A5056750962- Electronic Packaging and Soldering Technologies
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- 3D IC and TSV technologies
- Drilling and Well Engineering
- Tunneling and Rock Mechanics
- Advanced Welding Techniques Analysis
- Rock Mechanics and Modeling
- Hormonal Regulation and Hypertension
- Geotechnical and Geomechanical Engineering
- Vasculitis and related conditions
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- Copper Interconnects and Reliability
- Nerve Injury and Rehabilitation
- Vitamin D Research Studies
- Silicon Carbide Semiconductor Technologies
- Genetic Syndromes and Imprinting
- Semiconductor materials and interfaces
- Advanced machining processes and optimization
- Metal Forming Simulation Techniques
- Aluminum Alloys Composites Properties
- Neurological Complications and Syndromes
- Crystal structures of chemical compounds
- Chemical Synthesis and Analysis
Tokai University
2010-2024
Erasmus University Rotterdam
2022
National Cancer Institute
2022
Tulane University
2022
Monash University
2022
University of Utah
2022
Northwestern University
2022
Kagawa University
2022
Furukawa Electric (United Kingdom)
2004-2019
Niigata Prefectural Central Hospital
2011-2018
Journal Article Molecular Cloning and Characterization of 9 cDNAs for Genes That Are Responsive to Desiccation in Arabidopsis thaliana: SequenceAnalysis One cDNA Clone Encodes a Putative Transmembrane Channel Protein Get access Kazuko Yamaguchi-Shinozaki, Yamaguchi-Shinozaki 1Plant Biology Laboratory, Institute Physical Chemical Research (RIKEN)3-1-1 Koyadai, Tsukuba, Ibaraki, 305 Japan Search other works by this author on: Oxford Academic Google Scholar Masahiro Koizumi, Koizumi...
Elevated fibroblast growth factor 23 (FGF23) is associated with adverse clinical outcomes and development of secondary hyperparathyroidism (SHPT) refractory to active vitamin D. Cinacalcet hydrochloride effective in treating SHPT, but little known as whether treatment cinacalcet alters these levels pretreatment FGF23 predict response this therapy.We measured serum full-length 55 haemodialysis patients, who participated completed the 52-week, multicentre, open-label single-arm trial that...
Abstract Two-thirds of urate is excreted via the renal pathway and remaining one-third extra-renal pathway, latter mainly intestine in healthy individuals. ABCG2, a exporter, expressed various tissues including kidney intestine, its dysfunction leads to hyperuricemia gout. ABCG2 regarded as being responsible for most excretion. However, excretion capacity remains undefined end-stage diseases. Therefore, we evaluated using 123 anuric hemodialysis patients whose depended on only pathway....
Reliability enhancement of thick Al wire bonds during thermal fatigue test has been investigated from a metallurgical viewpoint. degrade with the increase crack length tests high /spl Delta/T/sub j/ due to tensile stress generated by expansion coefficient mismatch between wires and Si. It is also found that cracks propagate along small grain boundaries at bonding interface. predicted may not if controlled below 40 K, i.e., keeping it within actual temperature fluctuation range in IGBT...
The reliability of Cu/Al bonds was compared with that Au/Al to establish reliable copper ball bonding for IC's. Diffusion-controlled intermetallic compound phases CuAl and. <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> were identified in. the interfaces after isothermal aging by micro-X-ray diffraction. In addition, diffusion-controlled Au xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> Al,...
Although the alpha-chymases of primates and dogs are known as chymotrypsin-like proteases, enzymatic properties rodent (rat mast cell protease 5/rMCP-5 mouse 5/mMCP-5) have not been fully understood. We report that recombinant rMCP-5 mMCP-5 elastase-like proteases. An enzyme assay using chromogenic peptidyl substrates showed protease-5s (MCP-5s) a clear preference for small aliphatic amino acids (e.g. alanine, isoleucine, valine) in P1 site substrates. used site-directed mutagenesis computer...
We have previously shown that podocyte injury increases the glomerular filtration of liver-derived Agt (angiotensinogen) and generation intrarenal Ang II (angiotensin II) filtered is reabsorbed by proximal tubules in a manner dependent on megalin. In present study, we aimed to study role megalin renal sodium handling during nephrotic syndrome. generated tubule-specific KO (knockout) mice crossed these animals with NEP25 mice, which podocyte-specific can be induced injection immunotoxin LMB2....
SLPI (secretory leukocyte protease inhibitor) is a 107-residue non-glycosylated inhibitor, which inhibits wide range of serine proteases, trypsin, chymotrypsin, neutrophil elastase, chymase and cathepsin G. X-ray crystallographic analyses have shown that comprises two separate domains similar architecture [Grütter, Fendrich, Huber & Bode (1988), EMBO J. 7, 345-351] the C-terminal domain interacts with bovine alpha-chymotrypsin. In order to understand SLPI's multiple functions against various...
Klotho is a transmembrane protein that acts as cofactor for fibroblast growth factor 23 (FGF23). also exists soluble circulating protein, but its role in secondary hyperparathyroidism (SHPT) largely unknown.We measured serum levels 51 haemodialysis patients, who participated and completed 52-week, multicentre, open-label single-arm trial examined the effectiveness of cinacalcet treating SHPT.After 12 weeks treatment, decreased significantly (P = 0.03) only marginally from 398 pg/mL...
Objective The purpose of this study was to measure serum 25-hydroxyvitamin D [25(OH)D] levels in Japanese patients with diabetic nephropathy and determine the relationship between 25(OH)D concentrations various factors.
Recently, it has been reported that 25% of plasma angiotensinogen (Agt) is derived from fat. Meanwhile, liver-specific Agt knockout (KO) mice have markedly low Agt, which may be due to reduced fat mass. To study the contribution we tested whether increasing mass can elevate and blood pressure in liver- KO mice. Epididymal fed a high-fat diet (HFD) was 4.1-fold larger than on normal-fat (NFD). The NFD were hypotensive with levels (on average, 0.11 vs 2.38 μg/ml). HFD slightly increased (0.17...
Effect of ball-forming conditions on the microstructure and hardness balls has been investigated in order to obtain soft suitable for a reliable ball-bonding process using copper wire. Copper formed room-temperature shield gas are found be harder by 6 Hv than fully annealed wires same purity. This is caused many dislocation loops which generated due inclusion gaseous impurities from atmosphere rapid solidification. On other hand, heated above 175 °C softer amount 4.5 gas. disappearance...
Patients with chronic kidney failure have markedly elevated fibroblast growth factor 23 (FGF-23) levels and decreased soluble Klotho levels. However, no studies examined the effects of hemodialysis initiation on these hormones other parameters mineral metabolism.Prospective single-arm study.20 individuals incident initiating hemodialysis.Initiation hemodialysis. Dose adjustments phosphate binders vitamin D receptor activators use calcimimetics, erythropoiesis-stimulating agents, intravenous...
To derive and validate a clinical prediction model with high sensitivity for differentiating aseptic meningitis (AM) patients from bacterial (BM) patients.We developed the using derivation cohort in community rural hospital Okinawa assessed its performance validation metropolitan urban Tokyo. There were 66 (39.5%) 5 (17.9%) adult BM among (n=167) (n=28), respectively. Recursive partitioning analysis was used to determine important classification variables develop sensitive safely exclude...