A5078436496- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Cancer Treatment and Pharmacology
- Connective tissue disorders research
- GDF15 and Related Biomarkers
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular and Diving-Related Complications
- Acute Ischemic Stroke Management
- Respiratory Support and Mechanisms
- Sports Performance and Training
- Spaceflight effects on biology
Akershus University Hospital
2016-2025
University of Oslo
2016-2025
University Kebangsaan Malaysia Medical Centre
2023
Oslo University Hospital
1994-2021
Smerteklinikken
2017
Lund University
2014
Türkiye Yüksek İhtisas Hastanesi
2013
Seoul National University Hospital
2013
Azienda Ospedaliero Universitaria San Giovanni Battista
2013
University of Turin
2013
Contemporary adjuvant treatment for early breast cancer is associated with improved survival but at the cost of increased risk cardiotoxicity and cardiac dysfunction. We tested hypothesis that concomitant therapy angiotensin receptor blocker candesartan or β-blocker metoprolol will alleviate decline in left ventricular ejection fraction (LVEF) adjuvant, anthracycline-containing regimens without trastuzumab radiation. In a 2 × factorial, randomized, placebo-controlled, double-blind trial, we...
The impact of recent consensus definitions cancer therapy-related cardiac dysfunction (CTRCD) from the European Society Cardiology cardio-oncology guidelines on reported incidence CTRCD has not yet been assessed.
Background — Tissue Doppler imaging (TDI) is a potentially powerful method for diagnosing myocardial ischemia. This study was designed to investigate how velocity patterns in ischemic myocardium relates regional function, and determine whether timing of measurements relative ejection isovolumic phases may increase the diagnostic power TDI. Methods Results In 17 open-chest anesthetized dogs we measured pressures by micromanometers, longitudinal segment lengths sonomicrometry, velocities...
The present study aimed to explore the prevalence of pre-capillary pulmonary hypertension (PH) and characterise haemodynamic vascular responses physical exercise in chronic obstructive disease (COPD) outpatients, where left ventricular dysfunction comorbidities were excluded. 98 patients with COPD underwent right heart catheterisation at rest during supine exercise. Mean artery pressure ( P pa ), capillary wedge pcw ) cardiac output (CO) measured Exercise-induced increase mean was...
Adjuvant breast cancer therapy containing anthracyclines with or without anti-human epidermal growth factor receptor-2 antibodies and radiotherapy is associated treatment-related cardiac dysfunction. In the PRADA trial (Prevention of Cardiac Dysfunction During Breast Cancer Therapy), concomitant treatment angiotensin receptor blocker candesartan attenuated reduction in left ventricular ejection fraction (LVEF) women receiving for cancer, whereas β-blocker metoprolol increase troponins. This...
Background Anthracyclines are associated with cardiotoxic effects. Cardiovascular biomarkers may reflect myocardial injury, dysfunction, inflammation, and fibrosis precede predict the development of left ventricular impairment. The aim this study was to assess: (1) longitudinal change in circulating cardiovascular biomarkers, (2) effect metoprolol succinate candesartan cilexetil on biomarker response, (3) associations between on‐treatment changes concentrations subsequent dysfunction...
Abstract Aims Studies with implantable cardiac monitors (ICMs) show that one-third of patients cryptogenic stroke/transient ischaemic attack (TIA) have episodes subclinical atrial fibrillation (SCAF) and benefit switching from antiplatelet- to anticoagulant therapy. However, ICMs are costly resource demanding. We aimed build a score based on participant’s baseline characteristics could assess individual risk SCAF. Methods results In prospective study, 236 eligible final diagnosis stroke/TIA...
Persistent dyspnea, functional limitations, and reduced quality of life (QoL) are common following pulmonary embolism (PE). Rehabilitation is a potential treatment option, but the scientific evidence limited.
Abstract Background Cardiac myosin binding protein C (cMyC) is a novel, cardiac-specific biomarker with an early release profile after acute ischemic myocardial injury. Whether cMyC reflects chronic injury and left ventricular remodelling in the general population unknown. The aims of study were to test hypotheses that concentrations are associated cardiovascular risk factors, biomarkers injury, imaging cardiac anatomy, function, fibrosis. Methods Circulating troponin I T measured 3672...
<b><i>Objective:</i></b> The PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA) study is a randomized, placebo-controlled, double-blind trial to determine whether angiotensin receptor blockers (ARB), or beta-blockers their combination may prevent the development left ventricular (LV) dysfunction in patients on standard adjuvant treatment for early cancer. <b><i>Methods:</i></b> Following surgical resection, 120...
