A5083744025- Intracranial Aneurysms: Treatment and Complications
- Lymphatic System and Diseases
- Heavy Metal Exposure and Toxicity
- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Neurosurgical Procedures and Complications
- Sympathectomy and Hyperhidrosis Treatments
- Tracheal and airway disorders
- Lymphatic Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Meningioma and schwannoma management
- Diagnosis and Treatment of Venous Diseases
- Head and Neck Surgical Oncology
- Vascular Malformations and Hemangiomas
- Trace Elements in Health
- Vascular Malformations Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Acute Ischemic Stroke Management
- Air Quality and Health Impacts
- Intracerebral and Subarachnoid Hemorrhage Research
- Indoor Air Quality and Microbial Exposure
- Carcinogens and Genotoxicity Assessment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Neurofibromatosis and Schwannoma Cases
Daido University
2024-2025
National Hospital Organization
2006-2024
Nagoya Medical Center
2011-2024
Japanese Red Cross Nagoya Daini Hospital
2013-2024
Japanese Foundation For Cancer Research
2023-2024
St. Marianna University School of Medicine
2015-2024
Tsurugi Hospital
2018-2024
Nagoya University
1995-2023
University of Tokyo Hospital
2013-2018
National Center for Global Health and Medicine
2018
Background and Purpose —Increased activation of excitatory amino acid (EAA) receptors is considered a major cause neuronal damage. Possible sources mechanisms ischemia-induced EAA release were investigated pharmacologically with microdialysis probes placed bilaterally in rat striatum. Methods —Forebrain ischemia was induced by bilateral carotid artery occlusion controlled hypotension halothane-anesthetized rats. During 30 minutes ischemia, microdialysate concentrations glutamate aspartate...
Among various surgical treatments, lymphaticovenular anastomosis (LVA), which bypasses congested lymph into venous circulation, is the least invasive treatment. However, it usually entails skin incisions of around 3 cm, and operation time 4 hours. With multiple supermicrosurgeons under guidance indocyanine green lymphography, LVAs can be simultaneously performed local anesthesia within approximately 2 hours via small with length less than 1 allowing minimally lymphatic supermicrosurgery...
Background: The authors investigated the relationship between findings from indocyanine green lymphography and condition of lymphatics according to Normal, Ectasis, Contraction, Sclerosis Type classifications observed in each area during surgery. Methods: examined 43 limbs 25 patients who had undergone lymphaticovenous anastomosis April July 2012 at Department Plastic Reconstructive Surgery, University Tokyo Hospital. After injection green, linear, splash, stardust, diffuse patterns were...
Lymphatic supermicrosurgery, lymphaticovenular anastomosis (LVA), is becoming a treatment option for progressive lymphedema with its effectiveness and minimal invasiveness. It important to detect anastomose large functional lymphatic vessels LVA surgery. This study aimed evaluate usefulness of near-infrared illumination system-integrated microscope supermicrosurgery.We performed on 12 lower extremity (LEL) patients or without intraoperative microscopic indocyanine green (ICG) lymphography...
Lymph transportation capacity is a critical function maintaining fluid circulation. After pelvic cancer treatments, lymph obstruction at the region leads to abnormal circulation, resulting in pump dysfunction. Besides important for lymphedema evaluation. We assessed and analyzed of secondary lower extremity patients using indocyanine green (ICG) lymphography according corresponding severity stage. Indocyanine velocity transit time could evaluate function; ICG decreases increases as stage...
Lymphaticovenular anastomosis (LVA) is a useful treatment for compression-refractory lymphedema with its effectiveness and minimal invasiveness. However, LVA requires supermicrosurgery, where lymphatic vessels diameter of 0.5 mm or smaller are anastomosed using 11-0 12-0 suture. To make easier safer, we adopted modified side-to-end (S-E) in surgery.We performed S-E LVAs 14 limbs female patients lower extremity (LEL). In LVA, lateral windows length 1.0 longer were created on vessel vein,...
Lymphatic vessel diameter and lymph flow are important for accurate anastomosis effective lymph-to-venous in lymphaticovenular anastomosis. The authors developed a reliable method, the superioredge-of-the-knee incision detecting making best use of high-flow lymphatic vessels distal medial thigh between deep superficial fascia, where movement knee, combined with compression these fascial layers, theoretically results upward propulsion fluid.Intraoperative detection large venous reflux...
The effect of human adrenomedullin on cerebral circulation was investigated in dogs vivo and vitro. Bolus administration or its homologous peptides, calcitonin gene-related peptide (CGRP) amylin, into the vertebral artery induced a dose-dependent increase blood flow. potencies CGRP were similar approximately 100 times more than that amylin. effects inhibited by 8-37 , an antagonist CGRP. In contrast to substance P, did not induce flow after prior Pretreatment with either N G...
