A5073277273- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Diabetes and associated disorders
- Polysaccharides and Plant Cell Walls
- Postharvest Quality and Shelf Life Management
- Gut microbiota and health
- Thyroid Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Health and Biochemistry
- Neuroscience of respiration and sleep
- Growth Hormone and Insulin-like Growth Factors
- Erythrocyte Function and Pathophysiology
- Adrenal Hormones and Disorders
- T-cell and B-cell Immunology
- Digestive system and related health
- Salmonella and Campylobacter epidemiology
- Plant-Microbe Interactions and Immunity
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- SARS-CoV-2 and COVID-19 Research
- Vitamin D Research Studies
- Long-Term Effects of COVID-19
- Biofuel production and bioconversion
Universidad Andrés Bello
2013-2024
Millennium Institute on Immunology and Immunotherapy
2015-2024
University of the Americas
2022-2024
Pontificia Universidad Católica de Chile
2013-2024
Universidad de Las Américas
2023
Institute of Immunology
2021
University of Talca
2010-2017
Neurological deficits in the offspring caused by human maternal hypothyroxinemia are thought to be irreversible. To understand mechanism responsible for these neurological alterations, we induced pregnant rats. Behavior and synapse function were evaluated of thyroid hormone-deficient Our data indicate that, when compared with controls, hypothyroxinemic mothers bear litters adulthood, show prolonged latencies during learning process water maze test. Impaired capacity was consistent cellular...
Salmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The colonizes the proximal small intestine, penetrates epithelial layer, and engulfed by macrophages neutrophils. Intracellularly, S. encounters highly toxic reactive oxygen species including hydrogen peroxide hypochlorous acid. molecular mechanisms of resistance to oxidative stress not completely understood. ArcAB two-component a global...
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, first and rate-limiting step biosynthesis of hormones. The expression function NIS cells is mainly regulated by TSH intracellular concentration I-. High doses I- for 1 or 2 days inhibit synthesis hormones, a process known as Wolff-Chaikoff effect. cellular mechanisms responsible this physiological response are mediated part inhibition through reduction expression. Here we show that occurs early hours 5 after exposure to...
Fragaria vesca or 'woodland strawberry' has emerged as an attractive model for the study of ripening non-climacteric fruit. It several advantages, such its small genome and diploidy. The recent availability complete sequence opens possibility further analysis use a reference species. Fruit softening is physiological event involves many biochemical changes that take place at final stages fruit development; among them, remodeling cell walls by action set enzymes. Xyloglucan...
Background The prevalence of autism spectrum disorder (ASD) has significantly risen in the past three decades, prompting researchers to explore potential contributions environmental factors during pregnancy ASD development. One such factor interest is gestational hypothyroxinemia (HTX), a frequent condition associated with cognitive impairments offspring. While retrospective human studies have linked HTX autistic traits, cellular and molecular mechanisms underlying development ASD-like...
Maternal thyroid hormones play a fundamental role in appropriate fetal development during gestation. Offspring that have been gestated under maternal hypothyroidism suffer cognitive impairment. Thyroid hormone deficiency gestation can significantly impact the central nervous system by altering migration, differentiation, and function of neurons, oligodendrocytes, astrocytes. Given gestational alters immune cell ratio offspring, it is possible this condition could result higher sensitivity...
Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for tissue. Our study evaluates the impact eplerenone implantation upon obesity. Experimental Approach: Mice with implanted placebo pellets were fed a normal diet (ND) or high fat (HFD). Additionally, group mice HFD an pellet. Metabolic biochemical parameters assessed in each animal group. Adipocyte size...
The immunoreceptor-associated protein CD3ζ is known for its role in immunity and has also been implicated neuronal development synaptic plasticity. However, the mechanism by which regulates transmission remains unclear. In this study, we showed that mice lacking exhibited defects spatial learning memory as examined Barnes maze object location tasks. Given peripheral T cells have shown to support cognitive functions neural plasticity, generated −/− were repopulated a normal level syngeneic...
Multiple sclerosis (MS) is an increasingly prevalent progressive autoimmune and debilitating chronic disease that involves the detrimental recognition of central nervous system (CNS) antigens by immune system. Although significant progress has been made in last decades on biology MS identification novel therapies to treat its symptoms, etiology this remains unknown. However, recent studies have suggested viral infections may contribute onset. Interestingly, a potential association between...
Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair cognitive function of offspring. Previous studies have shown that maternal hypothyroidism increases severity experimental autoimmune encephalomyelitis (EAE), an disease model multiple sclerosis (MS). Here, we analyzed immune response after EAE induction in adult offspring gestated Hpx. Mice Hpx showed early appearance symptoms and...
Maternal thyroid hormones are essential for proper fetal development. A deficit of these during gestation has enduring consequences in the central nervous system offspring, including detrimental learning and impaired memory. Few studies have shown that hormone deficiency a transient effect number T B cells offspring gestated under hypothyroidism; however, there no showing whether maternal hypothyroidism impacts response to infections. In this study, we evaluated adult mice hypothyroid...
Gestational hypothyroxinemia (HTX) is a condition that occurs frequently at the beginning of pregnancy, and it correlates with cognitive impairment, autism, attentional deficit in offspring. Evidence animal models suggests gestational HTX can increase susceptibility offspring to develop strong inflammation immune-mediated inflammatory diseases. Ulcerative colitis (UC) frequent bowel disease unknown causes. Therefore, intensity ulcerative colitis-like disorder (UCLD) cellular molecular...