A5039872054- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Ocular Diseases and Behçet’s Syndrome
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Veterinary Pharmacology and Anesthesia
- Cyclopropane Reaction Mechanisms
- Intraocular Surgery and Lenses
- Neural dynamics and brain function
- Pancreatic function and diabetes
- Visual perception and processing mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Mesenchymal stem cell research
- Veterinary Equine Medical Research
- Synthetic Organic Chemistry Methods
- Veterinary Oncology Research
- Cancer Cells and Metastasis
- Diet, Metabolism, and Disease
- Pharmacological Receptor Mechanisms and Effects
- Hemoglobin structure and function
- Pain Mechanisms and Treatments
- Lipid metabolism and biosynthesis
- Corneal surgery and disorders
- Adipose Tissue and Metabolism
Okayama University of Science
2018-2022
Yamaguchi University
2012-2018
Muroran Institute of Technology
2016
Veterinary Medical Center
2015
Tottori University
2014
Rakuno Gakuen University
2005-2013
Doshisha University
2008-2011
Triangle
2010
Food Research Institute
1995-2009
Osaka University
2008
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Chiral Ruthenium Bis(oxazolinyl)pyridine Catalyst. Efficient Asymmetric Cyclopropanation of Olefins with DiazoacetatesHisao Nishiyama, Yoshiki Itoh, Hideki Matsumoto, Soon-Bong Park, and Kenji ItohCite this: J. Am. Chem. Soc. 1994, 116, 5, 2223–2224Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://doi.org/10.1021/ja00084a104RIGHTS & PERMISSIONSArticle...
Abstract A chiral ruthenium(II)–bis(2-oxazolin-2-yl)pyridine catalyst prepared in situ from optically active bis(2-oxazolin-2-yl)pyridine (Pybox-ip) (2) and [RuCl2(p-cymene)]2 (1) exhibited efficient activity for the asymmetric cyclopropanation (ACP) of styrene several diazoacetates to give corresponding trans- cis-2-phenylcyclopropane-1-carboxylates (3 4) good yields (66—87%). mixture 1 2 an atmosphere ethylene produced trans-RuCl2(Pybox-ip)(ethylene) complex (5), which also proved be a...
ADVERTISEMENT RETURN TO ISSUELetterNEXTDiscovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)Hiroshi Kawamoto, Satoshi Ozaki, Yoshiki Itoh, Mitsuru Miyaji, Sachie Arai, Hiroshi Nakashima, Tetsuya Kato, Hisashi Ohta, Yoshikazu IwasawaView Author Information Banyu Tsukuba Research Institute in collaboration with Merck Laboratories,...
Gadopentetate dimeglumine as an alternative contrast material for use in angiography.Y Kinno, K Odagiri, Andoh, Y Itoh and TaraoAudio Available | Share
A per-O-methylated β-cyclodextrin dimer, Py2CD, was conveniently prepared via two steps: the Williamson reaction of 3,5-bis(bromomethyl)pyridine and (β-CD) yielding 2A,2′A-O-[3,5-pyridinediylbis(methylene)bis-β-cyclodextrin (bisCD) followed by O-methylation all hydroxy groups bisCD. Py2CD formed a very stable 1:1 complex (Fe(III)PCD) with [5,10,15,20-tetrakis(p-sulfonatophenyl)porphinato]iron(III) (FeIIITPPS) in aqueous solution. Fe(III)PCD reduced Na2S2O4 to afford FeIITPPS/Py2CD...
Abstract The loss of skeletal muscle mass is a major cause falls and fractures in the elderly, leading to compromised independence decrease quality life. However, only few therapeutic interventions marginal clinical benefits patients with this condition are currently available. Therefore, demand further understand pathology atrophy establish treatment modality for significant. p38α mitogen-activated protein kinase (p38α MAPK) ubiquitous signaling molecule that implicated various cellular...
Objective Investigation was conducted to understand the mechanism of action diacylglycerol acyltransferase 1 (DGAT1) using small molecules DGAT1 inhibitors, compounds K and L . Design Methods Biochemical stable‐label tracer approaches were applied interrogate functional activities on TG synthesis changes carbon flow. Energy homeostasis gut peptide release upon inhibition in mouse dog models. Results Compounds , dose‐dependently inhibits post‐prandial excursion Weight loss studies WT Dgat1...
This study compared the effects of postoperative pain and inflammation reaction after preventive laparoscopic-assisted gastropexy (LAG) incisional (IG) in 10 clinically normal Beagles. Surgical time, incision length, visual analog scale (VAS) score, University Melbourne Pain Scale (UMPS) plasma C-reactive protein (CRP), cortisol (COR), serum interleukin-6 (IL-6) levels were evaluated. The VAS UMPS scores COR IL-6 recorded at 0.5, 1, 2, 4, 8, 12, 18 24 hr surgery. CRP level was 48 showed no...
