A5046741879- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Neural dynamics and brain function
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Traumatic Brain Injury Research
- Health, Environment, Cognitive Aging
- Child and Adolescent Psychosocial and Emotional Development
- Social and Intergroup Psychology
- Tactile and Sensory Interactions
- Cultural Differences and Values
- Hallucinations in medical conditions
- Workaholism, burnout, and well-being
- Perfectionism, Procrastination, Anxiety Studies
Harvard University
2022-2025
Michigan State University
2017-2025
McLean Hospital
2022-2025
Western Michigan University
2024
Stryker (United States)
2024
Wayne State University
2024
The Ohio State University
2024
Northwestern University
2024
Humboldt-Universität zu Berlin
2024
Brigham Young University
2024
Abstract Background and Hypothesis Sequential saccade planning requires corollary discharge (CD) signals that provide information about the planned landing location of an eye movement. These CD may be altered among individuals with schizophrenia (SZ), providing a potential mechanism to explain passivity anomalous self-experiences broadly. In healthy controls (HC), key oculomotor network transmits from thalamus frontal fields (FEF) intraparietal sulcus (IPS) also remaps FEF IPS. Study Design...
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) project assesses a large sample of individuals at clinical high-risk for developing psychosis (CHR) and community controls. Subjects are enrolled in 43 sites across 5 continents. assessments include domains similar to those acquired previous CHR studies along with novel that collected longitudinally period 2 years. In parallel the data acquisition, multidisciplinary teams experts have been working formulate analysis strategy...
In this study, we examined possible gender differences in reasons for faculty attrition during the last 20 years at a small women's liberal arts college. The rate was calculated from archival data collected through old college directories. As earlier studies, higher women (31%) than men (18.5%). Reasons leaving were assessed an online survey completed by 45 out of 66 tenure-track or tenured professors who left (excluding retirees). Work–family conflict most frequently cited reason leaving,...
Schizophrenia has long been framed as a disorder of altered brain connectivity, with dysfunction in thalamocortical circuity potentially playing key role the development illness phenotype, including psychotic symptomatology and cognitive impairments. There is emerging evidence for functional structural hypoconnectivity between thalamus prefrontal cortex persons schizophrenia spectrum disorders, well hyperconnectivity sensory motor cortices. However, it unclear whether dysconnectivity general...
Corollary discharge (CD) signals are “copies” of motor sent to sensory regions that allow animals adjust consequences self-generated actions. Autism spectrum disorder (ASD) is characterized by and deficits, which may be underpinned altered CD signaling. We evaluated oculomotor using the blanking task, measures influence saccades on visual perception, in 30 children with ASD 35 typically developing (TD) children. Participants were instructed make a saccade target. Upon initiation, presaccadic...
Abstract Background and Hypothesis Corollary discharge (CD) signals are “copies” of motor sent to sensory areas predict the corresponding input. They a posited mechanism enabling one distinguish actions generated by oneself vs external forces. Consequently, altered CD is hypothesized for agency disturbances in psychosis. Previous studies have shown decreased influence on visual perception individuals with schizophrenia—particularly those more severe positive symptoms. We therefore that may...
Objectives Deficits in social cognition predict poor functional outcome severe mental illnesses such as schizophrenia and autism. However, research findings on bipolar disorder ( BD ) are sparse inconsistent. This study aimed to characterize a critical cognitive process—eye gaze perception—and examine its correlates inform psychopathological mechanisms. Methods Thirty participants with , 37 healthy controls HC ), 46 psychiatric SZ completed an eye‐contact perception task. They viewed faces...
Gaze perception is a basic building block of social cognition, which impaired in schizophrenia (SZ) and contributes to functional outcomes. Few studies, however, have investigated neural underpinnings gaze their relation cognition. We address this gap.
By predicting sensory consequences of actions, humans can distinguish self-generated inputs from those that are elicited externally. This is one mechanism by which we achieve a subjective sense agency over our actions. Corollary discharge (CD) signals—“copies” motor signals sent to areas—permit such predictions, and CD abnormalities hypothesized for the disruptions in schizophrenia characterize subset symptoms. Indeed, behavioral evidence altered CD, including oculomotor system, has been...
Individuals with schizophrenia may fail to appropriately use temporal context and apply past environmental regularities the interpretation of incoming sensory information. Here we visual system as a test bed for investigating how prior experience shapes perception in individuals schizophrenia. Specifically, aftereffects, illusory percepts resulting from exposure input, measure influence events on current processing. At neural level, aftereffects arise due attenuation responses neurons that...
<h3>Background</h3> Impaired corollary discharge (CD) signalling disrupts the ability to predict sensory consequences of one's own actions; impaired CD may be specific schizophrenia or it also a transdiagnostic mechanism psychosis. We sought assess whether disruptions in oculomotor are equally present and bipolar disorder (BD) with psychotic features, these putative relate anomalous self-experiences. <h3>Methods</h3> recruited patients BD as well healthy controls, complete double-step...
Rapid inhibition or modification of actions is a crucial cognitive ability, which impaired in persons with schizophrenia (SZP). Primate neurophysiology studies have identified network brain regions that subserves control over gaze. Here, we examine effective connectivity within this oculomotor SZP and healthy controls (HC). During fMRI, participants performed stop-signal task variant they were instructed to saccade visual target (no-step trials) unless second appeared (redirect trials); on...
Abstract Schizophrenia has long been framed as a disorder of altered brain connectivity, with dysfunction in thalamocortical circuity potentially playing key role the development illness phenotype, including psychotic symptomatology and cognitive impairments. There is emerging evidence for functional structural hypoconnectivity between thalamus prefrontal cortex persons schizophrenia spectrum disorders, well hyperconnectivity sensory motor cortices. However, it unclear whether...
Background: Gaze perception is a basic building block of social cognition, which impaired in schizophrenia and contributes to functional outcomes. Few studies, however, have investigated neural underpinnings gaze their relation cognition. We address this gap.Method: recruited 77 patients 71 healthy controls, who completed various social-cognition tasks. During fMRI, participants (62 schizophrenia, 54 controls) gaze-perception task, where they judged whether faces with varying angles were...
ABSTRACT Background Evidence suggests dysfunction of GABAergic interneurons in psychosis, and prior research has linked function with a tendency toward negative affective states. Magnetic resonance spectroscopy (MRS) studies measuring GABA have yielded inconsistent findings. We investigate concentrations young adults attenuated psychosis syndrome (APS) first episode (FEP), as well testing the hypothesis that affect is clinical phenotype associated reduced GABA. Materials MRS data were...