A5018962292- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Vitamin D Research Studies
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Radical Photochemical Reactions
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Blood Pressure and Hypertension Studies
- Catalytic C–H Functionalization Methods
- Pharmacological Effects and Toxicity Studies
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Function and Risk Factors
- Muscle and Compartmental Disorders
- Genetic and Kidney Cyst Diseases
- Obstructive Sleep Apnea Research
- Vascular Procedures and Complications
- Iron Metabolism and Disorders
- Gout, Hyperuricemia, Uric Acid
- Sulfur-Based Synthesis Techniques
- RNA Interference and Gene Delivery
- Heart Failure Treatment and Management
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
Nagoya University
2017-2024
University of Tsukuba
2024
Fujita Health University
2017-2022
Japanese Red Cross Nagoya Daini Hospital
2016-2019
Komaki City Hospital
2019
ORCID
2019
Japanese Society of Nephrology
2019
Kobe University
2015
Toho University
2011
Meijo University
1997-2004
The rapid transformation of pharmaceuticals and agrochemicals enables access to unexplored chemical space thus has accelerated the discovery novel bioactive molecules. Because arylacetic acids are regarded as key structures in compounds, new transformations these could contribute drug/agrochemical biology. This work reports carbon-nitrogen carbon-oxygen bond formation through photoredox-catalyzed decarboxylation acids. reaction shows good functional group compatibility without pre-activation...
Novel coronavirus disease 2019 (COVID-19) refers to infection with the severe acute respiratory syndrome 2 (SARS-CoV-2) pathogen, and has spread pandemic levels since its inception in December 2019. While several risk factors for presentation have been identified, clinical course end-stage renal (ESRD) patients on maintenance hemodialysis COVID-19 unclear. Previous studies revealed that some antiviral agents may be effective against general population, but pharmacokinetics pharmacodynamics...
Osp94 (osmotic stress protein of 94 kDa) is known to be up-regulated by hypertonic and heat-shock stresses in mouse renal inner medullary collecting duct (mIMCD3) cells. To investigate the molecular mechanism transcriptional regulation gene under these stresses, we cloned characterized 5´-flanking region gene. Sequence analysis proximal 4 kb revealed a TATA-less G/C-rich promoter containing cluster Sp1 sites. We also identified upstream sequence motifs similar consensus TonE/ORE...
Combinatorial gene regulation by multiple microRNAs (miRNAs) is widespread and closely spaced target sites often act cooperatively to achieve stronger repression ("neighborhood" miRNA cotargeting). While cotarget are suggested be more conserved implicated in developmental control, the pathological significance of cotargeting remains elusive.
Aromatic C–H amination chemistry has attracted significant attention as an alternative to conventional of aryl halides. Among reactions, dehydrogenative coupling arenes and N–H reagents represents ideal transformation because prefunctionalization steps or aminating are not required. Herein, we report direct C–H/N–H between naphthalene sulfonimides mediated by 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) a photosensitizer under irradiation blue light. attentions
ISAKA Y
Abstract Stomata—small pores generally found on the leaves of plants—control gas exchange between plant and atmosphere. Elucidating mechanism that underlies such control through regulation stomatal opening/closing is important to understand how plants regulate photosynthesis tolerate against drought. However, up-to-date, molecular components their function involved in are not fully understood. We challenged problem a chemical genetic approach by isolating characterizing synthetic molecules...
Some variables including age, comorbidity of diabetes, and so on at dialysis initiation are associated with patient prognosis. Cardiovascular (CV) events a major cause death, adequate models that predict prognosis in patients warranted. Therefore, we created using some initiation. We used database 1,520 consecutive (median 70 years; 492 women [32.4%]) from multicenter prospective cohort study. established the primary endpoint as composite incidence first CV or all-cause death. A...
Abstract Background Kidney and life outcomes remain unsatisfactory in patients with microscopic polyangiitis (MPA). Appropriate treatment intensity must be provided to the appropriate patients. To identify severe cases early, we investigated factors related kidney outcomes. Methods We included diagnosed MPA based on myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) positivity histopathology results after biopsies between January 1, 2021, May 11, 2023, at 10 affiliated centers,...
