A5004302551- Reproductive Biology and Fertility
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Pain Mechanisms and Treatments
- Surgical site infection prevention
- Gastrointestinal disorders and treatments
- Reconstructive Surgery and Microvascular Techniques
- Gastrointestinal Tumor Research and Treatment
- Computational Drug Discovery Methods
- Sarcoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Stroke Rehabilitation and Recovery
- Veterinary Pharmacology and Anesthesia
- Sperm and Testicular Function
- Cardiac tumors and thrombi
- Pituitary Gland Disorders and Treatments
- Cancer-related Molecular Pathways
- Ultrasound in Clinical Applications
- Assisted Reproductive Technology and Twin Pregnancy
- Reconstructive Facial Surgery Techniques
- Diagnosis and Treatment of Venous Diseases
- Neuroendocrine Tumor Research Advances
- Uterine Myomas and Treatments
Tokushima University
2002-2025
Shizuoka Saiseikai General Hospital
2024
Osaka City University
2013-2022
Tokushima University Hospital
2021
Osaka Medical and Pharmaceutical University
2018
The University of Tokyo
2016
Kitasato University
2015
Ohkawara Neurosurgical Hospital
2015
Osaka University
2010-2012
Kobe City Medical Center General Hospital
2011
Abstract Numerous COVID-19 diagnostic imaging Artificial Intelligence (AI) studies exist. However, none of their models were potential clinical use, primarily owing to methodological defects and the lack implementation considerations for inference. In this study, all development processes deep-learning are performed based on strict criteria “KAIZEN checklist”, which is proposed previous AI guidelines overcome deficiencies mentioned above. We develop evaluate two binary-classification triage...
Summary objective The molecular events leading to the development of GH‐secreting pituitary tumours remain largely unknown. Gsα ( GNAS1 ) mutations are found in 27–43% sporadic adenomas Caucasian population, but frequency Japanese and Korean acromegalic patients was reported be lower, 4–9% 16%, respectively. Other genes responsible for tumourigenesis have not been detected yet. PRKAR1A , which codes RIα regulatory subunit cyclic AMP‐dependent protein kinase A (PKA) on 17q23–24, recently...
Alterations in the expression of mucin family members play an important role as well alterations oncogenes and onco-suppressor genes carcinogenesis progression pancreatic cancer. We analyzed localization MUC1, MUC2, MUC5AC small intestinal antigen (SIMA) tumors. MUC1 was observed almost all samples, whereas MUC2 not. 73.9% cancerous regions, 48.7% dysplastic regions 72.0% hyperplastic but not normal duct. SIMA 45.7% 17.9% 8.0% regions. Furthermore, stromal 37.0%, 60.9% 26.1% respectively....
[Purpose] The efficacy of diffusion tensor imaging in the prediction motor outcomes and activities daily living function remains unclear. We evaluated most appropriate parameters methodology to determine whether region interest- or tractography-based method was more useful for predicting stroke patients. [Subjects Methods] Diffusion data within 10 days after onset were collected analyzed 25 corticospinal tract analyzed. Fractional anisotropy, number fibers, apparent coefficient used as...
Synovial sarcoma is a soft-tissue and rare type of cancer. Unfortunately, effective chemotherapies for synovial sarcomas have not been established. In this report, we show that cell lines reduced repair activity DNA damage induced by ionizing radiation (IR) topoisomerase II inhibitor (etoposide). We also observed recruitment RAD51 homologue (S. cerevisiae; RAD51) at sites double-strand breaks (DSBs) in had exposed to IR. These findings showed are defective homologous recombination (HR)...
Tramadol is thought to modulate synaptic transmissions in the spinal dorsal horn mainly by activating µ-opioid receptors and inhibiting reuptake of monoamines CNS. However, precise mode modulation remains unclear. We used an vivo patch clamp technique urethane-anesthetized rats determine antinociceptive mechanism tramadol. In whole-cell recordings spontaneous inhibitory postsynaptic currents (sIPSCs) excitatory (sEPSCs) were made from substantia gelatinosa (SG) neurons (lamina II) at holding...
