A5040272329- Hemoglobinopathies and Related Disorders
- Malaria Research and Control
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
- Blood donation and transfusion practices
- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Neonatal Health and Biochemistry
- Travel-related health issues
- Clinical Nutrition and Gastroenterology
- Food Security and Health in Diverse Populations
- Diverse Scientific Research Studies
- Blood groups and transfusion
- Drug Transport and Resistance Mechanisms
- Blood transfusion and management
Mbale Hospital
2018-2023
Busitema University
2020-2023
Clinical Research Institute
2023
Soroti Hospital
2020
Kenya Medical Research Institute
2020
Imperial College London
2020
De Montfort University
2020
Dyson (United Kingdom)
2020
Guy's and St Thomas' NHS Foundation Trust
2020
Evelina London Children's Healthcare
2020
There are no pharmacokinetic data of single low dose primaquine (SLDPQ) as transmission blocking in African children with acute Plasmodium falciparum and glucose-6-phosphate dehydrogenase deficiency (G6PDd).
<h2>Summary</h2><h3>Background</h3> WHO recommends gametocytocidal, single low-dose primaquine for blocking the transmission of <i>Plasmodium falciparum</i>; however, safety concerns have hampered implementation this strategy in sub-Saharan Africa. We aimed to investigate age-dosed, children from Uganda and Democratic Republic Congo. <h3>Methods</h3> conducted randomised, double-blind, placebo-controlled, non-inferiority trial at Mbale Regional Referral Hospital, Mbale, Uganda, Kinshasa...
BackgroundThe TRACT trial established the timing of transfusion in children with uncomplicated anaemia (haemoglobin 4–6 g/dL) and optimal volume (20 vs 30 mL/kg whole blood or 10 15 red cell concentrates) for admitted to hospital severe <6 on day 28 mortality (primary endpoint). Because data safety components are scarce, we conducted a secondary analysis examine efficacy different pack types (whole clinical outcomes.MethodsThis study is restricted those who received an immediate (using...
<ns4:p><ns4:bold>Background</ns4:bold>: In Uganda to date, there are neither established registries nor descriptions of facility-based sickle cell disease (SCD) patient characteristics beyond the central region. Here, we summarize data on baseline clinical and routine care available patients at four clinics in Eastern as a prelude trial.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: Between February August 2018, conducted cross-sectional survey attending SCD Mbale, Soroti, Atutur Ngora, all...
<ns3:p><ns3:bold>Background: </ns3:bold>Changes in intestinal mucosal integrity and gut microbial balance occur severe acute malnutrition (SAM), resulting treatment failure adverse clinical outcomes (gram-negative sepsis, diarrhoea high case-fatality). Transient lactose intolerance, due to loss of brush border lactase, also complicates SAM, thus milk based feeds may not be optimal for nutritional rehabilitation. Since the epithelial barrier can supported by short chain fatty acids, derived...
: In Uganda to date, there are neither established registries nor descriptions of facility-based sickle cell disease (SCD) patient characteristics beyond the central region. Here, we summarize data on baseline clinical and routine care available patients at four clinics in Eastern as a prelude trial.
Abstract Background Children hospitalised with severe malnutrition (SM) have high mortality and relapse/readmission rates. Current milk-based formulations targets restoring ponderal growth but not modification of gut barrier integrety or microbiome which increase risk gram-negative sepsis poor outcomes. Objectives We propose that legume-based feeds rich in fermentable carbohydrates will promote better health improve overall Methods conducted at Mbale Regional Referral Hospital, Uganda an...
Single low-dose primaquine (SLDPQ) effectively blocks the transmission of Plasmodium falciparum malaria, but anxiety remains regarding its haemolytic potential in patients with glucose-6-phopshate dehydrogenase (G6PD) deficiency. We, therefore, examined independent effects several factors on haemoglobin (Hb) dynamics falciparum-infected children a particular interest SLDPQ and G6PD status.This randomised, double-blind, placebo-controlled, safety trial was conducted Congolese Ugandan aged 6...
Abstract Background: In high malaria transmission settings, there is paucity of data on the relationship between parasite density and severe forms. patients with malaria, we characterised for different clinical spectra assessed its association mortality. Methods : This was a cross sectional study conducted as part Malaria Epidemiological, Pathophysiological Intervention studies in Highly Endemic Eastern Uganda code named TMA 2016SF-1514-MEPIE Study , at Mbale Regional Referral Hospital...