Background In patients with chronic kidney disease (CKD), prevalence of sleep apnoea syndrome (SAS) is reported to be markedly high. However, the factors associated severity SAS in such rarely have been reported.Methods This was a cross-sectional study 100 stable non-dialysis CKD who attended educational programme from April 2014 August 2015. Diagnosis and its were assessed using type-3 portable monitor.Results Eighty-six men 14 women mean age 71.6 ± 9.7 years included. Mean apnoea-hypopnoea...
Several reports have discussed the risk factors for acute kidney injury (AKI) after thoracic aortic surgery and dissection increased mortality in patients with AKI. However, there are few on AKI combined medical surgical treatment influence mortality. The aim of this study was to clarify long-term effects function a cohort at our hospital. We retrospectively investigated 96 initial between April 2012 January 2015. divided subjects into two groups: 65 31 without using RIFLE criteria. outcomes...
Sepsis is a systemic inflammatory response syndrome caused by infectious disease. Severe sepsis and septic shock are extremely serious conditions with poor prognoses. It reported that cytokines deeply involved in the disease mechanism. Continuous hemodiafiltration (CHDF) using poly(methyl methacrylate) (PMMA) membrane to adsorb various improve status of patients sepsis. Recently, another cytokine-adsorbing hemofilter, acrylonitrile-co-methallyl sulfonate surface-treated (AN69ST) membrane,...
Introduction There are few studies on the association between serum uric acid (UA) level and mortality in incident dialysis patients. We aimed to clarify whether UA at initiation is associated with during maintenance dialysis.Methods enrolled 1486 patients who participated a previous multicenter prospective cohort study Japan. classified into following five groups according their levels initiation: G1 <6 mg/dL; G2, 6.0–8.0 G3, 8.0–10.0 G4, 10.0–12.0 G5, ≥12.0 mg/dL. created three models...
Recently, sleep apnea syndrome (SAS) has been associated with hypertension, cardiovascular disease and death. Patients chronic kidney (CKD) have higher rates of SAS, atherosclerotic complications death than do patients without CKD. Although the relationship between SAS atherosclerosis is well known, few papers described this in humans, especially CKD patients.This was a cross-sectional study 110 clinically stable, non-dialysis who attended educational program from April 2014 to September...
Introduction: As glomerular filtration rate (GFR) decreases, serum phosphate level increases. Previous reports indicated that was associated with mortality in patients on dialysis. However, few have examined the association using dialysis initiation as baseline period.Methods: This a multicenter prospective cohort analysis including 1492 patients. Patients were classified into four quartiles based at initiation, Q1 being lowest and Q4 highest. All-cause after compared log-rank test. The...
Several human studies reported that the combined use of renin-angiotensin system blockers (RASBs) and vitamin D receptor activators (VDRAs) resulted in decreased urinary protein excretion. However, it is unknown whether this combination therapy influences incidence cardiovascular (CV) events dialysis patients.The study was a multicenter nonrandomized prospective cohort analysis including 1,518 patients. Patients were classified into 4 groups based on medications prescribed before initiation:...
Acute-phase patients sometimes require hemodialysis therapy without vascular access (VA) present on admission. These VA creation to continue after discharge. The risk of early failure in acute-phase conditions is considered high due the unstable nature patients’ condition. Hence, optimal timing not established. This retrospective study included who had (arteriovenous fistula or graft) created between May 2010 and July 2016. During this study, 913 creations were performed among 804 patients....
Hypertension is common in patients with chronic kidney disease. Whether blood pressure management before dialysis initiation influences prognosis during maintenance remains unclear. Hence, we surveyed the status of antihypertensive drug use incident patients. Moreover, examined association between patterns at time and mortality. We used a database derived from multicenter prospective Aichi Cohort Study Prognosis Patients Newly Initiated into Dialysis, which included 1520 prefecture, Japan....