A5037032836- Indoor Air Quality and Microbial Exposure
- DNA and Nucleic Acid Chemistry
- Carcinogens and Genotoxicity Assessment
- Research on Leishmaniasis Studies
- Heavy Metal Exposure and Toxicity
- Trypanosoma species research and implications
- RNA and protein synthesis mechanisms
- Analytical chemistry methods development
- Heavy metals in environment
- Advanced Chemical Sensor Technologies
- HIV/AIDS drug development and treatment
- Air Quality and Health Impacts
- Advanced biosensing and bioanalysis techniques
- Vitamin D Research Studies
- Chemical Synthesis and Analysis
- Thyroid Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Toxic Organic Pollutants Impact
- Smoking Behavior and Cessation
- Alcohol Consumption and Health Effects
- Pharmacological Effects and Toxicity Studies
- Effects and risks of endocrine disrupting chemicals
- Synthesis and Biological Evaluation
Centers for Disease Control and Prevention
2016-2022
National Center for Environmental Health
2016-2022
Georgia State University
2008-2011
The causative agents for the current national outbreak of electronic-cigarette, or vaping, product use-associated lung injury (EVALI) have not been established. Detection toxicants in bronchoalveolar-lavage (BAL) fluid from patients with EVALI can provide direct information on exposure within lung.BAL fluids were collected 51 16 states and 99 healthy participants who part an ongoing study smoking involving nonsmokers, exclusive users e-cigarettes vaping products, cigarette smokers that was...
Volatile organic compounds (VOCs) are ubiquitous in the environment. In United States (U.S.), tobacco smoke is major non-occupational source of exposure to many harmful VOCs. Exposure VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment Tobacco and Health (PATH) Study a U.S. national longitudinal study use adult youth civilian non-institutionalized population. We measured 20 VOCMs urine specimens from subsample adults Wave 1 (W1) (2013-2014)...
To determine what topological changes antiparasitic heterocyclic dications can have on kinetoplast DNA, we constructed ligation ladders, with phased A5 and ATATA sequences in the same flanking sequence context, as models. Bending by tract is observed, expected, while bends DNA very little. Complexes of these DNAs three diamidines containing either furan, thiophene or selenophene groups flanked phenylamidines were investigated along netropsin. With bent ladder compounds caused a slight...
Heterocyclic diamidines are compounds with antiparasitic properties that target the minor groove of kinetoplast DNA. The mechanism action these is unknown, but topological changes to DNA structures likely be involved. In this study, we have developed a polyacrylamide gel electrophoresis-based screening method determine effects heterocyclic on four sequences: AAAAA, TTTAA, AAATT and ATATA. AAAAA sequences largest intrinsic bend, whereas TTTAA ATATA relatively straight. caused by binding...
Benzene is a known genotoxic carcinogen linked to many hematological abnormalities. S-phenylmercapturic acid (PHMA, N-acetyl-S-(phenyl)-L-cysteine, CAS# 4775-80-8) urinary metabolite of benzene and used as biomarker assess exposure. Pre-S-phenylmercapturic (pre-PHMA) PHMA precursor that dehydrates at acidic pH. Published analytical methods measure adjust urine samples wide range pH values using several types acid, potentially leading highly variable results depending on the concentration...
Abstract Objectives Matrix differences among serum samples from non-pregnant and pregnant patients could bias measurements. Standard Reference Material 1949, Frozen Human Prenatal Serum, was developed to provide a quality assurance material for the measurement of hormones nutritional elements throughout pregnancy. Methods Serum women in each trimester were bottled into four levels based on pregnancy status trimester. Liquid chromatography tandem mass spectrometry (LC-MS/MS) methods applied...