A5042802608- Mass Spectrometry Techniques and Applications
- Advanced Chemical Sensor Technologies
- Analytical chemistry methods development
- Air Quality and Health Impacts
- Analytical Chemistry and Chromatography
- Indoor Air Quality and Microbial Exposure
- Air Quality Monitoring and Forecasting
- Carcinogens and Genotoxicity Assessment
- Nuclear Physics and Applications
- Toxic Organic Pollutants Impact
- Ion-surface interactions and analysis
- Occupational exposure and asthma
- Smoking Behavior and Cessation
- Energetic Materials and Combustion
- Diet and metabolism studies
- Solar and Space Plasma Dynamics
- Geophysics and Gravity Measurements
- Adipose Tissue and Metabolism
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Plasma Diagnostics and Applications
- Neuroscience and Neuropharmacology Research
- Chemical Safety and Risk Management
- Water Treatment and Disinfection
- Cannabis and Cannabinoid Research
National Center for Environmental Health
2010-2025
Centers for Disease Control and Prevention
2011-2025
University of the Pacific
2024
Combat Capabilities Development Command Soldier Center
2015
The Centers
2015
Lambda
2013
Atomic Weapons Establishment
2012
Lawrence Livermore National Laboratory
1993-2002
National Technical Information Service
2000
Office of Scientific and Technical Information
2000
The causative agents for the current national outbreak of electronic-cigarette, or vaping, product use-associated lung injury (EVALI) have not been established. Detection toxicants in bronchoalveolar-lavage (BAL) fluid from patients with EVALI can provide direct information on exposure within lung.BAL fluids were collected 51 16 states and 99 healthy participants who part an ongoing study smoking involving nonsmokers, exclusive users e-cigarettes vaping products, cigarette smokers that was...
CDC, the Food and Drug Administration (FDA), state local health departments, multiple public clinical partners are investigating a national outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). Based on data collected as October 15, 2019, 86% 867 EVALI patients reported using tetrahydrocannabinol (THC)-containing products in 3 months preceding symptom onset (1). Analyses THC-containing samples by FDA laboratories have identified potentially harmful constituents...
A significant portion of the increased risk cancer and respiratory disease from exposure to cigarette smoke is attributed volatile organic compounds (VOCs). In this study, 21 VOCs were quantified in mainstream 50U.S. domestic brand varieties that included high market share brands 2 Kentucky research cigarettes (3R4F 1R5F). Mainstream was generated under ISO 3308 Canadian Intense (CI) smoking protocols with linear machines a gas sampling bag collection followed by solid phase...
Quantifying volatile organic compounds (VOCs) in cigarette smoke is necessary to establish smoke-related exposure estimates and evaluate emerging products potential reduced-exposure products. In response this need, we developed an automated, multi-VOC quantification method for machine-generated, mainstream using solid-phase microextraction gas chromatography–mass spectrometry (SPME-GC–MS). This was simultaneously quantify a broad range of VOCs (i.e., carbonyls volatiles, which historically...
Exposure assessment of hazardous volatile organic compounds (VOCs) requires accurate quantification internal dose when establishing limits or identifying significant differences within and among populations. Even though can be directly measured in blood, it is not always practical possible to collect a suitable blood specimen. This work studies the relationship between urine levels for certain smoke biomarkers (e.g., tobacco, marijuana) self-reported cigarette smokers. Urine specimens were...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMatrix-assisted laser desorption of biological molecules in the quadrupole ion trap mass spectrometerDavid M. Chambers, Douglas E. Goeringer, Scott A. McLuckey, and Gary L. GlishCite this: Anal. Chem. 1993, 65, 1, 14–20Publication Date (Print):January 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ac00049a005https://doi.org/10.1021/ac00049a005research-articleACS PublicationsRequest...
A recently developed atomic emission source, the microwave plasma torch (MPT), is evaluated as an element-selective detector for gas chromatography (GC) and capillary supercritical fluid (SFC). The interfaces between chromatograph or MPT are described. effects of GC-SFC experimental conditions on analytes studied. Two alternative types discharges identified their comparative utility in GC-SFC-MPT detection investigated. introduction SFC mobile phase (in this instance CO2) has less effect He...
Our objective was to improve understanding of the differences in use behavior and exposure when smoking menthol non-menthol cigarettes using a 2-part cross-over design.Adult daily smokers were assigned randomly alternate between 2 weeks exclusively test cigarette or cigarette. Urine saliva collected for biomarker measurements; carbon monoxide (CO) measured, participants smoked through CreSS® topography device during 3 clinic visits. Participants turned their butts from periods determination...
