Alessandro Capone
A5101894022- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Nosocomial Infections in ICU
- Vibrio bacteria research studies
- Infective Endocarditis Diagnosis and Management
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Bacterial Infections and Vaccines
- Plant Pathogenic Bacteria Studies
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Bacillus and Francisella bacterial research
- Berberine and alkaloids research
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- Microscopic Colitis
- Poxvirus research and outbreaks
- Respiratory Support and Mechanisms
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2011-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
University of Pisa
2020
Sapienza University of Rome
2000
Ceftazidime-avibactam (CAZ-AVI) has been approved in Europe for the treatment of complicated intra-abdominal and urinary tract infections, as well hospital-acquired pneumonia, gram-negative infections with limited options. CAZ-AVI displays vitro activity against Klebsiella pneumoniae carbapenemase (KPC) enzyme producers, but clinical trial data on its efficacy this setting are lacking.We retrospectively reviewed 138 cases caused by KPC-producing K. (KPC-Kp) adults who received...
Abstract Background A growing body of observational evidence supports the value ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed data on use and outcomes CAZ-AVI therapy for Klebsiella pneumoniae carbapenemase–producing K. (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted propensity score receipt...
Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding the pathophysiology associated with COVID-19 is crucial to improve treatment modalities develop effective prevention strategies. Transcriptomic proteomic data on host response against still have anecdotic character; currently available from other coronavirus infections therefore a key source information.We investigated selected molecular aspects three human...
Background: Experience in real clinical practice with ceftazidime-avibactam for the treatment of serious infections due to gram−negative bacteria (GNB) other than carbapenem-resistant Enterobacterales (CRE) is very limited. Methods: We carried out a retrospective multicenter study patients hospitalized 13 Italian hospitals who received ≥72 h GNB CRE assess rates success, resistance development, and occurrence adverse events. Results: Ceftazidime-avibactam was used treat 41 CRE. Median age 62...
• COVID-19 patients have an exaggerated risk of acquiring BSI during ICU stay. The incidence ICU-acquired in is higher than that reported European ICUs the pre-COVID-19 period. commonest aetiological agents were intestinal commensals. A high rate acquisition VRE colonisation was observed.
Abstract Background Infections sustained by multidrug-resistant (MDR) and pan-resistant Acinetobacter baumannii have become a challenging problem in Intensive Care Units. Tigecycline provided new hope for the treatment of MDR A. infections, but isolates showing reduced susceptibility emerged many countries, further limiting therapeutic options. Empirical combination therapy has common practice to treat patients infected with , spite limited microbiological clinical evidence supporting its...
Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian producing OXA-24 carbapenemase. Both European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla(OXA-24) was part a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which other plasmids flank different modules, suggesting...
Abstract Background Few data are reported in the literature about outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated ceftolozane/tazobactam (C/T), empiric or definitive therapy. Methods A multicenter retrospective study was performed Italy (June 2016–June 2019). Successful clinical defined as complete resolution signs/symptoms related to ESBL-E infection and lack microbiological evidence infection. The primary end point...
To analyse the strains collected during a 1-year survey of ceftazidime-avibactam-resistant KPC-producing Klebsiella pneumoniae, in order to investigate molecular mechanisms potentially responsible for their resistant phenotype.Clinical K. pneumoniae isolates were from 31 patients six different hospitals Rome. For eight patients, an additional strain grown before start treatment was also available, bringing total studied 39. Antimicrobial susceptibility determined by automated system, broth...
ObjectivesInfections caused by multidrug-resistant (MDR) Acinetobacter baumannii are a challenging problem worldwide. Here, the molecular epidemiology and genetic basis of antibiotic resistance in 111 MDR A. strains isolated from June 2005 to March 2009 infected patients 10 intensive care units (ICUs) central Italy were investigated.
ObjectivesWe report the case of a kidney-transplant patient, suffering an intra-abdominal abscess at surgical site caused by carbapenem-resistant ST258 Klebsiella pneumoniae clone, producing KPC-3 carbapenemase. Under tigecycline treatment, patient developed sepsis carbapenem-susceptible K. strain. Complete DNA sequences plasmids carried resistant and susceptible strains from this were determined.
Background: Multi-drug-resistant Gram-negative bacteria producing metallo-β-lactamase are an increasing concern. Here, we described three cases of infection due to difficult-to-treat and drug-resistant P. aeruginosa metallo-β-lactamases, which were successfully treated with antibiotic combination cefiderocol plus imipenem-relebactam, reported on the molecular epidemiological features isolates in vitro synergistic effects different combinations guiding treatment. Patients methods: Three...
Aims: The aim of this study was to evaluate the in vitro activity doripenem (DOR) alone and combination with a variety commonly used anti-Acinetobacter chemotherapeutic agents against 22 primary multidrug-resistant (MDR) Acinetobacter baumannii isolates (including 17 that were resistant DOR) from Intensive Care Unit patients. Antibiotic interactions evaluated using chequerboard method time-kill assay. Results: Considering all antimicrobials DOR, analysis showed synergy 13 A. strains (54.2%)....
We describe the first isolation of an NDM-1-producing Pseudomonas aeruginosa in Italy. In May 2013, a patient with acute lymphoblastic leukaemia and history prior hospitalisation Belgrad, Serbia, underwent stem cell transplantation at tertiary care hospital Rome, After transplantion, sepsis by P. occurred, leading to septic shock fatal outcome.
Background: For years, Klebsiella pneumoniae carbapenemase (KPC)-producing K. have represented a serious health problem in hospitals worldwide. Since its approval 2015, ceftazidime-avibactam (CAZ-AVI) had been successfully used for treating complicated KPC-K. infections, until increasing reports of resistance began to emerge. Methods: Phenotypic tests and molecular analysis were performed four multidrug-resistant isolates, collected from two patients following treatment with CAZ-AVI....
Salmonella enterica ssp. arizonae is an uncommon human pathogen with serious infections reported in immunocompromised hosts. In Europe, only a few cases have been described. Patients this infection usually history of contact reptiles or travel abroad. We present case report patient hypoglobulinemia and literature review. describe the 43-year-old Caucasian Italian man who presented to our hospital sepsis diarrhea. A stool culture yielded S. arizonae. Our was treated oral ciprofloxacin made...
Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during 3-year surveillance program. blaKPC-3-carrying plasmids found belong the IncX3 group 9 11 strains, and complete nucleotide sequences obtained for 2 them. Our results highlight possible role C. as reservoir genes.