A5070994710- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and genetic disorders
- Neuropeptides and Animal Physiology
- Peripheral Neuropathies and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Coronary Interventions and Diagnostics
- Epilepsy research and treatment
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- S100 Proteins and Annexins
- Neurosurgical Procedures and Complications
- Diabetes Treatment and Management
- Voice and Speech Disorders
- Neurological Disease Mechanisms and Treatments
- Health disparities and outcomes
- Diet and metabolism studies
- Autoimmune Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological and metabolic disorders
- Peptidase Inhibition and Analysis
National Cerebral and Cardiovascular Center
2017-2025
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Kyoto University
2013-2023
National Museum of Ethnology
2021
Otsu Red Cross Hospital
2014-2018
Background RING finger protein 213 ( RNF213 ) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people. Recent evidence suggests its potential association with extracranial cardiovascular diseases, including pulmonary hypertension. We hypothesized that insidious abnormal cardiac functions are detected carriers cerebrovascular diseases. Methods Results investigated patients registered the National Cerebral Cardiovascular Center Genome...
Abstract This study aims to develop and validate prediction models for the number of all heatstroke cases, heatstrokes hospital admission death cases per city 12 h, using multiple weather information a population-based database patients in 16 Japanese cities (corresponding around 10,000,000 population size). In testing dataset, mean absolute percentage error generalized linear with wet bulb globe temperature as only predictor optimal models, respectively, are 43.0% 14.8% spikes 37.7% 10.6%...
Intracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy are more common East Asian populations than people of white European ancestry. We hypothesized that the ethnic difference is explained by Asian-specific NOTCH3 p.R75P mutation.
National-level data on trends in the prognosis of age-stratified patients with intracerebral hemorrhage (ICH) are lacking. This study aimed to assess time in-hospital mortality and functional outcomes ICH by sex age, explore factors associated changes trend.
The current approach to obesity care, which primarily focuses on weight loss, is often insufficient because of the challenges in maintaining long-term results. Therefore, novel, safe, and sustainable medications for are highly anticipated. Taxifolin, a natural bioactive flavonoid, was found exert pleiotropic protective effects against various diseases. Our experimental vivo vitro studies revealed that taxifolin administration contributes loss. Accordingly, we hypothesized oral intake...
Background Our previous preclinical study demonstrated that APOE4 ‐targeted replacement mice exhibit more severe cerebral hypoperfusion and cognitive impairment than APOE3 with carotid artery stenosis due to neurovascular dysfunction. Therefore, we clinically investigate whether contributes hemodynamic in subjects asymptomatic or occlusion. Methods Results A cross‐sectional observational was conducted between January 2017 March 2022. In a primary analysis, 91 (114 affected hemispheres)...
Objective To assess whether post-stroke epilepsy (PSE) is associated with neuroimaging findings of hemosiderin in a case–control study, and the addition markers improves risk stratification models PSE. Methods We performed post-hoc analysis PROgnosis POST-Stroke Epilepsy study enrolling PSE patients at National Cerebral Cardiovascular Center, Osaka, Japan, from November 2014 to September 2019. was diagnosed when one unprovoked seizure experienced >7 days after index stroke, as proposed by...
Vascular risk factors, such as type 2 diabetes mellitus (T2DM), are associated with the increased of Alzheimer's disease. One common T2DM medications, dipeptidyl peptidase (DPP)-4 inhibitors, have a minimum for hypoglycemia and recently been suggested to ameliorate β-amyloid pathology. However, conflicting results reported regarding effects DPP-4 inhibition on cognitive function tau Thus, we investigated whether inhibiting affects pathology cognition in mouse model tauopathy hyperglycemia....
Background: The development of numerous disease-modifying drugs for age-related dementia has been attempted based on the amyloid-β (Aβ) hypothesis without much success. Taxifolin (TAX), a natural bioactive flavonoid, shows pleiotropic neuroprotective effects with inhibition Aβ aggregation, production, and glycation, antiinflammatory effects, amelioration waste clearance system. We hypothesized that TAX intake is associated suppression cognitive deterioration. Objective: To investigate...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary cerebral small vessel disease (SVD), currently lacks disease-modifying treatments. Adrenomedullin (AM), a vasoactive peptide angiogenic, vasodilatory, anti-inflammatory, anti-oxidative properties, shows potential effects on neuro-glial-vascular unit. The AdrenoMedullin for CADASIL (AMCAD) study aims to assess efficacy safety AM in patients CADASIL. Overall,...
