A5003083461- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Diabetes and associated disorders
- Bone health and treatments
- Renal and related cancers
- Complement system in diseases
- Renal cell carcinoma treatment
- Hormonal and reproductive studies
- Electrolyte and hormonal disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Aortic aneurysm repair treatments
- Pregnancy and Medication Impact
- Aortic Thrombus and Embolism
- Parathyroid Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Tuberous Sclerosis Complex Research
- Genetic Syndromes and Imprinting
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- IL-33, ST2, and ILC Pathways
- Infective Endocarditis Diagnosis and Management
- Metabolomics and Mass Spectrometry Studies
- Liver Diseases and Immunity
Kyoto University
2021-2025
Toranomon Hospital
2017-2020
Kansai Electric Power Hospital
2018
Tertiary lymphoid tissues (TLTs) are ectopic structures induced by multiple stimuli, including infection and tissue injuries; however, their clinical relevance in disease progression has remained unclear. We demonstrated previously that TLTs develop mouse human kidneys with aging can be a potential marker of kidney injury prognosis, therapeutic targets. In addition, we found two types unique lymphocytes emerge aging, senescence-associated T cells age-associated B cells, essential for TLT...
While epidemiological and experimental studies have demonstrated kidney-protective effects of estrogen female sex in adulthood, some data showed deterioration kidney function during puberty when production increases. However, molecular mechanisms explaining these conflicting phenomena remain unknown. Here, we that the pubertal hormone surge mice increases susceptibility to ischemia reperfusion injury partly via downregulation insulin-like growth factor 1 receptor (IGF-1R) expression proximal...
An 88-year-old Japanese man received bevacizumab for colorectal cancer with liver and peritoneal metastasis, during which nephrotic range proteinuria occurred (7.66 g/day). Renal biopsy showed endothelial damage subendothelial swelling a double contour of the glomerular basement membrane, indicated diagnosis thrombotic microangiopathy (TMA). After was stopped, decreased to 1 g/day. During clinical course, this patient had no extrarenal manifestations. This case suggests that renal injury...
A 79-year-old man was admitted to our hospital for proteinuria due nephrotic syndrome.Renal biopsy revealed focal sclerosis and foam cell infiltration in the glomerulus.In addition, electron microscopic findings (EM) peculiar electrondense deposits (EDDs) both sides of glomerular basement membrane.Although subepithelial had spike formation highly resembling those seen membranous nephropathy (MN), immunoglobulins complements were not identified by immunofluorescence study, microbubbles...
We evaluated the efficacy of everolimus in 3 patients who had huge renal angiomyolipomas associated with tuberous sclerosis complex. Two large lipid-rich a history transarterial embolization for bleeding, but effect only been temporary and embolized kidneys continued to enlarge. In case 1, 2, 3, total volume was respectively 3,891, 4,035, 1,179 cm3 before administration everolimus, decreasing 3,016 (77%), 3,043 (75%), 1,051 (89%) after 1 year therapy 2,832 (73%), 3,209 (80%), 1,102 (93%)...
Cryoglobulinemic vasculitis (CV) presents with systemic manifestations, including renal disease, arthritis, peripheral neuropathy, and muscle weakness. We encountered two patients who developed severe nephrotic range proteinuria; however, extrarenal manifestations were not noted during the clinical course. A biopsy revealed typical membranoproliferative glomerulonephritis (MPGN) huge thrombus-like endothelial deposits predominant IgM positivity, but electron microscopy did reveal any...
We report a 33-year-old Japanese man diagnosed with mixed connective tissue disease (MCTD) who developed nephrotic proteinuria. Both speckled antinuclear antibody (ANA) and anti-U1 ribonucleoprotein (RNP) were positive, but anti-double-stranded DNA (dsDNA) anti-Smith (Sm) negative, while complement levels normal. Renal biopsy revealed membranous glomerulonephritis (MGN) diffuse thickening of the glomerular basement membrane (GBM) plus spike bubble formation. Immunofluorescence demonstrated...
We report the case of a 67-year-old Japanese woman with type 1 diabetes mellitus. At 47 years age, her hemoglobin A1c (HbA1c) was 10.0%, and she had overt nephropathy. The first renal biopsy yielded diagnosis diabetic Intensive glycemic control initiated HbA1c improved to 6.0%. Renal dysfunction showed no progression for 15 years. 62 second performed. Glomerular lesions did not show but tubulointerstitial fibrosis vascular compared biopsy. can prevent glomerular lesions, might be effective...
We report a 48-year-old Japanese man with brown tumor of the right distal tibia. At age 25 years, hemodialysis was initiated due to nail-patella syndrome. Severe secondary hyperparathyroidism and osteoporosis progressed over time, so parathyroidectomy performed at 45. Spontaneous fracture tibia occurred suddenly 48. Imaging studies revealed bone tumor-like lesion surgery performed. The resected specimen mass consisting multinucleated giant cells on fibrous tissue background, these findings...
<title>Abstract</title> Volatile organic compounds resulting from metabolic processes are released as biogas, and potentially can serve noninvasive biomarkers of cellular health. During ferroptosis, a form cell death caused by lipid peroxidation (LPO), oxidized fragments be biogas. We identified ω-6 PUFA-derived volatile lipids (VOLs) produced cells undergoing metal-dependent LPO. Among several VOLs, 1-octen-3-ol 2-pentylfuran, were validated ferroptosis markers in vitro cultured cells, vivo...
We encountered 2 patients with symptomatic huge simple renal cysts. In case 1, 4,000 mL of cyst fluid was drained via a catheter, but intracystic bleeding occurred immediately afterwards. Transcatheter arterial embolization (TAE) performed, after which the stopped, and drainage repeated successfully. After years, total volume reduced from 11,775 to 75.4 mL. 2, TAE performed prophylactically before drainage. Subsequently, 9,400 removed multiple 1 year, 9,215 633 without bleeding. Based on...
Diabetic kidney disease (DKD) is the major cause of end stage renal disease. Despite best current treatment, it difficult to stop progression DKD. We report a 77-year-old Japanese man in whom rheumatoid arthritis (RA) was diagnosed at age 30 years, followed by type 2 diabetes mellitus (T2DM) 55. His haemoglobin A1c (HbA1c) around 7–9%, even after starting insulin therapy. function deteriorated steadily, with estimated glomerular filtration rate (eGFR) decreasing mL/min/1.73 m2 per year reach...
We report a 38-year-old Japanese man in whom lupus membranous nephropathy was diagnosed by renal biopsy. Steroid therapy initiated, followed cyclophosphamide and calcineurin inhibitors. Although serum markers for the activity of nephritis (LN) showed improvement, his function gradually declined. During this period, biopsy repeated three times whenever proteinuria increased, revealing progression with an increase epithelial immune deposits. Electron microscopy first specimen did not clearly...