A5015493481- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- COVID-19 and Mental Health
- SARS-CoV-2 detection and testing
- Renal Transplantation Outcomes and Treatments
- Medical Imaging and Pathology Studies
- Polyomavirus and related diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes and associated disorders
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pulmonary Hypertension Research and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neonatal Respiratory Health Research
- Tryptophan and brain disorders
- Tracheal and airway disorders
- Eosinophilic Disorders and Syndromes
- Congenital Diaphragmatic Hernia Studies
- Animal Virus Infections Studies
UNSW Sydney
2014-2025
St Vincent's Hospital
2019-2025
St Vincent's Hospital Sydney
2015-2025
St Vincent's Clinic
2019-2025
The University of Sydney
2022-2025
St Vincent's Health
2023-2025
St. Vincent's Hospital
2022-2024
Saint Vincent's Catholic Medical Center
2022-2024
St. Vincent's Birmingham
2022-2024
Children's Medical Research Institute
2024
BackgroundGenetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction global vaccine programs has contributed to lower COVID-19 hospitalisation and mortality rates, particularly in developed countries. In late 2021, Omicron BA.1 emerged, with substantially altered genetic differences clinical effects from other concern. Shortly after dominating spread early 2022, was supplanted by the genetically...
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants variant of concern (VOC) are unknown, but critical to understand reinfection risk breakthrough infection following vaccination. Antibody immunoreactivity against SARS-CoV-2 antigens Spike variants, inhibition Spike-driven virus–cell fusion, infectious were characterized in 807 serial samples from 233 reverse transcription polymerase chain reaction...
Abstract This study investigates the humoral and cellular immune responses health-related quality of life measures in individuals with mild to moderate long COVID (LC) compared age gender matched recovered COVID-19 controls (MC) over 24 months. LC participants show elevated nucleocapsid IgG levels at 3 months, higher neutralizing capacity up 8 months post-infection. Increased spike-specific nucleocapsid-specific CD4 + T cells, PD-1, TIM-3 expression on CD8 cells were observed but these...
Abstract Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. Over this time global vaccine programs introduced, contributing to lowered COVID-19 hospitalisation and mortality rates, particularly in the first world. In late 2021, Omicron (B.1.1.529) virus variant emerged, with significant genetic differences clinical effects from other concern (VOC). This demonstrated higher numbers polymorphisms gene...
Abstract Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start COVID-19 pandemic. Over this period, we developed a rapid platform (R-20) for viral isolation and characterization using primary remnant diagnostic swabs. This, combined with quarantine testing genomics surveillance, enabled all major SARS-CoV-2 circulating in Australia 2021. Our facilitated variant isolation, resolution fitness nasopharyngeal swabs ranking...
To determine the prevalence and natural history of post-acute COVID-19 objective cognitive impairment function, their relationship to demographic, clinical factors, sequelae (PASC), biomarkers.A total 128 patients (age = 46 ± 15; 42% women, acute disease severity: not hospitalized: 38.6% mild: 0-1 symptoms, 52% 2+ symptoms; 9.4% hospitalized) completed standard cognition, olfaction, mental health examinations 2-, 4-, 12-month post diagnosis. Over same time frame, WHO-defined PASC was...
Abstract A proportion of patients surviving acute COVID-19 infection develop post-COVID syndrome (long COVID) encompassing physical and neuropsychiatric symptoms lasting longer than 12 weeks. Here we studied a prospective cohort individuals with long COVID compared to age/gender matched subjects without (from the ADAPT study), healthy donors infected other non-SARS CoV2 human coronaviruses (the ADAPT-C study). We found highly activated innate immune cells an absence subsets un-activated...
Objective To investigate the association between blood–brain barrier permeability, brain metabolites, microstructural integrity of white matter, and cognitive impairment (CI) in post-acute sequelae SARS-COV-2 infection (PASC). Methods In this multimodal longitudinal MRI study 14 PASC participants with CI 10 healthy controls were enrolled. All completed investigations at 3 months following acute (3 ± 2 weeks SD), 12 2.22 SD weeks. The assessments included a standard neurological assessment,...
Abstract Cognitive impairment and function post-acute mild to moderate COVID-19 are poorly understood. We report findings of 128 prospectively studied SARS-CoV-2 positive patients. Cognition olfaction were assessed at 2-, 4- 12-months post-diagnosis. Lung function, physical mental health 2-month post diagnosis. Blood cytokines, neuro-biomarkers, kynurenine pathway (KP) metabolites measured 4-, 8- 12- months. Mild cognitive (demographically corrected) was present in 16%, 23%, 26%, diagnosis,...
Background. Chronic lung allograft dysfunction (CLAD) is a major contributor to poor long-term survival after transplantation (LTx). There paucity of validated tissue biomarkers which limits the early detection CLAD. The aim this study was discover novel proteins in Methods. A longitudinal cohort analyzed 15 specimens from 2 groups bilateral LTx recipients; those with CLAD (n = 3) and without 3). In both groups, transbronchial biopsies (TBBx) were retrieved timepoints; stable surveillance at...
Eosinophilic (EOS) allograft inflammation is detected after lung transplant (LTx) in ~10% recipients. A retrospective study showed that it an independent risk factor for both chronic dysfunction (CLAD) and rejection [1,2]. The presence of EOS associated with higher grades acute cellular (ACR), however, also observed the absence histologic ACR [3,4]. mechanisms by which poor long-term outcomes remains unclear. may contribute to ongoing tissue injury, or reflect tolerogenic repair pathways....
Abstract Background Individuals with Long COVID experience substantial burden of illness many months after initial infection. Few studies have comprehensively and longitudinally assessed health outcomes for people following mild/moderate We applied the Wilson-Cleary model health-related quality life (HRQOL) to describe impact on multiple dimensions up 24 COVID-19 Methods Participants within ADAPT post-COVID study (n=172, 86% infection) completed structured patient-reported outcome measures...
<b>In a longitudinal cohort, significant proportion of patients had persistent symptoms 8 months after initial #COVID19 infection. There was no improvement in or health-related quality life between 4- and 8-month assessments.</b>https://bit.ly/2Wtb7IX
Background Long-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population order reduce ongoing disease burden. Methods We have investigated association between memory CD4 CD8 cells levels convalescent COVID-19 subjects. Findings Higher titres were associated with significantly higher RBD-specific cells, specific that proliferated vigorously vitro . Conversely, up half individuals had low...
A high-risk epitope mismatch (REM) (found in DQA1∗05 + DQB1∗02/DQB1∗03:01) is associated with de novo donor specific antibodies after lung transplantation (LTx). Chronic allograft dysfunction (CLAD) remains a barrier to LTx survival. This study aimed measure the association between DQ REM and risk of CLAD death LTx. retrospective analysis recipients at single center was conducted January 2014 April 2019. Molecular typing human leucocyte antigen-DQA/DQB identified REM. Multivariable competing...
Abstract Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. Over this time global vaccine programs introduced, contributing to lowered COVID-19 hospitalisation and mortality rates, particularly in the first world. In late 2021, Omicron (B.1.1.529) virus variant emerged, with significant genetic differences clinical effects from other concern (VOC). This a demonstrated higher number polymorphisms gene...