BackgroundVolatile anesthetics suppress noxiously evoked activity in the spinal dorsal horn, which could contribute part to analgesia, immobility. Modulation of excitatory and inhibitory synaptic transmission substantia gelatinosa neurons lead suppression horn activity; however, this phenomenon has not yet been investigated fully. MethodsIn urethane-anesthetized rats, extracellular (action potentials) excitatory/inhibitory postsynaptic currents were recorded using vivo patch-clamp...
Dogs with ovarian papillary adenocarcinoma occasionally present ascites and/or pleural effusion. These aspirated fluids often contain a large number of cells, and distinction between neoplastic cells activated mesothelial can be difficult. In this study, 7 cases canine adenocarcinoma, including 3 effusion, were immunohistochemically examined. Ovarian tumor positive for cytokeratin CAM5.2 (CAM5.2), Wilms' 1 (WT-1) progesterone receptor (PR) in all cases. A metastatic lesion the mediastinum...
To assess the morphological findings based on transvaginal ultrasound, ovarian volume and number size of small follicles were studied in 47 patients with polycystic syndrome (PCOS) diagnosed clinically. Thirty normal volunteers served as controls. The mean (10.3 ml) (10.6) PCOS significantly higher than those An > 6.2 ml 10 a diameter 2-8 mm most prominent features ovaries 94% had at least one these ultrasonic findings. However, marked asymmetry two was seen about 50% considerable overlap...
A 69-year-old man presented with a rare case of retinal artery embolization, which occurred as complication carotid angioplasty and stenting performed for recurrent cerebral infarction. Magnetic resonance imaging angiography showed right internal stenosis ulceration. Carotid were using the distal protection system PercuSurge GuardWire. However, just after dilation, patient complained ocular pain blurred vision on right, was subsequently diagnosed embolization. Heparin given 15 hours...
The side effects that occur in the central nervous system and circulatory due to medicines are expected be prevented by research development. However, many of compounds have possibility causing arrhythmia, methods developed detect this problem at early stage drug development not always successful. In present study, we classified according their activity using only structural information. To classify compounds, used a self-organizing map (SOM), which is nonlinear unsupervised classification...
We have reviewed chemoinformatics approaches for drug discovery such as aromatic interactions, clusters, structure generation, virtual screening, de novo design, evolutionary algorithm, inverse-QSPR/QSAR, Monte Carlo, molecular dynamics, fragment orbital method and matched pair analysis from the viewpoint of young researchers. intend to introduce various fields non-expert The this review is given follows: 1. Introduction, 2. Analysis Aromatic Interactions, 2.1 2.2 Clusters, 3. Ligand Based...
【目的】MERCIリトリーバーを用いた機械的急性脳動脈再開通療法（mechanical thrombectomy）を我が国で安全に展開するため，本治療に導入初期から積極的に取り組んだ施設の周術期の治療結果を調査し報告した．【方法】2011年2月までに本治療を4例以上経験した19施設のうち15施設から報告を受けた119例の経験をまとめた．これはこの間の本邦における経験症例の42.0%，対象施設の経験数の88.1%に相当した．【結果】 平均年齢71.0歳，男性80（67.2%），閉塞血管は，内頚動脈40.3%，中大脳動脈49.5%，椎骨脳底動脈9.2%で，平均入院時NIHSSは18.1，rt-PA静注療法先行42.0%，発症から穿刺までの平均時間は340.3分，他の血管内治療手技の併用は56.7%である．再開通はTICI Grade 2A以上が74.6%，2B以上が48.3%，AOL...
To assess the usefulness of transvaginal ultrasound scanning (TVS) for screening in polycystic ovarian (PCO) disease, we symptomatically and endocrinologically compared 9 cases (group A) with PCO noted by transabdominal (TAS) 8 B) TVS only. No difference mean value LH/FSH ratio, E1/E2 ratio testosterone was observed between two groups. However, frequency endocrine abnormalities, menstrual disorders hypertrichosis group A significantly more than B. Therefore, suggest that stage TAS is...