A5016609632- Acute Myeloid Leukemia Research
- Echinoderm biology and ecology
- Chronic Myeloid Leukemia Treatments
- Marine and coastal plant biology
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Coral and Marine Ecosystems Studies
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Multiple Myeloma Research and Treatments
- Insect behavior and control techniques
- Ocean Acidification Effects and Responses
- Microbial Community Ecology and Physiology
- Autophagy in Disease and Therapy
- Identification and Quantification in Food
- Offshore Engineering and Technologies
- Crustacean biology and ecology
- Lepidoptera: Biology and Taxonomy
- Pregnancy and Medication Impact
- Skin and Cellular Biology Research
- Plant and animal studies
- Hormonal and reproductive studies
- Marine Biology and Ecology Research
- Electrolyte and hormonal disorders
- HIV/AIDS drug development and treatment
National Institute of Genetics
2016-2025
Kōchi University
2023
Kochi Medical School Hospital
2023
RIKEN Center for Integrative Medical Sciences
2023
Suita Municipal Hospital
2023
Osaka University
2023
Takeda (Japan)
2023
Kyoto University
2006-2008
Bank of Japan
2006-2008
Abstract Acute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation (OxPhos) for survival, and they continually adapt to fluctuations in nutrient oxygen availability the bone marrow (BM) microenvironment. We investigated how BM microenvironment affects response OxPhos inhibition AML by using a novel complex I inhibitor, IACS-010759. Cellular adhesion, growth, apoptosis assays, along with measurements of expression mitochondrial DNA generation reactive species...
A major challenge in analyzing the data from high-throughput next-generation sequencing (NGS) is how to handle huge amounts of and variety NGS tools visualize resultant outputs. To address these issues, we developed a cloud-based analysis platform, Maser (Management Analysis System for Enormous Reads), an original genome browser, Genome Explorer (GE). enables users manage up 2 terabytes conduct analyses with easy graphical user interface operations offers pipelines which several individual...
To understand the mystery of life, it is important to accumulate genomic information for various organisms because whole genome encodes commands all genes. Since Strongylocentrotus purpratus was sequenced in 2006 as first echinoderms, resources other North American sea urchins have gradually been accumulated, but no urchin genomes are available areas, where many scientists used local species and reported results. In this manuscript, we report a draft Hemincentrotus pulcherrimus has long...
Tyrosine kinase inhibitors (TKIs) are established drugs in the therapy of FLT3-ITD mutated acute myeloid leukemia (AML). However, acquired mutations, such as D835 tyrosine domain (FLT3-ITD/D835), can induce resistance to TKIs. A cap analysis gene expression (CAGE) technology revealed that BCL2A1 transcription start sites was increased primary AML cells bearing FLT3-ITD/D835 compared FLT3-ITD. Overexpression attenuated sensitivity quizartinib, a type II TKI, and venetoclax, selective BCL2...
While epidemiological and experimental studies have demonstrated kidney-protective effects of estrogen female sex in adulthood, some data showed deterioration kidney function during puberty when production increases. However, molecular mechanisms explaining these conflicting phenomena remain unknown. Here, we that the pubertal hormone surge mice increases susceptibility to ischemia reperfusion injury partly via downregulation insulin-like growth factor 1 receptor (IGF-1R) expression proximal...
SUMMARY The larval skeletons of sea urchins show considerable morphological diversity, even between closely related species, although the evolutionary history and functional significance this diversity are poorly understood. To infer skeletal morphology, we focused on echinometrid species for which variation in had been investigated qualitatively quantitatively. We reconstructed phylogenetic relationships among 14 based mitochondrial ND1 ND2 genes mapped characters onto resultant trees....
Sea urchins have a long history as model organisms in biology, but their use genetics is limited because of breeding cycle. In sea urchin genetics, genome editing technology was first established Hemicentrotus pulcherrimus, whose has already been published. However, this species also cycle, new that are more suitable for sought. Here, we report draft another Western Pacific species, Temnopleurus reevesii, which recently since comparable developmental process to other short cycle...
To clarify the morphological variety of larval skeletons, a detailed comparison among species family Echinometridae was performed. Through conspecific skeletons different ages, we found five skeletal characters body skeleton that are stable in four-armed pluteus and thus useful homologous species. The variation summarized as difference number spines posteroventral transverse rods, differences shape skeleton. Significant correlations were between some characters, such upper length bottom...
<title>Abstract</title> To identify genes that are essential for cellular and organ functions, we established a homozygous mutant mouse embryonic stem cell bank from which identified gene, named<italic>Attenuated Hematopoietic Development (Ahed)</italic>, plays an role in hematopoiesis. Here characterize the of<italic>Ahed</italic>in skin development by analyzing mice with epidermis-specific Ahed deficiency (EcKO). Those have increased numbers of apoptotic cells epidermis fetal stage....