Improved outcomes in patients with subarachnoid hemorrhage (SAH) treated at high-volume centers have been reported. The authors sought to examine whether hospital case volume and comprehensive stroke center (CSC) capabilities affect clipping or coiling for SAH.
In-home monitoring systems have been used to detect cognitive decline in older adults by allowing continuous of routine activities. In this study, we investigated whether unobtrusive in-house power technologies could be predict impairment. A total 94 aged ≥65 years were enrolled study. Generalized linear mixed models with subject-specific random intercepts evaluate differences the usage time home appliances between people and without Three independent parameters representing activity...
To evaluate the prognostic impact of fragmented QRS (fQRS) on idiopathic dilated cardiomyopathy (DCM).We conducted a prospective observational study 290 consecutive patients with DCM (left ventricular ejection fraction ≤ 40%) and narrow who underwent cardiac magnetic resonance. We defined fQRS as presence various RSR' patterns in ≥2 contiguous leads representing anterior (V1-V5), inferior (II, III, aVF), or lateral (I, aVL, V6) myocardial segments. Multiple was Patients were divided into...
Importance Chronic hemodynamically significant aortic regurgitation (AR) is associated with excess risk of death, yet data for Asian patients are lacking, and whether can abide by Western guidelines as to when valve surgery should be performed unknown. Objective To assess AR presentation cutoffs left ventricular ejection fraction (LVEF), LV end-systolic dimension index (LVESDi), volume (LVESVi) that death in AR. Design, Setting, Participants This retrospective cohort study included...
The RNF213 p.R4810K variant is associated with moyamoya disease in East Asian individuals and increases the risk of developing intracranial major artery stenosis/occlusion (ICASO) that affects anterior circulation. Meanwhile, 0.5% to 2.5% asymptomatic also carry this variant. As such, additional factors are likely required develop ICASO carriers. Familial hypercholesterolemia (FH) a common genetic disorder Japan has significant premature coronary atherosclerosis; however, relationship...
Recent evidence indicates the efficacy of β-amyloid immunotherapy for treatment Alzheimer disease, highlighting need to promote removal from brain. Cilostazol, a selective type 3 phosphodiesterase inhibitor, promotes such clearance by facilitating intramural periarterial drainage.
Dementia-related missing and subsequent deaths are becoming serious problems with increases in people dementia. However, there no sufficient studies investigating the incidence rate, mortality their risk factors.An ecological study aggregated at Japanese prefectural level was conducted. persons cases 2018 were extracted from statistics of National Police Agency Japan. We variables about older adults' characteristics, care, safety as candidate considered to be relevant dementia-related...
The impact of glucose fluctuation on intracranial artery stenosis remains to be elucidated. This study aimed investigate the association between and stenosis. was a cross-sectional type 2 diabetes mellitus (T2DM) patients equipped with FreeStyle Libre Pro continuous monitoring system (Abbott Laboratories) February 2019 June 2020. Glucose evaluated according standard deviation (SD) blood glucose, coefficient variation (%CV), mean amplitude glycemic excursions (MAGE). Magnetic resonance...
Vulnerable plaque features including lipidic have been shown to affect fractional flow reserve (FFR). Given that formation and propagation of lipid is accompanied by endothelial dysfunction which impairs vascular tone, the degree burden may vasoreactivity during hyperemia, potentially leading reduced FFR. Our aim elucidate relationship extent with coronary physiological measure.
The International Atherosclerosis Society (IAS) has proposed "severe familial hypercholesterolemia" (FH) as a phenotype with the highest cardiovascular risk. However, whether this criteria could appropriately stratify high-risk Japanese patient FH remains unknown.This study sought to characterize atherosclerotic diseases in IAS-defined subjects severe FH.This analyzed 380 clinically diagnosed heterozygous without any history of diseases. Severe was defined untreated low-density lipoprotein...
Abstract Objectives Wandering behavior is one of the most troublesome behavioral disturbances in dementia. Inconsistent associations between physical function and wandering were reported, effect cognitive decline may be different according to walking ability. The purposes this study are investigate whether high ability a risk factor for interaction with older adults Methods This retrospective cohort included 3979 elderly association incidence during 5‐year follow‐up period examined using...
Postseizure functional decline is a concern in poststroke epilepsy (PSE). However, data on electroencephalogram (EEG) markers associated with are scarce. Thus, we investigated whether periodic discharges (PDs) and their specific characteristics patients PSE.In this observational study, admitted seizures of PSE who had scalp EEGs were included. The association between the presence or absence PDs postseizure short-term lasting 7 days after admission was investigated. In PD, EEG explored for...