Naomi Waithira
A5015824023- Malaria Research and Control
- Mosquito-borne diseases and control
- COVID-19 Pandemic Impacts
- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Computational Drug Discovery Methods
- Long-Term Effects of COVID-19
- Global Maternal and Child Health
- Pharmacological Effects and Toxicity Studies
- Ethics in Clinical Research
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Antibiotic Resistance in Bacteria
- Viral Infections and Vectors
- Vaccine Coverage and Hesitancy
- Neonatal Health and Biochemistry
- Artificial Intelligence in Healthcare
- Hemoglobinopathies and Related Disorders
- Hepatitis Viruses Studies and Epidemiology
- Research Data Management Practices
- Data Analysis and Archiving
Mahidol Oxford Tropical Medicine Research Unit
2018-2025
Mahidol University
2018-2025
University of Oxford
2018-2025
Angkor Hospital for Children
2022
Cambodia-Oxford Medical Research Unit
2022
Christian Medical College & Hospital
2021
Wellcome Trust
2014
The emergence and spread of resistance in Plasmodium falciparum malaria to artemisinin combination therapies the Greater Mekong subregion poses a major threat control elimination. current study is part multi-country, open-label, randomised clinical trial (TRACII, 2015-18) evaluating efficacy, safety, tolerability triple therapies. A very high rate treatment failure after with dihydroartemisinin-piperaquine was observed Thailand, Cambodia, Vietnam. immediate public health importance our...
Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment delay emergence of antimalarial resistance.
The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.
Primaquine is the only widely used drug that prevents Plasmodium vivax malaria relapses, but adherence to standard 14-day regimen poor. We aimed assess efficacy of a shorter course (7 days) primaquine for radical cure malaria.We did randomised, double-blind, placebo-controlled, non-inferiority trial in eight health-care clinics (two each Afghanistan, Ethiopia, Indonesia, and Vietnam). Patients (aged ≥6 months) with normal glucose-6-phosphate dehydrogenase (G6PD) presenting uncomplicated were...
Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding malaria sequence ME-TRAP conferred 67% protection against infection Plasmodium falciparum in Kenyan adults.
To understand the impact of COVID-19 and public health measures on different social groups, we conducted a mixed-methods study in five countries ('SEBCOV-social, ethical behavioural aspects COVID-19'). Here, report results online survey.Overall, 5058 respondents from Thailand, Malaysia, UK, Italy Slovenia completed self-administered survey between May June 2020. Poststratification weighting was applied, associations categorical variables assessed. Frequency counts percentages were used to...
In southeast Asia, antibiotic prescription in febrile patients attending primary care is common, and a probable contributor to the high burden of antimicrobial resistance. The objective this trial was explore whether C-reactive protein (CRP) testing at point could rationalise care, comparing two proposed thresholds classify CRP concentrations as low or guide treatment.
Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions possible; yet, in reality, the volume of remains low. Health researchers other producers are reluctant to share their unless they confident datasets high quality reliable, used accordance values aims institutions. We argue having an institutional, departmental or group management sharing policy is first step towards encouraging healthcare...
Malaria in the eastern Greater Mekong subregion has declined to historic lows. Countries are accelerating malaria elimination context of increasing antimalarial drug resistance. Infections now increasingly concentrated remote, forested foci. No intervention yet shown satisfactory efficacy against forest-acquired malaria. The aim this study was assess chemoprophylaxis among forest goers Cambodia.
In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity mortality. Village health workers (VHWs) are often the first point contact with formal system, patients they can provide early diagnosis treatment malaria. However, majority patients, VHWs lack training, support resources to further care. Consequently, treatable bacterial missed, antibiotics overused poorly targeted, patient attendance wanes along This Open Letter...
Background Circulating markers of immune and endothelial activation risk stratify infection syndromes agnostic to disease aetiology. However, their utility in children presenting from the community remains unclear. Methods This study recruited aged 1-59 months with community-acquired acute febrile illnesses seven hospitals Bangladesh, Cambodia, Indonesia, Laos, Viet Nam. Clinical parameters biomarker concentrations were measured at presentation. The outcome measure was death or receipt vital...
