A5013652383- Hypothalamic control of reproductive hormones
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Regulation of Appetite and Obesity
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Marine Toxins and Detection Methods
- Biochemical Analysis and Sensing Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Pancreatic function and diabetes
- Esophageal and GI Pathology
- Appendicitis Diagnosis and Management
- Photoreceptor and optogenetics research
- Hernia repair and management
- Marine Biology and Environmental Chemistry
- Environmental Toxicology and Ecotoxicology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Nagoya University
2013-2024
Japanese Red Cross Medical Center
2019
Ibaraki Prefectural Central Hospital
2009-2016
The University of Tokyo
2006-2015
Jichi Medical University
2010-2014
Kyushu University
2012
Teine Keijinkai Hospital
2012
Yamagata University Hospital
2012
Tokai University
2010
Japan Science and Technology Agency
2003-2007
Objective: The aim of this study was to elucidate the clinicopathological features and prognosis mucinous cystic neoplasms (MCNs). Materials Methods: We performed a multi-institutional, retrospective on collected series patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological were investigated. Result: Mucinous neoplasm confirmed in 156 cases, including 129 adenomas (82.7%) 21 noninvasive (13.4%) 6 invasive carcinomas (3.9%). Patients exclusively women (98.1%)...
The pars tuberalis of the pituitary gland is regulatory hub for seasonal reproduction in birds and mammals. Although fish also exhibit robust responses, they do not possess an anatomically distinct tuberalis. Here we report that saccus vasculosus a sensor. We observe expression key genes regulating rhodopsin family masu salmon. Immunohistochemical studies demonstrate all these are expressed coronet cells vasculosus, suggesting existence photoperiodic signalling pathway from light input to...
Familiarity Does Not Breed Contempt Female mating preference is influenced by social familiarity in various species from fish to primates. Okuyama et al. (p. 91 ) showed Japanese rice that females prefer mate with visually familiarized males over unfamiliar and this mediated specific neuromodulatory neurons the female brain.
Objectives There have been only a few reports on follow-up results of serous cystic neoplasm (SCN) the pancreas. The frequency malignancy and surgical indication SCN are not determined yet. Methods In this multi-institutional study Japan Pancreas Society, total 172 patients with were enrolled. mean period was 4.5 years. Surgical resection performed in 90 patients, whereas remaining 82 simply observed. Results Of all 20% symptomatic. tumor located pancreatic head (39%), body (35%), tail...
GnRH neurons in the preoptic area and hypothalamus control secretion of form final common pathway for hypothalamic-pituitary-gonadal axis regulation vertebrates. Temporal reproduction by coordinating endogenous physiological conditions behaviors is important successful reproduction. Here, we examined temporal measuring time-of-day-dependent changes electrical activity GnRH1 levels expression pituitary gonadotropin mRNA using a daily spawning teleost, medaka (Oryzias latipes). First,...
Feedback controls of estrogen in LHRH-1 neurons play a pivotal role reproductive function. However, the mechanism action is still unclear. In present study, effect estrogens on intracellular calcium ([Ca2+]i) oscillations primate was examined. Application 17β-estradiol (E2, 1 nm) for 10 min increased frequency [Ca2+]i within few minutes. E2 also synchronization among neurons. Similar effects were observed under presence tetrodotoxin, indicating that appears to cause direct Moreover,...
We have shown previously that cultured LHRH-1 neurons, derived from monkey olfactory placode region, exhibit pulsatile release at hourly intervals and spontaneous intracellular calcium oscillations, which synchronize a frequency similar to release. Brief application of estrogen induced rapid increase in the oscillations synchronizations. The estrogen-induced was mediated by receptors (ER), whereas synchronizations not ER. In present study, we further examined action using patch-clamp...
Two types of gonadotropins, luteinizing hormone (LH) and follicle stimulating (FSH), are important pituitary hormones for sexual maturation reproduction, both them centrally regulated by gonadotropin-releasing (GnRH) from the hypothalamus. In mammals, these two gonadotropins secreted a single type gonadotrope. The mechanisms differential regulation GnRH release with different secretory profiles still unknown. teleosts, however, LH FSH separate cellular populations, unlike in mammals. This...
