A5040263407- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- Polyamine Metabolism and Applications
- Radiopharmaceutical Chemistry and Applications
- Lipid metabolism and biosynthesis
- Mitochondrial Function and Pathology
- Parasitic Diseases Research and Treatment
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Bacterial Infections and Vaccines
- Cellular transport and secretion
- Epigenetics and DNA Methylation
- Whipple's Disease and Interleukins
- Clostridium difficile and Clostridium perfringens research
- Cannabis and Cannabinoid Research
- Urinary Tract Infections Management
- Fuel Cells and Related Materials
- Escherichia coli research studies
- Marine Biology and Environmental Chemistry
- Microplastics and Plastic Pollution
- Calcium signaling and nucleotide metabolism
- Cerebrovascular and genetic disorders
- Cassava research and cyanide
- Photosynthetic Processes and Mechanisms
University of Michigan
2017-2023
Sarojini Naidu Medical College
1978-2010
National Taiwan University
2010
Proline (Pro) accumulation is a common response of several plant species to combat abiotic stresses. Under stress conditions, Pro acts as an excellent compatible solute in the system, participating alleviation sensitivity. Though metabolic pathways associated with are well studied, parts its regulatory cascades still not properly known. It has also been conjectured that epigenetic modifications regulate metabolism during stress. Apart from Pro, responses essentially mediated by multiple...
Microfilariae of Wuchereria bancrofti were detected in seven cases anemia persons with asymptomatic filariasis. In three microfilariae could not be the blood. Their presence bone marrow may indicate ability to cross vessel wall.
Phosphoinositide signaling lipids are essential for several cellular processes. The requirement a phosphoinositide is conventionally studied by depleting the corresponding lipid kinase. However, there very few reports on impact of elevating phosphoinositides. That phosphoinositides dynamically elevated in response to stimuli suggests that, addition being required, drive downstream pathways. To test this hypothesis, we levels phosphatidylinositol-3-phosphate (PI3P) generating hyperactive...
Mitophagy is a conserved and highly regulated process of selective degradation crucial in maintaining normal cellular physiology. Genetic defects aberrations affecting mitophagy have been associated with the development Parkinson disease. In their recently published article (highlighted punctum this issue journal) Hsieh et al. present putative marker, which serves as mechanistic link between sporadic familial
Macroautophagy/autophagy is a highly conserved nutrient-recycling pathway that eukaryotes utilize to combat diverse stresses including nutrient depletion. Dysregulation of autophagy disrupts cellular homeostasis leading starvation susceptibility in yeast and disease development humans. In yeast, the robust response controlled by upregulation ATG genes, via regulatory processes involving multiple levels gene expression. Despite identification several regulators through genetic studies,...
The Atg12 protein in yeast is an indispensable polypeptide the highly conserved ubiquitin-like conjugation system operating macroautophagy/autophagy pathway. covalently conjugated to Atg5 through action of Atg7 and Atg10; Atg12–Atg5 conjugate binds Atg16 form E3 ligase that functions a separate pathway involving Atg8. comprised (UBL) domain preceded at N terminus by intrinsically disordered region (IDPR), comprises major portion but remains elusive its conformation function. Here, we show...
The impact of recent advances in the chemical and genetic engineering manipulations antibodies on radioimmunotargeting is reviewed both relation to radioimmunoscintigraphy radioimmunotherapy. resulting trends are: (1) linking parts mouse/rat human antibody molecule; (2) creation molecules with dual antigen or multiple recognition capabilities; (3) making smaller molecules; (4) development capabilities, e.g. enzyme activity. various methods creating vitro are reference bacteria, using phage...
A patient presented with hyperthyroidism and a thyroid swelling, clinically thought to be malignant. Fine-needle aspiration of the nodule revealed microfilariae Wuchereria bancrofti. After therapy swelling subsided became euthyroid. The possible etiologic role in genesis tumor is discussed. Diagn. Cytopathol. 16:149–150, 1997. © 1997 Wiley-Liss, Inc.
Since tubercular lesions form an important differential diagnosis in our country, tuberculoma models mice have been created and imaged using iodine-125 radiolabelled antimycobacterial monoclonal antibodies for the aetiopathological diagnosis.
A histomorphologic study was done at intervals up to 10 days after causing a fracture in both hindleg tibiae dogs and giving direct electrical stimulation one tibia, the other being used as control (20 microns ampere of current were passed 28 limbs maintained with help simple regulator developed by authors). The radiologic showed definite evidence early start completion healing processes electrically stimulated hindlegs. Negative potentials induced sites appeared be cause improved healing....