Background Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show benefit of HCQ against COVID-19 and, although meta-analysis suggest clinical benefit, guidelines recommend use. Methods findings Healthy adult participants from the healthcare setting, later community,...
Triple antimalarial combination therapies combine potent and rapidly cleared artemisinins or related synthetic ozonides, such as arterolane, with two, more slowly eliminated partner drugs to reduce the risk of resistance. We aimed assess safety, tolerability, efficacy arterolane-piperaquine-mefloquine versus arterolane-piperaquine artemether-lumefantrine for treatment uncomplicated falciparum malaria in Kenyan children.
There are no pharmacokinetic data of single low dose primaquine (SLDPQ) as transmission blocking in African children with acute Plasmodium falciparum and glucose-6-phosphate dehydrogenase deficiency (G6PDd).
<ns4:p><ns4:bold>Background</ns4:bold>: Antimicrobial resistance (AMR) / drug resistant infections (DRIs) are a major global health priority. Surveillance data is critical to inform infection treatment guidelines, monitor trends, and assess interventions. However, most existing AMR DRI surveillance systems passive pathogen-based with many potential biases. Addition of clinical patient outcome would provide considerable added value surveillance.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>:...
<h2>Summary</h2><h3>Background</h3> WHO recommends gametocytocidal, single low-dose primaquine for blocking the transmission of <i>Plasmodium falciparum</i>; however, safety concerns have hampered implementation this strategy in sub-Saharan Africa. We aimed to investigate age-dosed, children from Uganda and Democratic Republic Congo. <h3>Methods</h3> conducted randomised, double-blind, placebo-controlled, non-inferiority trial at Mbale Regional Referral Hospital, Mbale, Uganda, Kinshasa...
The World Health Organization recommends that primaquine should be given once weekly for 8-weeks to patients with Plasmodium vivax malaria and glucose-6-phosphate dehydrogenase (G6PD) deficiency, but data on its antirelapse efficacy safety are limited.Within the context of a multicentre, randomised clinical trial two regimens in P. malaria, G6PD deficiency were excluded enrolled into separate 12-month observational study. They treated dose 0.75 mg/kg 8 weeks (PQ8W) plus dihydroartemisinin...
<ns4:p><ns4:bold>Background</ns4:bold>: Antimicrobial resistance (AMR) / drug resistant infections (DRIs) are a major global health priority. Surveillance data is critical to inform infection treatment guidelines, monitor trends, and assess interventions. However, most existing AMR DRI surveillance systems passive pathogen-based with many potential biases. Addition of clinical patient outcome would provide considerable added value surveillance.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>:...
<ns3:p>In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity mortality. Village health workers (VHWs) are often the first point contact with formal system, patients they can provide early diagnosis treatment malaria. However, majority patients, VHWs lack training, support resources to further care. Consequently, treatable bacterial missed, antibiotics overused poorly targeted, patient attendance wanes along...
In locations where few people have received coronavirus disease 2019 (COVID-19) vaccines, health systems remain vulnerable to surges in severe acute respiratory syndrome 2 (SARS-CoV-2) infections. Tools identify patients suitable for community-based management are urgently needed.
Introduction In low-income and middle-income countries in Southeast Asia, the burden of diseases among rural population remains poorly understood, posing a challenge for effective healthcare prioritisation resource allocation. Addressing this knowledge gap, South Asia Community-based Trials Network (SEACTN) will undertake survey that aims to determine prevalence wide range non-communicable communicable diseases, as one key initiatives its first project—the Rural Febrile Illness project...
Introduction In rural and difficult-to-access settings, early accurate recognition of febrile children at risk progressing to serious illness could contribute improved patient outcomes better resource allocation. This study aims develop a prognostic clinical prediction tool assist community healthcare providers identify who might benefit from referral or admission for facility-based medical care. Methods analysis prospective observational will recruit least 4900 paediatric inpatients...