A mixture of [{RuIICl2(p-cymene)}2]1 and 2,6-bis(4-isopropyloxazolinyl)pyridine (pyboxip)2 was treated with trimethylsilyldiazomethane to give the trimethylsilylcarbene complex trans-[RuIICl2(pyboxip)(CHSiMe3)]3 at 0–15 °C in 94% yield azine trans-[RuIICl2(pyboxip)(Me3SiCHN–NCHSiMe3)] 25–35 73% yield; catalytic activity 3 examined for dimerization asymmetric cyclopropanation ethyl diazoacetate.
Abstract The present study represents the first four‐digit allele genotyping of HLA‐A and ‐B in Japanese Behcet's disease (BD) patients controls using a new method (named PCR‐SSOP‐Luminex method) to determine association certain or alleles with BD. Peripheral blood lymphocytes were collected from 180 BD 170 healthy controls. genotype frequency HLA‐B*5101 was significantly increased (61.7%) as compared (15.9%) ( Pc = 1 × 10 −16 , OR 8.5). When we recalculated phenotype frequencies after...
Three types of per-O-methylated β-cyclodextrin dimers, Im2CD, Im3NHCD and Py3NHCD, were prepared as globin models. Im2CD was synthesized by the condensation reaction mono(2A-amino)-per-O-methylated with 3-(1H-imidazol-1-yl)pentanedioic acid. Py3NHCD obtained through SN2 reactions mono(2A,3A-epoxy)-per-O-methylated 3-(1H-imidazol-1-yl)pentane-1,5-diamine 3,5-bis(aminomethyl)pyridine, respectively. These cyclodextrin dimers formed 1 : supramolecular inclusion complexes...
The aim of this research was to evaluate the changes in response pattern-stimulated visual evoked potential (pVEP) with different pattern size, and demonstrate acuity from minimum angle. pVEP recorded both eyes six healthy beagles. Prior recording, dogs were sedated, a traction fiber used prevent eye rolling down. stimulator set 30 cm subject's eye. Pattern reversal frequency stimulating monitor 3 rev/sec, size at seven levels; 14-364 arc-min (1.2-31.4 mm). Amplitude P100 component...
Receptor binding and antagonist properties of an endothelin (ET) receptor antagonist, TAK-044 ¿cyclo[D-alpha-aspartyl-3-[(4-phenylpiperazin-1-yl) carbonyl]-L-alanyl-L-alpha-aspartylD-2-(2-thienyl) glycyl-L-leucyl-D-tryptophyl]disodium salt¿, were investigated using recombinant human ETA ETB receptors expressed in Chinese hamster ovary cells. The membranous was shown to be heterogeneous ET-3 affinity (Hill coefficient = 0.54, Kd1 390 pM Kd2 8.1 nM). This heterogeneity disappeared upon the...
Electroretinography (ERG) is an effective method for the diagnosis of retinal disease. In dog, dependable ERG recording difficult without use expensive device like a Ganzfeld full-field stimulator. The International Society Clinical Electrophysiology Vision has defined standard flash stimulus condition (SF) and evaluation retina using b/a ratio in humans. dogs, not been reported, whereas intensity SF defined. this study, we performed convenient contact lens electrode with built-in light...
Objective To investigate disease in the fellow eye, and consider relation to rhegmatogenous retinal detachment (RRD) Shih-Tzus. Animals studied The eyes of 49 Shih-Tzus (27 male, 22 female; median age: 6.8 years) with unilateral RRD diagnosed by funduscopy or ultrasonography at Rakuno Gakuen University Teaching Animal Hospital were assessed this study. Procedures Ophthalmic examinations (including menace response, pupillary light reflex, slit-lamp biomicroscopy, funduscopy) performed...
The purpose of this study was to investigate the effects sevoflurane concentration on canine visual evoked potentials with pattern stimulation (P-VEPs). Six clinically normal laboratory-beagle dogs were used. minimum alveolar (MAC) detected from all subjects by tail clamp method. refractive power right eyes corrected -2 diopters after skiascopy. For P-VEP recording, recording and reference electrode positioned at inion nasion, respectively, earth inner surface. To grasp state CNS suppression...
The majority of cases chemotherapy for hepatocellular carcinoma (HCC) are not effective in human or veterinary medicine due to resistance against anticancer agents. In medicine, stem cells (HCSCs) were recently identified as cytokeratin 19 (CK19)-, cluster differentiation (CD)-44-, and CD133-positive. However, there few previous reports regarding canine HCSC (cHCSC). Additionally, the best our knowledge, chemoresistance agents these cHCSCs has been investigated. present study staining was...
The purpose of this study was to investigate the effects refractive error on canine visual evoked potentials with pattern stimulation (P-VEP). Six normal beagle dogs were used. power recorded eyes measured by skiascopy. corrected -4 diopters (D) +2 D using contact lens. P-VEP at each power. stimulus size and distance 50.3 arc-min 50 cm. P100 appeared almost 100 msec -2 (at which monitor in focus). There significant prolongation implicit time -4, -3, 0 +1 compared D, respectively. We...