Abuse of anabolic-androgenic steroids (AAS) has been linked to a variety different cardiovascular (CV) side effects, but still the clinical effects AAS abuse on CV risk are not clear. The aim this study was assess phenotype large cohort men with long-term use compared strength-trained athletes without use.Fifty one ≥3 years twenty competing athletes. We verified substance and non-abuse by blood urine analyses. participants underwent comprehensive evaluation including laboratory analyses,...
Background —We examined the hypothesis that retardation of apical filling as measured by color M-mode Doppler echocardiography in diseased left ventricle (LV) reflects a decrease intraventricular mitral-to-apical pressure gradient. Methods and Results —In 9 open-chest anesthetized dogs, micromanometers were placed near mitral tip region. From images, time delay (TD) between peak velocity at region was determined an index LV flow propagation. Acute ischemic failure induced coronary...
We wanted to explore whether change in LA (left atrium) size would influence function, or increase regurgitation the atrioventricular valves. 595 male elite football players and 47 non-athletic controls were included. End-systolic volume RA area end-diastolic LV RV measured by 2-dimensional (2D) echocardiography Pulsed colour Doppler used estimate tricuspid mitral regurgitations. 2D longitudinal strain of 50 with largest volumes compared smallest volumes. The some athletes large atria more...
Objectives To investigate the sex-specific prevalence of atrial fibrillation (AF), including subclinical AF found by screening in a general population aged 63–65 years. The cardiovascular risk factors and their association with will also be investigated. Design Cross-sectional analysis an observational, prospective, longitudinal, population-based cohort study. Setting General Akershus county, Norway. Participants Women men born 1950. We included 3706 5827 eligible individuals (63.6%); 48.8%...
Abstract Background Concentrations of cardiac troponin I (cTnI) and T (cTnT) are associated with clinical outcomes, but do not correlate closely in subjects recruited from the general population. Accordingly, we hypothesized that cTnI cTnT concentrations would be influenced by different cardiovascular (CV) non-CV risk factors reflect CV phenotypes. Methods We measured last generation assays 1236 women 1157 men no known disease participating prospective observational Akershus Cardiac...
Background No data exist on ambulatory blood pressure (ABP) in athletes. Objectives To identify ABP and examine recommended follow-up of high office (OBP) male professional football players secondary study indicators sympathetic activity. Methods Players with OBP (cases) from a previous screening 594 (n=28) were matched for age ethnicity optimal (controls). High was defined as mean ≥135/85 mm Hg during daytime ≥120/75 night-time. The replied to questions regarding OBP. night-time lack...
Anthracycline treatment may cause myocyte loss and expansion of the myocardial extracellular volume (ECV) fraction by oedema fibrosis. We tested hypotheses that adjuvant for early breast cancer with anthracycline epirubicin is dose dependently associated increased ECV total ECV, as well reduced cellular volume, these changes could be prevented concomitant angiotensin or beta-adrenergic blockade. PRevention cArdiac Dysfunction during Adjuvant therapy (PRADA) was a 2 × factorial,...
The aim of the Akershus Cardiac Examination (ACE) 1950 Study is to investigate development and progression cardiovascular cerebrovascular disease (CVD/CeVD) in an extensively characterized age cohort middle-aged subjects with longitudinal long-term follow-up.The ACE a prospective, population-based, age-cohort study all men women born County, Norway. involves comprehensive baseline examination, especially for CVD/CeVD, including advanced ultrasound imaging biobanking ("deep phenotyping"). We...
Abstract Aims Increased left ventricular mechanical dispersion by 2D speckle tracking echocardiography predicts arrhythmias in ischaemic heart disease and failure. However, little is known about the general population. We aimed to study population diseases associated with increased risk of cardiovascular disease. Methods results The present cross-sectional consists 2529 subjects born 1950 included Akershus Cardiac Examination (ACE) study. Global longitudinal strain (GLS) was assessed from 17...
Acute myocardial ischemia has been associated with abnormal filling patterns in the left ventricular (LV) apex. We hypothesized that this may part be due to postsystolic shortening of ischemic apical segments, which leads reversal early diastolic flow. Fourteen open-chest anesthetized dogs were instrumented micromanometers LV apex and atrium sonomicrometers anterior wall. Intraventricular by color Doppler wall motion strain echocardiography (SDE) assessed from an view. Measurements taken...