A5071593474- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pulmonary Hypertension Research and Treatments
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Issues in Pregnancy
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
University of Oslo
2016-2025
Oslo University Hospital
2016-2025
Center for Innovation
2024
Centre Hospitalier Universitaire de Liège
2014-2022
University of Liège
2022
Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant
2022
Hôpital de la Timone
2022
Méditerranée Infection Foundation
2022
Institut de Recherche pour le Développement
2022
Vestre Viken Hospital Trust
2020
Left ventricular (LV) pressure–strain loop area reflects regional myocardial work and metabolic demand, but the clinical use of this index is limited by need for invasive pressure. In study, we introduce a non-invasive method to measure LV area. pressure was estimated utilizing profile an empiric, normalized reference curve which adjusted according duration isovolumic ejection phases, as defined timing aortic mitral valve events echocardiography. Absolute systolic set equal arterial measured...
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Left ventricular (LV) dyssynchrony reduces myocardial efficiency because work performed by one segment is wasted stretching other segments. In the present study, we introduce a novel noninvasive clinical method that quantifies energy as ratio between consumed during segmental lengthening (wasted work) divided shortening. The (WWR) principle was studied in 6 anesthetized dogs with left bundle branch block (LBBB) and 28 patients cardiomyopathy, including 12 LBBB 10 cardiac resynchronization...
Published on behalf of the European Society Cardiology. All rights reserved. © The Author(s) 2020.
Acute coronary artery occlusion (ACO) occurs in ∼30% of patients with non-ST-segment elevation-acute syndrome (NSTE-ACS). We investigated the ability a regional non-invasive myocardial work index (MWI) to identify ACO. Segmental strain analysis was performed before angiography 126 NSTE-ACS. Left ventricular (LV) pressure estimated non-invasively using standard waveform fitted valvular events and scaled systolic blood pressure. MWI calculated as area LV pressure-strain loop. Empirical cut-off...
Background — Postsystolic shortening in ischemic myocardium has been proposed as a marker of tissue viability. Our objectives were to determine if postsystolic represents active fiber or passive recoil and may be quantified by strain Doppler echocardiography (SDE). Methods Results In 15 anesthetized dogs, we measured left ventricular (LV) pressure, myocardial long-axis strains SDE, segment lengths sonomicrometry before during LAD stenosis occlusion. Active contraction was defined elevated...
Background — Tissue Doppler imaging (TDI) is a potentially powerful method for diagnosing myocardial ischemia. This study was designed to investigate how velocity patterns in ischemic myocardium relates regional function, and determine whether timing of measurements relative ejection isovolumic phases may increase the diagnostic power TDI. Methods Results In 17 open-chest anesthetized dogs we measured pressures by micromanometers, longitudinal segment lengths sonomicrometry, velocities...
This article presents an update of the results achieved by modern surgery in congenital heart defects (CHDs) over past 40 years regarding survival and need for reoperations, especially focusing on from 2 decades.From 1971 to 2011, all 7038 patients <16 age undergoing surgical treatment CHD at Rikshospitalet (Oslo, Norway) were enrolled prospectively. diagnosis, date, type operations recorded, as was all-cause mortality until December 31, 2012. CHDs classified simple (3751/7038=53.2%),...
This paper considers some of the changes in practice that have occurred last 5 years. There been significant improvements parental involvement care. Not all based on evidence from research: has also affected by changing technology and pressure industry other groups. Among research-based were: an awareness confidentiality, individualised developmental care, increased use inhaled nitric oxide, therapeutic hypothermia, less postnatal steroids (although dosage used is not evidence-based),...
Abstract Background Echocardiography is widely used to evaluate left ventricular (LV) diastolic function in patients suspected of heart failure. For sinus rhythm, a combination several echocardiographic parameters can differentiate between normal and elevated LV filling pressure with good accuracy. However, there no established approach for the evaluation atrial fibrillation. The objective present study was determine if clinical may be Results In multicentre 148 fibrillation patients, were...
Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct improves survival, but its use has been confined to patients with ST-segment-elevation The purpose this study was assess the relationship between echocardiographic parameters left ventricular (LV) systolic function obtained before revascularization final in non-ST-segment-elevation infarction, as well ability these identify substantial...
AimsPatients with acute coronary occlusion may lack typical signs of myocardial infarction in the electrocardiogram. We tested ability different echocardiographic modalities to identify by quantifying dysfunction patients non-ST-elevation syndrome (NSTE-ACS).
In a majority of patients with left bundle-branch block (LBBB), there is abnormal leftward motion the interventricular septum during preejection phase. This was considered to be passive, caused by early rise in right ventricular (RV) pressure, and has therefore been excluded from most indices (LV) dyssynchrony. If active, however, reflects onset septal activation should included. We investigated if passive response pressure changes or active contraction.LBBB induced 8 anesthetized dogs...
Background— This study proposes 2 new echocardiographic indices with potential application in acute coronary artery occlusion to differentiate between viable and necrotic myocardium identify reperfusion. We investigated whether the ratio systolic lengthening combined late postsystolic shortening (L-S ratio) could myocardial compliance, calculated as divided by pressure rise, myocardium. Methods Results— In anesthetized dogs, we measured left ventricular (LV) long-axis strain Doppler...
Background— Acceleration of the mitral ring during isovolumic contraction has been proposed as a load-independent index global left ventricular (LV) contractility. This study investigates whether myocardial acceleration (IVA) reflects regional Methods and Results— In acutely instrumented, anesthetized dogs, we measured LV pressure, long-axis velocities, IVA by tissue Doppler imaging (TDI) sonomicrometry at different levels contractility preload ischemia (reduced flow in anterior descending...
During left bundle branch block (LBBB), electromechanical delay (EMD), defined as time from regional electrical activation (REA) to onset shortening, is prolonged in the late-activated ventricular lateral wall compared with septum. This leads greater mechanical relative dyssynchrony. The aim of this study was determine mechanism EMD. We investigated phenomenon an experimental LBBB dog model (n = 7), patients 9) biventricular pacing devices, vitro papillary muscle 6), and a mathematical...