tailored, holistic to improve outcomes. This review aims describe with EULAR-defined D2T-RA help...
The Experiment was conducted during June–December, 2022 at Department of Veterinary Public Health & Epidemiolgy, College Science Animal Husbandry, Rewa, NDVSU, Jabalpur, M.P. India. to attribute the possible risk poultry and its product as an increasing cause for food borne Salmonellosis, a cross sectional study carried out in samples from Rewa city Madhya Pradesh. A total 300 sample (Poultry environment) were collected processed isolation identification Salmonellae by culture,...
<h3>Background:</h3> Multiple factors may contribute to the development of difficult-to-treat rheumatoid arthritis (D2T-RA) including medication-taking behaviours [1]. Non-adherence medication is accompanied by poorer therapeutic response, which in turn can lead subsequent drug discontinuation and frequent switching. Therefore, maximize utility biologic DMARDS (bDMARDs) before onset D2T disease, it important tackle issue non-adherence. Exploring rates reasons for non-adherence bDMARDs...
Giant cell arteritis (GCA) is a vasculitis caused by immune cascades resulting in vascular inflammation, remodelling and vessel occlusion, therefore cause of arteritic anterior ischaemic optic neuropathy.[1][1] Characteristically, it accompanied headaches, jaw claudication, scalp
Background: Biological therapy plays a major role in the management of patients with rheumatic disorders. Evidences generated at experimental settings have shown biosimilars as clinically effective, safe and cost effective. Nevertheless, real world data are lacking about effectiveness causes switching back to originator product among Objectives: To describe associated factors evaluation etanercept from biosimilar disorders The Robert Jones Agnes Hunt Orthopaedic Hospital United Kingdom...
Cutaneous lesions and skin rashes are commonly encountered on the acute take in medical units. Sweet syndrome (SS) is an uncommon inflammatory disorder, originally described as 'acute febrile neutrophilic dermatosis' by Sweet.[1][1] There numerous aetiological associations reported
Psoriasis is a chronic inflammatory autoimmune skin disease characterized by immune-mediated cutaneous inflammation and keratinocyte hyperproliferation. can be the early presenting manifestation in patients with human immunodeficiency virus (HIV) infection, acquired syndrome. We report three severe extensive psoriatic lesions, arthritis, cachehxia, oesophagitis, “Tambaram tongue” whom initial serological testing for HIV was negative, but Westernblot test confirmed diagnosis of infection.
Abstract Background/Aims Rheumatoid arthritis (RA) is often preceded by symptomatic phases during which classification criteria are not fulfilled. The health burden of these “at-risk” stages well described. This study assessed health-related quality life (HRQoL), functioning, fatigue and depression in newly presenting patients with clinically suspect arthralgia (CSA), unclassified (UA) RA. Methods Cross-sectional analysis baseline Patient-Reported Outcome Measures (PROMs) was conducted 838...
<h3>Background</h3> Management of difficult-to-treat rheumatoid arthritis (D2T-RA) is challenging since poor treatment response also incorporates non-inflammatory symptoms that can mimic or amplify pain and scores on composite disease activity measures. Identification modifiable factors vital to improve health outcomes minimise harm from inappropriate escalation drug therapy. <h3>Objectives</h3> To develop assess feasibility a systematic, evidence-based clinical assessment tool for the...