A5033383477- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Neurological Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Neurological Complications and Syndromes
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Face and Expression Recognition
- Venous Thromboembolism Diagnosis and Management
- Image Processing Techniques and Applications
- Spinal Hematomas and Complications
- Image Retrieval and Classification Techniques
- Medical Imaging and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal and Vascular Pathologies
- Atrial Fibrillation Management and Outcomes
Kyushu University
2016-2025
Koga Hospital
2007-2025
Kyushu University Hospital
2021
Kobe City Medical Center General Hospital
2015-2019
Clinical Research Institute
2018
Nara Medical University
2018
Kyorin University
2018
Showa University Hospital
2018
Iwate Medical University
2018
National Cerebral and Cardiovascular Center
2018
Platelet derived growth factor (PDGF)-B plays a neuroprotective role in brain damages, including ischemic stroke. It has been suggested recently that PDGF receptor β (PDGFRβ) expressed pericytes as well neurons and astrocytes may mediate the of PDGF-B. The aims this study were to elucidate roles PDGFRβ signaling after In rat middle cerebral artery occlusion (MCAO) model, expression was induced specifically peri-infarct areas its level gradually increased. PDGF-B marked phosphorylation Akt...
<h3>Objectives</h3> This cross-sectional survey explored the characteristics and outcomes of direct oral anticoagulant (DOAC)–associated nontraumatic intracerebral hemorrhages (ICHs) by analyzing a large nationwide Japanese discharge database. <h3>Methods</h3> We analyzed data from 2,245 patients who experienced ICHs while taking anticoagulants (DOAC: 227; warfarin: 2,018) were urgently hospitalized at 621 institutions in Japan between April 2010 March 2015. compared DOAC- warfarin-treated...
Pericytes are mural cells abundantly present in cerebral microvessels and play important roles, including the formation maintenance of blood-brain barrier. Nox4 is a major source reactive oxygen species cardiovascular modulate cellular functions, particularly under pathological conditions. In study, we found that expression was markedly induced microvascular cells, pericytes, peri-infarct areas after middle artery occlusion stroke models mice. The upregulation greater permanent model...
Purpose To evaluate and compare the performance of acceleration-selective arterial spin labeling (AccASL) magnetic resonance (MR) angiography in visualization cerebral arteries collateral vessels patients with Moyamoya disease that time-of-flight (TOF) MR angiography, digital subtraction (DSA) as reference standard. Materials Methods Thirty-six hemispheres from 22 underwent TOF AccASL DSA. Qualitative evaluations included imaging terminal internal carotid artery (ICA), distal middle (MCAs),...
Objective We sought to examine whether the effect of treatment modality and drugs for cerebral vasospasm on clinical outcomes differs between elderly non-elderly subarachnoid hemorrhage (SAH) patients in Japan. Methods analyzed J-ASPECT Study Diagnosis Procedure Combination database (n = 17,343) that underwent clipping or coiling 2010 2014 579 hospitals. stratified into two groups according their age (elderly [≥75 years old], n 3,885; non-elderly, 13,458). anti-vasospasm agents (fasudil...
We have previously shown that Na(+)/H(+) exchanger isoform 1 (NHE1) plays an important role in Ca(2+) signaling and cell proliferation human central nervous system (CNS) pericytes. The aims of the present study were to elucidate how NHE1-induced during acidosis is transformed into cellular responses CNS pericytes.Human pericytes cultured, activation cAMP responsive element-binding protein (CREB) was evaluated by Western blotting analysis, immunofluorescence, luciferase assays. In pericytes,...
Background The efficacy of combined stent retriever (SR) and aspiration catheter (AC; technique: CBT) use for acute ischemic stroke (AIS) is unclear. We investigated the safety single-unit CBT (SCBT)—retrieving thrombus as a single unit with SR AC into guide catheter—compared either or contact (CA). Methods analysed 763 consecutive patients who underwent mechanical thrombectomy AIS between January 2013 2020, at six comprehensive centers. Patients were divided SCBT device (SR/CA) groups....
<h3>BACKGROUND AND PURPOSE:</h3> An accurate assessment of the hemodynamics an intracranial dural AVF is necessary for treatment planning. We aimed to investigate utility 4D-MRA based on superselective pseudocontinuous arterial spin-labeling with CENTRA-keyhole and view-sharing (4D-S-PACK) vessel-selective visualization AVFs. <h3>MATERIALS METHODS:</h3> retrospectively analyzed images 21 patients (12 men 9 women; mean age, 62.2 [SD,19.2] years) AVFs, each whom was imaged DSA, 4D-S-PACK,...
Abstract Objective We evaluated the effect of CHA 2 DS ‐VASc score and prior use oral anticoagulants (OACs) on endovascular treatment (EVT) in patients with acute ischemic stroke atrial fibrillation (AF). Methods Patients AF who received EVT 353 centers Japan (2018–2020) were included. The outcomes symptomatic intracerebral hemorrhage (sICH), in‐hospital mortality, functional independence, successful complete reperfusion. effects score, its components, OACs assessed via a multiple logistic...
Improved outcomes in patients with subarachnoid hemorrhage (SAH) treated at high-volume centers have been reported. The authors sought to examine whether hospital case volume and comprehensive stroke center (CSC) capabilities affect clipping or coiling for SAH.
To examine the national, 6-year trends in in-hospital clinical outcomes of patients with subarachnoid haemorrhage (SAH) who underwent clipping or coiling and prognostic influence temporal Comprehensive Stroke Center (CSC) capabilities on patient Japan.