A5047284306- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Radiation Dose and Imaging
- Asthma and respiratory diseases
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Drug Transport and Resistance Mechanisms
- Prostate Cancer Treatment and Research
- Inhalation and Respiratory Drug Delivery
- Boron Compounds in Chemistry
- Chemical Reactions and Isotopes
- Orthopedic Infections and Treatments
- Peripheral Artery Disease Management
- Lymphatic System and Diseases
- Immune Response and Inflammation
- MRI in cancer diagnosis
- Chemotherapy-induced cardiotoxicity and mitigation
King's College London
2011-2024
St Thomas' Hospital
2009-2024
Guy's Hospital
2008-2024
Guy's and St Thomas' NHS Foundation Trust
2009-2024
St. Thomas Hospital
2006-2016
Royal Sussex County Hospital
2016
European Association of Nuclear Medicine
2013
Kings Health Partners
2013
University Hospitals Bristol NHS Foundation Trust
2013
Barnsley Hospital NHS Foundation Trust
2013
A method is described to monitor the motion of head during neurological positron emission tomography (PET) acquisitions and correct data post acquisition for recorded prior image reconstruction. The technique uses an optical tracking system, Polaris™, accurately position PET acquisition. are acquired in list mode where events written directly disk information aligned using a sequence pseudo-random numbers, which inserted into time tags event stream through gating input interface on...
The clinical value of current and future nanomedicines can be improved by introducing patient selection strategies based on noninvasive sensitive whole-body imaging techniques such as positron emission tomography (PET). Thus, a broad method to radiolabel track preformed liposomal drugs with PET radionuclides will have wide impact in nanomedicine. Here, we introduce simple efficient radiolabeling that exploits the metal-chelating properties certain (e.g., bisphosphonates alendronate...
High-resolution cardiac PET imaging with emphasis on quantification would benefit from eliminating the problem of respiratory movement during data acquisition. Respiratory gating basis list-mode has been employed previously as one approach to reduce motion effects. However, it results in poor count statistics degradation image quality. This work reports implementation a technique correct for area heart at no extra cost and potential maintain ECG gating, based rigid-body transformations...
Benchtop
Spectral analysis is a general modelling approach that enables calculation of parametric images from reconstructed tracer kinetic data independent an assumed compartmental structure. We investigated the validity applying spectral directly to projection motivated by advantages that: (i) number reconstructions reduced order magnitude and (ii) iterative reconstruction becomes practical which may improve signal-to-noise ratio (SNR). A dynamic software phantom with typical 2-[]thymidine kinetics...
Despite decades of effort aimed at developing clinically effective cell therapies, including mixed population mononuclear cells, to revascularize the ischemic limb, there remains a paucity patient-based studies that inform function and fate candidate types. In this study, we showed circulating proangiogenic/arteriogenic monocytes (PAMs) expressing FcγIIIA receptor CD16 were elevated in patients with chronic limb-threatening ischemia (CLTI), these amounts decreased after revascularization....
The ECAT EXACT3D (CTI/Siemens 966) 3D-only PET tomograph has unprecedented sensitivity due to the large BGO (bismuth germanate) detector volume. However, consequences of a (23.4 cm) axial field-of-view (FOV) and need for patient port diameter accommodate body scanning make device more sensitive photons arising from activity outside direct (coincidence) FOV. This leads relatively higher deadtime an increased registration random scatter (true) coincidences. purpose this study is determine...
Purpose: The Software for Tomographic Image Reconstruction (STIR, http://stir.sourceforge.net ) package is an open source object‐oriented library implemented in C++. Although its modular design suitable reconstructing data from several modalities, it currently only supports Positron Emission Tomography (PET) data. In this work, the authors present results Single Photon Computed (SPECT) imaging. Methods: This was achieved by complete integration of a 3D SPECT system matrix modeling into STIR....
By the time cardiotoxicity-associated cardiac dysfunction is detectable by echocardiography it often beyond meaningful intervention. 99mTc-sestamibi used clinically to image perfusion single photon emission computed tomography (SPECT) imaging, but as a lipophilic cation its distribution also governed mitochondrial membrane potential (ΔΨm). Correcting scans for variations in (using ΔΨm-independent tracer such (bis(N-ethoxy-N-ethyldithiocarbamato)nitrido 99mTc(V)) (99mTc-NOET) could allow be...
BackgroundIt is important to study differential inflammatory cellular migration, particularly of eosinophils and neutrophils, in asthma how this influenced by environmental stimuli such as allergen exposure the effects anti therapy.MethodsWe isolated blood neutrophils from 12 atopic asthmatic human volunteers (Group 1 — four Early Allergic Responders unchallenged (EAR); Group 2 Late (LAR) challenged; 3 EAR LAR challenged treated with systemic corticosteroids) using cGMP CD16 CliniMACS. Cells...
The aim of this paper is to report on experience with 3D positron emission tomography (PET) in our institute where we have three scanners, which two operate exclusively mode (ECAT ART, EXACT 3D). Fully PET requires attention a number factors are not as problematic 2D PET. Firstly, tomographs designed for whole-body acquisition suffer from large single-photon field view, extending well beyond the coincidence view. Single photons outside view increase dead time and random rates, contribute...
Iterative reconstruction with system response modelling has been implemented in commercial software by manufacturers for distance-dependent resolution (DRM) of the collimator physical effects. Initial experience such algorithms also shows improvements noise characteristics lower dependency on counting statistics. In this study performance one algorithm, Philips Astonish, was assessed bone single-photon emission computed tomography (SPECT) acquired at count levels reduced half technetium-99m...
Abstract Background Peptide receptor radionuclide therapy (PRRT) uses [ 177 Lu]Lu-[DOTA 0 -Tyr 3 ]octreotate ([ Lu]Lu-DOTA-TATE) to treat patients with neuroendocrine tumours (NETs) overexpressing the somatostatin 2A (SSTR2A). It has shown significant short-term improvements in survival and symptom alleviation, but there remains room for improvement. Here, we investigated whether combining Lu]Lu-DOTA-TATE chemotherapeutics enhanced vitro therapeutic efficacy of Lu]Lu-DOTA-TATE. Results...
Cell-based therapies using natural or genetically modified regulatory T cells (T(regs)) have shown significant promise as immune-based therapies. One of the main difficulties facing further advancement these is that fate and localization adoptively transferred T(regs) largely unknown. The ability to dissect migratory pathway in a non-invasive manner vital importance for development in-vivo cell-based immunotherapies, this technology allows therapeutically administered cell be imaged real...
The Nuclear Medicine Software Quality Group of the Institute Physics and Engineering in has conducted a multicentre, multivendor audit to evaluate use resolution recovery software from several manufacturers when applied myocardial perfusion data with half normal counts acquired under variety clinical protocols range departments. objective was determine whether centres could obtain results half-count processed that were equivalent those obtained using their protocols.Sixteen selected 50...