Studies of exposure to petroleum (crude oil/fuel) often involve monitoring benzene, toluene, ethylbenzene, xylenes (BTEX), and styrene (BTEXS) because their toxicity gas-phase prevalence, where is typically by inhalation. However, BTEXS levels in the general U.S. population are primarily from tobacco smoke, smokers have blood on average up eight times higher than nonsmokers. This work describes a method using partition theory artificial neural network (ANN) pattern recognition classify...
Nail technicians are exposed to volatile organic compounds (VOCs) from nail products, but no studies have previously measured VOC biomarkers for these workers. This study of 10 aimed identify VOCs in salons and explore relationships between air concentrations biomarkers. Personal area samples were collected using thermal desorption tubes during a work shift analyzed gas chromatography/mass spectrometry (GC/MS) 71 VOCs. Whole blood pre-shift post-shift, GC/MS 43 Ventilation rates determined...
Widespread exposure to benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) the potential for this cause health effects drives need develop improved methods measuring exposure. In work, we demonstrate our latest assay quantifying BTEXS in blood characterize sources of both positive negative biases. This method involves sample collection using common techniques followed by static headspace sampling solid-phase microextraction gas chromatography/mass spectrometry analysis. We found that...
We describe here a new method for the analysis of alkanes ( n-hexane, n-heptane, n-octane, n-nonane, n-decane, n-undecane, and n-dodecane) in blood using headspace solid-phase microextraction gas chromatography/mass spectrometry. This is used to measure picogram per milliliter levels n-alkanes that may result from nonoccupational exposure other volatile nonpolar compounds common sources such as petroleum-based fuel. alkane signature useful distinguishing typical fuel biomarkers (e.g.,...
Biomonitoring, or the measurement of environmental chemicals in human tissues and fluids, is used to supplement—and some cases replace—more traditional exposure assessments which measure media. Volatile organic compounds (VOCs) physiological fluids are biomarkers that present numerous challenges for sample collection analysis. To date, a thorough evaluation methods analysis breast milk samples volatiles has not been conducted. In this paper, we describe development validation collecting,...
Trichloroethylene (TCE) in groundwater has the potential to volatilize through soil into indoor air where it can be inhaled. The purpose of this study was determine whether individuals living above TCE-contaminated are exposed TCE vapor intrusion. We examined associations between concentrations various environmental media and residents. For assessment, air, outdoor gas, tap water samples were collected around 36 randomly selected homes; blood from 63 residents these homes. Additionally, a...
A time-of-flight mass spectrometer (TOF-MS) that incorporates an ion storage trap as a pulsed extraction source and sample preconcentrator has been developed for air monitoring. This new instrument configuration is designed real-time monitoring of changes in trace volatile semivolatile compound concentrations air. Typically, detection limits are the low parts per billion (v/v) range. store/TOF-MS permits relatively large volume flux to be drawn directly into cavity, creating local pressure...
Urinary diamines are biomarkers of diisocyanate exposure. Diisocyanates considered as skin and respiratory sensitizers the most frequently reported cause occupational asthma. Herein we report on development validation an ultraperformance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method for measurement five aromatic diamines, 4,4′-methylenedianiline (MDA), 2,4-toluenediamine (4TDA), 2,6-toluenediamine (6TDA), 1,5-naphthalenediamine (NDA), p-phenylenediamine (PPDA) in human...
A 9-mm torch and a 40.68-MHz radiofrequency power supply were evaluated for use in inductively coupled plasma mass spectrometry (ICP-MS). With this system, an analytically useful can be supported at 850 W applied r.f. 8.7 l min–1 total argon flow-rate. The effects of operating parameters (nebuliser gas flow-rate, power, sampling depth ion-lens voltages) on the analyte ion signals determined. source exhibits greater independence ion-optic bias potential relative atomic than do...
Widespread use of the gasoline additive methyl tert-butyl ether (MTBE) and subsequent human exposure that follows have led to need quantify MTBE in a variety complex biological matrixes. In this work, we demonstrate our latest quantification assay for whole blood uncover previously unidentified contamination sources prevented routine low picogram per milliliter (parts trillion, ppt) range despite sensitive selective analytical approach. The most significant unexpected were found reagents...