A5052357228- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- CAR-T cell therapy research
- Brain Metastases and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Phagocytosis and Immune Regulation
- Herpesvirus Infections and Treatments
- Immune cells in cancer
- Thermodynamic and Structural Properties of Metals and Alloys
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cell Adhesion Molecules Research
- Facial Nerve Paralysis Treatment and Research
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Fibroblast Growth Factor Research
- Coronary Interventions and Diagnostics
- Ear and Head Tumors
- Boron Compounds in Chemistry
- Silk-based biomaterials and applications
- Chemokine receptors and signaling
- RNA Interference and Gene Delivery
- Medical and Biological Sciences
The University of Tokyo
2011-2025
RIKEN Center for Brain Science
2023
University of Tokyo Hospital
2009-2022
Fukuoka University Hospital
2022
Creative Commons
2021
National Center for Global Health and Medicine
2016-2018
Massachusetts General Hospital
2009
Saitama International Medical Center
2009
Heinrich Heine University Düsseldorf
2009
La Trobe University
1980
This investigator-initiated, phase 2, single-arm trial primarily assessed the efficacy of G47∆, a triple-mutated, third-generation oncolytic herpes simplex virus type 1, in 19 adult patients with residual or recurrent, supratentorial glioblastoma after radiation therapy and temozolomide (UMIN-CTR Clinical Trial Registry UMIN000015995). G47Δ was administered intratumorally repeatedly for up to six doses. The primary endpoint 1-yr survival rate G47∆ initiation 84.2% (95% confidence interval,...
Abstract Here, we report the results of a phase I/II, single-arm study (UMIN-CTR Clinical Trial Registry UMIN000002661) assessing safety (primary endpoint) G47∆, triple-mutated oncolytic herpes simplex virus type 1, in Japanese adults with recurrent/progressive glioblastoma despite radiation and temozolomide therapies. G47Δ was administered intratumorally at 3 × 10 8 pfu (low dose) or 1 9 (set dose), twice to identical coordinates within 5–14 days. Thirteen patients completed treatment dose,...
The management of vestibular schwannoma (VS) remains controversial. One commonly cited advantage microsurgery over other treatment modalities is that tumor removal provides the greatest chance long-term cure. However, there are very few publications with follow-up to support this assertion. purpose current study report risk recurrence among a large historical cohort patients who underwent microsurgical resection.
Tribbles pseudokinase 1 (
Endothelial cells (ECs) display distinct structural and functional characteristics depending on the tissue developmental stage; however, development of tissue-specific ECs remains poorly understood. Here, we describe hepatic sinusoids in mice based expression hyaluronan receptors Stab2 Lyve-1. Flk-1+ around liver bud begin to express at embryonic day (E) 9.5, before formation vascular lumen. Hepatic sinusoidal endothelial (HSECs) Lyve-1 E10.5, both markers continue be expressed HSECs...
Intracranial aneurysms (IAs) are a high-risk factor for life-threatening subarachnoid hemorrhage. Their etiology, however, remains mostly unknown at present. We conducted screening sporadic somatic mutations in 65 IA tissues (54 saccular and 11 fusiform aneurysms) paired blood samples by whole-exome targeted deep sequencing. identified multiple signaling genes examined their impact on downstream pathways gene expression vitro an arterial dilatation model mice vivo. 16 that were mutated least...
Abstract BACKGROUND: Stereotactic radiosurgery (SRS) is among the few therapeutic options for glioblastoma that recurs after standard radiation and chemotherapy, but its efficacy has been limited. METHODS: Since November 2007, authors have modified clinical target volume by adding a 0.5‐ to 1‐cm margin gadolinium‐enhanced area (extended field SRS), in contrast conventional SRS using no set volume. A total of 35 recurred lesions 9 patients were treated with between December 1990 January 14...
Giant fusiform and dolichoectatic aneurysms of the basilar trunk vertebrobasilar junction (BTVBJ-GFDA) are extremely difficult to treat.To evaluate factors influencing survival outcome BTVBJ-GFDA by performing a retrospective multicenter cohort study.A total 32 patients with were included in this study. Clinicopathological characteristics, treatment measures, outcomes collected from medical records imaging studies. Autopsy histological findings aneurysm adjacent brain tissue also obtained 9...
Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic neoplasm of the brain. Some PXAs are accompanied by anaplastic features and difficult to manage because frequent recurrences that lead early death. No previous reports have demonstrated consistent efficacy adjuvant radiotherapy or chemotherapy for this disease. We report case PXA with treated stereotactic irradiation (STI) resulted in long-term control repeatedly recurring nodules throughout neuraxis. A 47-year-old woman presented an...
Restoration of cranial nerve functions during acoustic neuroma (AN) surgery is crucial for good outcome. The effects minimizing the injury period and maximizing recuperation were investigated in 89 patients who consecutively underwent retrosigmoid unilateral AN surgery.Cochlear facial evaluated by use continuous auditory evoked dorsal cochlear nucleus action potential monitoring root exit zone-elicited compound muscle monitoring, respectively. Factors affecting preservation function at same...
We treated a 54-year-old Japanese female with recurrent radiation-induced osteosarcoma arising from left occipital skull, by reactor-based boron neutron capture therapy (BNCT). Her tumor grew rapidly subcutaneous and epidural extension. She eventually could not walk because of cerebellar ataxia. The was inoperable radioresistant. BNCT showed marked initial therapeutic effect: the subcutaneous/epidural reduced without radiation damage scalp except hair loss patient again only 3 weeks after...
Abstract The temperature dependence of the Knight shift in liquid metals at constant volume is investigated theoretically on basis nearly-free-electron model. A comparison made theoretical value with experimental determined here for sodium. ratio coefficients and solid state also discussed.
The prognosis of oral squamous cell carcinoma (OSCC) largely depends on the control lymph node metastases. We evaluate therapeutic efficacy G47Δ, a third-generation oncolytic herpes simplex virus type 1 (HSV-1), in mouse tongue cancer models. Intratumoral injection with G47Δ prolonged survival all orthotopic models investigated. In both athymic and immunocompetent models, injected into swiftly traffics to draining cervical nodes suppresses KLN205-MUC1 model, which metastatic cascade that...
✓ The authors present the clinical, radiological, and pathological features of a malignant intracerebral nerve sheath tumor that occurred in right parietooccipital lobe 4-year-old girl. Computerized tomography scanning magnetic resonance imaging demonstrated 5 × 4—cm multiloculated mass with considerable enhancement irregularly shaped septa clearly calcified areas within mass. Among five cases reported literature, this patient is youngest represents first case which there radiological...
Fibroblast growth factors (FGFs) transduce signals through FGF receptors (FGFRs) and have pleiotropic functions. Besides signal-transducing FGFRs, cysteine-rich receptor (Cfr; Glg1) is also known to bind some FGFs, although its physiological functions remain unknown. In this study, we generated Cfr-deficient mice found that of them die perinatally, show retardation, tail malformation cleft palate. These phenotypes are strikingly similar those Fgf18-deficient mice, revealed interaction...
Tissue-resident macrophages and bone marrow (BM)-derived monocytes play a crucial role in the maintenance of tissue homeostasis; however, their contribution to recovery from acute injury is not fully understood. To address this issue, we generated an murine liver model using hepatocyte-specific Cflar-deficient (CflarHep-low) mice. Cellular FLICE-inhibitory protein expression was down-regulated hepatocytes, which thereby increased susceptibility hepatocytes death receptor–induced apoptosis....
We aimed to assess the clinical efficacy of glutaraldehyde-fixed human umbilical vein endothelial cell (HUVEC) vaccine for treatment patients with recurrent glioblastoma. Patients a HUVEC group received intradermal injections 5 × 10(7) weekly during first month, and every 2 weeks from second until progression disease was observed. Salvage consisted multimodal chemotherapy, radiation, including gamma-knife therapy, and/or repeated surgery, when feasible. Hazard ratios death were calculated...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease known for its dense tumor stroma. Focal adhesion kinase inhibitor (FAKi), non-receptor type tyrosine inhibitor, reduces the G47Δ, third-generation oncolytic herpes simplex virus 1, destroys cells selectively and induces antitumor immune responses. This study evaluates efficacy of FAKi G47Δ in PDAC models combination with or without checkpoint inhibitors. was effective human cell lines vitro subcutaneous as well orthotopic models....