Background Supermicrosurgical lymphaticovenular anastomosis (LVA) is becoming a treatment option for progressive lymphedema. Various types of LVA such as end-to-end, end-to-side, side-to-end, and side-to-side are performed to improve the efficacy. Methods We applied sequential surgery, in which 2 lymphatic vessels were anastomosed 1 venule using side-to-end anastomoses. Six lower extremity lymphedema (LEL) patients who underwent included this study. Feasibility, patency, effect method...
Abstract Objective To evaluate the midterm surgical outcomes and factors associated with extent of resection (EOR), postoperative visual improvement, risk for cerebrospinal fluid (CSF) leaks in cases endoscopic endonasal approach (EEA) tuberculum sellae meningiomas (TSMs), including utilizing malleable forceps. Design Retrospective clinical study. Setting Single-center tertiary referral hospital. Participants Twenty-two patients who underwent EEA TSMs between November 2013 April 2024. Main...
Taurine has multiple functions in the central nervous system (CNS), serving as an osmoregulator, antioxidant, inhibitory neuromodulator, and regulator of intracellular Ca2+ flux. Since role taurine traumatic spinal cord injury (SCI) is not fully understood, present study was conducted with C57 black/6 mice (18–20 g) who underwent severe SCI at Th-8 level using a weight compression device. injected intraperitoneally doses 25, 80, 250, 800 mg/kg within 30 min after SCI. Controls were saline....
In severe lymphedema, indocyanine green lymphography cannot be used to map lymphatic channels before lymphaticovenular anastomosis (LVA) because linear lymphatics detected in a severely affected leg. Here, we describe new method, which refer as predictive mapping, predict the location of for unilateral thereby improving surgical accuracy and efficiency. The approach consists marking anatomical landmarks joining selected with fixed lines. distance from these lines mapped by unaffected leg is...
Surgical treatment of lower extremity lymphedema (LEL) remains challenging. Application the superior-edge-of-the-knee incision method for lymphaticovenular anastomosis (LVA) is reported to have a strong therapeutic effect in patients with LEL because lymph-to-venous flow at enhanced by knee joint movement during normal walking. We investigated whether single LVA created this adequate early LEL.The study involved 10 characterized stage 2 or 3 leg dermal backflow and treated thigh via method....
To investigate the importance of cadmium (Cd) exposure condition in evaluation toxic effect on renal function and bone metabolism, six groups Male Wistar rats were given Cd at respective daily doses 2, 5, 10, 20, 30 60 mgCd/kg (as CdCl2) via a gastric tube for 6 consecutive days week weeks. In low dose (2, 5 10 mgCd/kg), relatively more accumulated kidney without liver damage than liver. high (20, other hand, kidney. The intake from intestinal tract each experimental group was deduced to be...
✓ The authors report two patients with benign fibroosseous lesions involving the center of skull base: a 15-year-old boy repetitive meningitis and pneumocephalus 11-year-old nasal obstruction headache. clinical diagnoses were ossifying fibroma aneurysmal bone cyst, respectively. Lesions in both extended to cavity, sphenoid posterior ethmoid sinuses, base, where planum sphenoidale, sella turcica, upper two-thirds clivus, medial portion middle cranial base involved. totally removed using an...
The surgical techniques for treatment of chronic subdural hematoma (CSDH), a common neurosurgical condition, have been discussed in lot clinical literature. However, the recurrence proportion after CSDH surgery remains high, ranging from 10 to 20%. standard procedure involves craniostomy evacuate hematoma, but irrigating cavity during is debatable. authors hypothesized that choice irrigation fluid might be key factor affecting outcomes surgery. This multicenter randomized controlled trial...
In this study cadmium concentrations in several organs of more than 100 cadavers were measured order to estimate the total body burden by age. Six hundred urine samples from inhabitants Tokyo various age groups collected measure observe if urinary concentration reflects burden. The average renal group 40-49 years reached about 200μg/g (20mg net weight kidneys). However, individual variation was very great. calculated be 45mg 30-59 years. general, and increased with age, leveling off at 60...
Summary: Indocyanine green (ICG) lymphography is a useful imaging modality for evaluation of lymphedema and detection lymphatic vessels. It also allows us to ensure patency the anastomosed vessels intraoperatively. However, strong light from operating microscope usually disturbs ICG fluorescence imaging. Only some built-in camera systems with specific microscopes make real-time possible in lymphaticovenular anastomosis (LVA). We applied new high-resolution videolymphography system, which...