A5057943710- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Public Health and Nutrition
- Healthcare Quality and Satisfaction
- Dengue and Mosquito Control Research
- Tuberculosis Research and Epidemiology
- COVID-19 epidemiological studies
- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- Malaria Research and Control
- COVID-19 Prevention and Impact
- Insect and Pesticide Research
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- HIV/AIDS Impact and Responses
- Healthcare Systems and Reforms
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Virology and Viral Diseases
- Data-Driven Disease Surveillance
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
Universitas Gadjah Mada
2016-2025
ADA University
2017-2020
Public Health Department
2017
Institute for Medical Research
2015
Erasmus University Rotterdam
2012
Erasmus MC
2009-2012
Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia pipientis are less susceptible than wild-type A. to dengue virus infection.We conducted a cluster-randomized trial involving releases wMel-infected for control in Yogyakarta, Indonesia. We randomly assigned 12 geographic clusters receive deployments (intervention clusters) and no (control clusters). All practiced local mosquito-control measures as usual. A test-negative design was used assess efficacy intervention. Patients...
<ns4:p><ns4:bold>Background: </ns4:bold><ns4:italic>Ae. aegypti</ns4:italic> mosquitoes stably transfected with the intracellular bacterium <ns4:italic>Wolbachia</ns4:italic> <ns4:italic>pipientis</ns4:italic> (<ns4:italic>w</ns4:italic>Mel strain) have been deployed for biocontrol of dengue and related arboviral diseases in multiple countries. Field releases northern Australia previously demonstrated near elimination local transmission from <ns4:italic>Wolbachia</ns4:italic>-treated...
The successful establishment of the wMel strain Wolbachia for control arbovirus transmission by Aedes aegypti has been proposed and is being implemented in a number countries. Here we describe four sites Yogyakarta, Indonesia. We demonstrate that can be successfully introgressed after transient releases wMel-infected eggs or adult mosquitoes. approach acceptable to communities maintains itself mosquito population once deployed. Finally, our data show spreading rates Indonesian setting are...
Dengue and other arboviruses transmitted by Aedes aegypti mosquitoes, including Zika chikungunya, present an increasing public health challenge in tropical regions. Current vector control strategies have failed to curb disease transmission, but continue be employed despite the absence of robust evidence for their effectiveness or optimal implementation. The World Mosquito Program has developed a novel approach arbovirus using Ae. stably transfected with Wolbachia bacterium, significantly...
The AWED (Applying Wolbachia to Eliminate Dengue) trial is a parallel, two-arm, non-blinded cluster randomised controlled that under way in Yogyakarta, Indonesia, with the aim of measuring efficacy Wolbachia-infected Aedes aegypti deployments reducing dengue incidence an endemic setting. Enrolment began January 2018 and ongoing. original study protocol was published April 2018. Here, we describe amendments have been made since commencement trial.The key are (1) revised duration planned end...
Background Releases of Wolbachia (wMel)-infected Aedes aegypti mosquitoes significantly reduced the incidence virologically confirmed dengue in a previous cluster randomised trial Yogyakarta City, Indonesia. Following trial, wMel releases were extended to untreated control areas, achieve city-wide coverage Wolbachia.Objective In this predefined analysis, we evaluated impact deployments on hemorrhagic fever (DHF) case notifications and frequency perifocal insecticide spraying by public health...
Identifying fine-scale spatial patterns of disease is essential for effective control and elimination programmes. In low resource areas without formal addresses, novel strategies are needed to locate residences individuals attending health facilities in order efficiently map patterns. We aimed assess the use Android tablet-based applications containing high resolution maps geolocate individual residences, whilst comparing functionality, usability cost three software packages designed collect...
Background Circulating markers of immune and endothelial activation risk stratify infection syndromes agnostic to disease aetiology. However, their utility in children presenting from the community remains unclear. Methods This study recruited aged 1-59 months with community-acquired acute febrile illnesses seven hospitals Bangladesh, Cambodia, Indonesia, Laos, Viet Nam. Clinical parameters biomarker concentrations were measured at presentation. The outcome measure was death or receipt vital...
Marsha S. Santoso, M.D, M.I.P.H., Eggi Arguni, Ph.D., Bunga Rana, M.Sc., Mercy E. Adiniko, Dionisius Denis, Endah Supriyati, Citra Indriani, M.P.H., Leily Trianty, Riris Andono Ahmad, Rintis Noviyanti, and R. Tedjo Sasmono, Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0558
The dengue situation in the urban setting of Hanoi city, Vietnam, is emerging, focusing on inner districts. Previous studies showed that a vector control program was not effective because lack adequate engagement local government authorities, health sector, and community. This implementation research aimed to explore barriers implementing community an district city. Ten in-depth interviews 14 focus group discussions were conducted at Lang Thuong, Khuong Tho Quan, Kim Lien wards Dong Da...
Abstract Background In order to improve malaria burden estimates in low transmission settings, more sensitive tools and efficient sampling strategies are required. This study evaluated the use of serological measures from repeated health facility-based cross-sectional surveys investigate Plasmodium falciparum vivax dynamics an area nearing elimination Indonesia. Methods Quarterly were conducted eight public facilities Kulon Progo District, Indonesia, May 2017 April 2018. Demographic data...
In response to the COVID-19 pandemic, mobile-phone data on population movement became publicly available, including Google Community Mobility Reports (CMR). This study explored utilization of mobility predict dynamics in Jakarta, Indonesia. We acquired aggregated and anonymized sets from 15 February 31 December 2020. Three statistical models were explored: Poisson Regression Generalized Linear Model (GLM), Negative Binomial GLM, Multiple (MLR). Due multicollinearity, three categories reduced...