Gonadotropin-releasing hormone (GnRH) neurons in the terminal nerve (TN) show endogenous pacemaker activity, which is suggested to be dependent on physiological conditions of animal. The TN-GnRH have been function as a neuromodulatory neuron that regulates long-lasting changes animal behavior. It has reported are immunoreactive FMRFamide. Here, we find activity inhibited by FMRFamide: bath application FMRFamide decreased frequency dose-dependent manner. This decrease was suppressed blockage...
Abstract Toxic puffers contain the potent neurotoxin, tetrodotoxin (TTX). Although TTX is considered to serve as a defense substance, previous behavioral studies have demonstrated that acts an attractive pheromone for some toxic puffers. To elucidate physiological mechanism of putative pheromonal action TTX, we examined whether grass Takifugu alboplumbeus can detect TTX. Electroolfactogram (EOG) results suggest olfactory epithelium (OE) responded type analog (5,6,11-trideoxyTTX), although it...
The terminal nerve (TN)-gonadotropin-releasing hormone (GnRH) neurons project widely in the brain instead of pituitary and show endogenous pacemaker activity that is dependent on physiological conditions animal. We suggest TN-GnRH system may act as a putative neuromodulator involved regulation many long-lasting changes animal's behavior. In present study, we find modulated by salmon GnRH (sGnRH), which same molecular species peptide produced themselves. Bath application sGnRH (2–200 nM)...
GnRH2 is a molecule conserved from fish to humans, suggesting its important functions. However, recent studies have shown that neurons project widely in the brain but not pituitary, which suggests their functions other than stimulation of gonadotropin secretion. In contrast wealth knowledge GnRH1 and GnRH3 neuronal systems, system remains be studied, there has been no single cell approach so far, partly because lack rodents. Here, we generated GnRH2-green fluorescent protein (GFP) transgenic...
Gonadotropin-releasing hormone (GnRH) is well known as a hypophysiotropic that produced in the hypothalamus and facilitates release of gonadotropins from pituitary gonadotropes. On other hand, functions extrahypothalamic GnRH systems still remain elusive. Here we examined whether activity olfactory bulbar neural circuits modulated by originates mainly terminal nerve (TN) system goldfish ( Carassius auratus). As morphological basis, first observed TNs express salmon (sGnRH) mRNA...
Teleosts possess two or three paralogs of gonadotropin-releasing hormone (GnRH) genes: gnrh1, gnrh2, and gnrh3. Some species have lost the gnrh1 and/or gnrh3 genes, whereas gnrh2 has been completely conserved in teleost analyzed to date. In most teleosts that GnRH1 peptide is authentic GnRH stimulates gonadotropin release, GnRH2 GnRH3, if present, are neuromodulatory. Progenitors GnRH3 neurons originate from olfactory placodes migrate their destination during early development. However,...
Abstract Toxic puffers accumulate their defense substance (tetrodotoxin; TTX) through the food chain. Although previous study suggests that 5,6,11-trideoxyTTX, a nontoxic TTX analog detected simultaneously with in toxic or prey, acts as an olfactory chemoattractant for grass puffers, it is unclear whether are commonly attracted to and which types of sensory neurons (OSNs) detect 5,6,11-trideoxyTTX. Here, we demonstrated green spotted puffer, phylogenetically distant species from...
Kisspeptin (Kiss) neurons show drastic changes in kisspeptin expression response to the serum sex steroid concentration various vertebrate species. Thus, according reproductive states, are suggested modulate neuronal activities, including regulation of GnRH mammals. However, despite their state-dependent regulation, there is no physiological analysis seasonal breeders. Here we generated first kiss1-enhanced green fluorescent protein transgenic line a breeder, medaka, for histological and...
The terminal nerve gonadotropin-releasing hormone (TN-GnRH) neurons show spontaneous pacemaker activity whose firing frequency is suggested to regulate the release of GnRH peptides and control motivation for reproductive behaviors. Previous studies electrophysiological properties TN-GnRH reported excitatory modulation by auto/paracrine synaptic modulations, but inhibition has not been date. Our recent study suggests that neuropeptide FF, a type Arg-Phe-amide (RFamide) peptide expressed in...
Retrocecal hernia is rare and involves strangulation ileus, therefore, frequently requires emergency surgery following conservative therapy.We report an interesting case of a retrocecal in 65-year-old man, with history diabetes mellitus. The patient was admitted to our hospital severe periumbilical pain nausea. Abdominal computed tomography revealed intestinal obstruction at pericecal site, dilatation the small bowel oral side obstruction. initially treated therapy using long tube placement....