A5015799471- Cytomegalovirus and herpesvirus research
- Adenosine and Purinergic Signaling
- Biochemical and Molecular Research
- Gut microbiota and health
- Nanoparticle-Based Drug Delivery
- Pancreatitis Pathology and Treatment
- Sphingolipid Metabolism and Signaling
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- 3D Printing in Biomedical Research
- Immune Cell Function and Interaction
- Polymer Surface Interaction Studies
- Veterinary medicine and infectious diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Infant Nutrition and Health
University of Duisburg-Essen
2019-2023
Kiel University
2020
Mutations in FAMIN cause arthritis and inflammatory bowel disease early childhood, a common genetic variant increases the risk for Crohn's leprosy. We developed an unbiased liquid chromatography-mass spectrometry screen enzymatic activity of this orphan protein. report that phosphorolytically cleaves adenosine into adenine ribose-1-phosphate. Such was considered absent from eukaryotic metabolism. its prokaryotic orthologs additionally have deaminase, purine nucleoside phosphorylase,...
A wide range of microbial pathogens is capable entering the gastrointestinal tract, causing infectious diarrhea and colitis. finely tuned balance between different cytokines necessary to eradicate threat avoid infection complications. The current study identified IL-33 as a critical regulator immune response enteric pathogen Citrobacter rodentium. We observed that deficiency signaling pathway attenuates bacterial-induced Conversely, boosting this strongly aggravates inflammatory makes mice...
Abstract Ultrasmall gold nanoparticles (2 nm) easily penetrate the membranes of intestinal murine epithelial cells (MODE‐K) and colorectal cancer (CT‐26). They are also taken up by 3D spheroids (400 µm) these cell types primary gut organoids (500 µm). In contrast, dissolved dyes not any or structures. The distribution fluorescent ultrasmall inside cells, spheroids, is examined confocal laser scanning microscopy. Nanoparticles conjugated with cytostatic drug doxorubicin a dye exhibit...
Abstract Primary and recurrent cytomegalovirus (CMV) infections frequently cause CMV colitis in immunocompromised as well inflammatory bowel disease (IBD) patients. Additionally, occasionally occurs upon primary infection patients who are apparently immunocompetent. In both cases, the underlying pathophysiologic mechanisms largely elusive ‐ part due to lack of adequate access specimens. We employed mouse (MCMV) model assess association between colitis. During acute MCMV immunocompetent mice,...
Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs patients ulcerative colitis is discussed to contribute its pathogenesis. In present study, we determined impact acid sphingomyelinase (Asm), which catalyzes hydrolysis sphingomyelin ceramide course Citrobacter (C.) rodentium-driven colitis. C. rodentium an enteric pathogen induces colonic inflammation...
The incidence of gastrointestinal infections continues to increase, and infectious colitis contributes significantly morbidity mortality worldwide. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been discovered be strongly involved in the intestinal homeostasis. However, whether CEACAM1 expression an impact on control remains elusive. Citrobacter rodentium (C. rodentium) is a gram-negative enteric pathogen that induces colonic inflammation mice, with critical role...
Ultrasmall Gold Nanoparticles Three-dimensional cell culture models represent a bridge between conventional two-dimensional studies and in-vivo animal experiments. In article number 2201167, Astrid M. Westendorf, Matthias Epple, co-workers demonstrate the cytostatic action of doxorubicin-carrying ultrasmall gold nanoparticles, including their superior ability to enter three-dimensional cultures compared dissolved drugs.
Abstract Primary and recurrent cytomegalovirus (CMV) infections frequently cause CMV colitis in immunocompromised as well inflammatory bowel disease (IBD) patients. Additionally, occasionally occurs upon primary infection patients who are apparently immunocompetent. In both cases, the underlying pathophysiologic mechanisms largely elusive - part due to lack of adequate access specimens. We employed mouse (MCMV) model probe into association between colitis. During acute MCMV immunocompetent...