Introduction Worldwide, the 33 recognised megacities comprise approximately 7% of global population, yet account for 20% COVID-19 deaths. The specific inequities and other factors within that affect vulnerability to mortality remain poorly defined. We assessed individual, community-level healthcare associated with COVID-19-related in a megacity Jakarta, Indonesia, during two epidemic waves spanning 2 March 2020 31 August 2021. Methods This retrospective cohort included residents...
Abstract The intention-to-treat (ITT) analysis of the Applying Wolbachia to Eliminate Dengue (AWED) trial estimated a protective efficacy 77.1% for participants resident in areas randomised receive releases w Mel-infected Aedes aegypti mosquitoes, an emerging dengue preventive intervention. limiting assumptions ITT analyses cluster trials and mobility mosquitoes humans across boundaries indicate primary is likely underestimate full public health benefit. Using spatiotemporally-resolved data...
Breast cancer is the most common in women Indonesia. Patients' survival depends on various factors, namely patient-, tumor-, and treatment-related factors. Survival analysis Indonesian patients has only been reported a few studies. This study aimed to identify factors that are associated with five-year overall (OS) among breast at local tertiary hospital Indonesia.A retrospective cohort was conducted Dr Sardjito Hospital, Yogyakarta. Female diagnosed between January December 2009 were...
Dengue is endemic in Indonesia. Here, we describe the epidemiology of dengue city Yogyakarta, Central Java, as a prelude to implementation cluster-randomized trial Wolbachia for biocontrol arboviral transmission. Surveillance records from 2006 2016 demonstrate seasonal oscillations incidence with varying magnitude. Two lines evidence high force infection; hospitalized case burden patients diagnosed hemorrhagic fever or shock syndrome over last decade consisted predominantly...
Indonesia is one of the countries where dengue infection prevalent. In this study we measure prevalence and distribution virus (DENV) DENV-infected Aedes aegypti in Yogyakarta City, Indonesia, during wet season when high transmission period occurred, as baseline data before implementation a Wolbachia-infected trial for control. We applied One-Step Multiplex Real Time PCR (RT-PCR) type-specific-detection viruses field-caught adult mosquitoes. prospective field conducted from December 2015 to...
Abstract Background Dengue is an emerging vector disease with frequent outbreaks in Nepal that pose a major threat to public health. control activities are mostly outbreak driven, and still lack systematic interventions while most people have poor health-related knowledge practices. Mobile Short Message Service (SMS) represents low-cost health promotion intervention can enhance the dengue prevention practices of affected communities. This study aimed explore acceptability, appropriateness,...
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised that demonstrated ( w Mel) introgression into Ae . aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative abundance of and albopictus before, during after Mel-introgression. Between March 2015 2020, 60,084 BG trap collections yielded 478,254 17,623 arms there no measurable difference in before or Mel-deployments, with count ratio 0.96...
Introduction In Indonesia, a country with around 280 million people and the second-highest tuberculosis (TB) incidence rate in world, impact of COVID-19 pandemic on TB care needs careful assessment so that future response strategies can be strengthened. We conducted study comparing testing treatment rates before during first 2 years reasons for any disruptions to care. Methods retrospective secondary data analysis qualitative interviews Yogyakarta Bandung, Indonesia. Routine were sourced...
HIV and HIV-TB co-infection are slowly increasing in Indonesia. WHO recommends testing among TB patients as a key response to the dual epidemic. Concerns over potential negative impacts control lack of operational clarity have hindered progress. We investigated barriers opportunities for introducing perceived by providers Jogjakarta, offered Voluntary Counselling Testing (VCT) parallel prevalence survey. conducted in-depth interviews with 33 patients, 3 specialist physicians disease...
Summary Objectives To understand determinants of care‐seeking patterns and diagnostic delay amongst tuberculosis (TB) patients diagnosed at direct observed treatment short course (DOTS) facilities in Jogjakarta, Indonesia. Methods Cross‐sectional survey newly TB 89 DOTS whose history was reconstructed through retrospective interviews gathering data on socio‐demographic determinants, onset symptoms, type health visited, duration each action were recorded. Results Two hundred fifty‐three...
We aimed to reparameterize and validate an existing dengue model, comprising entomological component (CIMSiM) a disease (DENSiM) for application in Malaysia. With the model we measure effect of importation rate on incidence, determine potential impact moderate climate change (a 1 °C temperature increase) activity. Dengue models (comprising CIMSiM DENSiM) were reparameterized simulated Malaysian village 10 000 people, validated against monthly case data from district Petaling Jaya state...
Background Even though conceptually, Tuberculosis (TB) is almost always curable, it currently the world’s leading infectious killer. Patients with pulmonary TB are source of transmission. Approximately 23% population believed to be latently infected bacteria, and 5–15% them will progress at any point in time develop disease. There was a global diagnostic gap 2.9 million between notifications new cases estimated number incident cases, Indonesia carries third-highest this gap. Therefore,...
We aimed to evaluate the incremental cost-effectiveness of engaging private practitioners (PPs) refer tuberculosis (TB) suspects public health centers in Jogjakarta, Indonesia. Effectiveness was assessed for TB notified between May 2004 and April 2005. Private referred 1,064 suspects, which 57.5% failed reach a center. The smear-positive rate among patients reaching center 61.8%. Two hundred eighty (280) out total 1,306 (21.4%) new cases were enrolled through PPs strategy. ratio per case...