A5075632726- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Blood donation and transfusion practices
- Blood transfusion and management
- Anesthesia and Sedative Agents
- Renal Transplantation Outcomes and Treatments
- Hemodynamic Monitoring and Therapy
- Hepatitis C virus research
- Renal function and acid-base balance
- Viral-associated cancers and disorders
- Antifungal resistance and susceptibility
- Airway Management and Intubation Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Clinical Nutrition and Gastroenterology
- Antibiotics Pharmacokinetics and Efficacy
- Hepatocellular Carcinoma Treatment and Prognosis
- Antibiotic Resistance in Bacteria
- Organ Donation and Transplantation
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Polyomavirus and related diseases
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2016-2025
Ospedale Maggiore
1996-2023
University of Pisa
2019-2020
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019
Fundación Juan March
2016
Fresenius Kabi (Czechia)
2016
Creative Research Enterprises (United States)
2016
Astellas Pharma (United Kingdom)
2014
Université Libre de Bruxelles
2009
Vita-Salute San Raffaele University
1996
Ceftazidime-avibactam (CAZ-AVI) has been approved in Europe for the treatment of complicated intra-abdominal and urinary tract infections, as well hospital-acquired pneumonia, gram-negative infections with limited options. CAZ-AVI displays vitro activity against Klebsiella pneumoniae carbapenemase (KPC) enzyme producers, but clinical trial data on its efficacy this setting are lacking.We retrospectively reviewed 138 cases caused by KPC-producing K. (KPC-Kp) adults who received...
Abstract Background A growing body of observational evidence supports the value ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed data on use and outcomes CAZ-AVI therapy for Klebsiella pneumoniae carbapenemase–producing K. (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted propensity score receipt...
To investigate red blood cell rheology in a large intensive care unit population on admission, and to assess the possible influence of comorbidities rheology.: Prospective study.Medico-surgical with 31 beds.All admissions during 5-month period 20 healthy volunteers.Blood sampling.A total 196 patients (160 without 36 sepsis) volunteers were studied. Red (deformability aggregation) was assessed ex vivo using laser-assisted optical rotational analyzer (LORCA; Mechatronics Instruments BV, AN...
Abstract Introduction Hydroxyethyl starch (HES) is a commonly used colloid in critically ill patients. However, its safety has been questioned recent studies and meta-analyses. Methods We re-evaluated prospective randomised controlled trials (RCT) from four meta-analyses published 2013 that compared the effect of HES with crystalloids patients, focusing on adherence to 'presumably correct indication'. Regarding definition indication', were checked for following six criteria (maximum points):...
Background. Invasive fungal infection (IFI) following liver transplant is associated with significant morbidity and mortality. Antifungal prophylaxis rational for patients at high IFI risk. Methods. In this open-label, noninferiority study, were randomized 1:1 to receive intravenous micafungin 100 mg or center-specific standard care (fluconazole, liposomal amphotericin B, caspofungin) posttransplant. The primary endpoint was clinical success (absence of a proven/probable no need additional...
Maintenance of adequate immunosuppression and avoidance side-effects are the goals long-term management all organ-transplanted patients. We here report final results a prospective, randomized trial comparing early cyclosporine monotherapy versus double-drug therapy (cyclosporine steroids) in adult liver transplantation One hundred four patients were 3 months after either to continue (Group I = 50 patients) or stop steroids II 54 patients). Patients on regimen maintained long term...
The role of split-liver transplantation (SLT) for two adult recipients is still a matter debate, and no agreement exists on indications, surgical techniques, results. aim this study was to retrospectively analyze the outcome our series SLT. From May 1999 December 2006, 16 patients underwent SLT at unit. We used 9 full right grafts (segments 5-8) 7 left 1-4). splitting procedure always carried out in situ with fully perfused liver. Postoperative complications were recorded 8 (50%) patients: 5...
Management of biliary adverse events (BAEs) after biliodigestive anastomosis is challenging. We propose a new endoscopic approach to improve BAEs in this clinical setting.Patients who had hepaticojejunostomy with Roux-en-Y loop or Whipple procedure underwent creation an entero-enteral bypass (EEEB) between the duodenal/gastric wall and jejunal under ultrasound (EUS) fluoroscopic guidance using specifically designed fully covered self-expandable metal stents.32 consecutive patients EEEB,...