A5063223463- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ and Tissue Transplantation Research
- Diabetes Management and Research
- Liver Diseases and Immunity
- Renal Diseases and Glomerulopathies
- Blood groups and transfusion
- Complement system in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatic function and diabetes
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Metallurgy and Material Science
- Minimally Invasive Surgical Techniques
- Pulmonary Hypertension Research and Treatments
- Dermatological and COVID-19 studies
- Cancer Mechanisms and Therapy
- Macrophage Migration Inhibitory Factor
- Biliary and Gastrointestinal Fistulas
Regional Clinical Research
2017-2025
Moscow Regional Research Institute of Obstetrics and Gynecology
2016-2022
Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky
2017-2020
Association of Organ Procurement Organizations
2020
V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs
2008-2016
Sechenov University
2014
Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine
2010
Background. Invasive fungal infection (IFI) following liver transplant is associated with significant morbidity and mortality. Antifungal prophylaxis rational for patients at high IFI risk. Methods. In this open-label, noninferiority study, were randomized 1:1 to receive intravenous micafungin 100 mg or center-specific standard care (fluconazole, liposomal amphotericin B, caspofungin) posttransplant. The primary endpoint was clinical success (absence of a proven/probable no need additional...
Introduction. Resistant ascites after liver transplantation is a relatively rare complication. At the same time, its presence significantly affects prognosis and quality of life. Early diagnosis successful treatment resistant can improve long-term outcome. However, aetiology post-transplant heterogeneous, identification aetiological factor choice method in most cases significant problem for clinicians. Objective. To present review on methods recipients early posttransplant period. Material...
The availability of brain death donors is restricted by many factors. Use uncontrolled after cardiac could be a promising perspective, but the limiting factor in donation warm ischemic time. purpose our work was to develop an situ kidney preservation protocol with application extracorporal normothermic abdominal perfusion for organ resuscitation death. main attention paid elimination leukocytes as key damaging from modified donor oxygenated blood circulating device. In 2009, we had 10 time...
Introduction . Over the past few decades in Russia and other countries there has been signifi cant progress development of liver transplantation children. It became possible to operate recipients with very low body mass, perform transplant from cadaveric living donors incompatible blood type, as well single-step kidney or pancreas patients combined diseases. Aim: investigate 6-year experience children V.I. Shumakov Federal Research Center Transplantology Artifi cial Organs. Materials...
ТРАНСПЛАНТАЦИЯ ОРГАНОВ ДОНОРСТВО И В РОССИЙСКОЙ ФЕДЕРАЦИИ 2013 ГОДУ VI сообщение регистра Российского трансплантологического обществаГотье С
Aim of the study was to evaluate patient and graft survival after liver transplantation (LT) determine if primary disease diagnosis, early dysfunction or other factors affect it. Furthermore, we analyzed reasons short-term long-term deaths retransplantations. Materials methods . 192 LTs from donors with brain death were performed December 2004 until June 2014. Recipient age varied 5 71 years. Most frequent diagnosis cirrhosis (mainly due hepatitis C), then hepatocellular carcinoma (HCC),...
The unexploited potential of donors after cardiac death is an actual issue for all countries where organ transplantation performed. crucial point in uncontrolled donation the warm ischemic time. primary purpose our work was to define limits Another development situ kidney preservation protocol. In 8 with time from 45 91 minutes, a normothermic extracorporeal perfusion device applied, providing and restoration damage. Main attention paid elimination leukocytes as key damaging factor modified...
Aim. To carry out monitoring of the organization and development organ donation transplantation in Russian Federation according to 2014. Materials methods. Questioning heads all centers is carried out. The comparative analysis obtained data dynamics years, between certain regions Federation, centers, also with international registers made. Results. According Register 2014 functioned 36 kidney transplantation, 14 liver 9 heart transplantation. waiting list included 4636 potential recipients...
Monitoring of a condition and prospects organ donation transplantation development in Russia the form National Registry is carried out under auspices Pro fi le commission on transplantology Minis- try Health Russian Transplant Society. According to registry 2012 indicator do- nor activity decreased, but transplant remained at level last years. Decrease number deceased donors managed be compensated by means increase ef ciency donor programs: after brain death multi-organ explantation, average...
Cirrhotic cardiomyopathy is a syndrome, which includes systolic and diastolic dysfunction electrophysiological abnormalities in patients with liver cirrhosis the absence of any cardiac disease. Several mechanisms seem to be involved pathogenesis cirrhotic cardiomyopathy, such as impaired signaling beta-receptors, altered trans-membrane ion currents excess production vasodilators. Clinical manifestation non-specific usually masked by symptoms cirrhosis. Despite frequent regression after...
Aim. The aim of this study was to investigate late diabetic complications in patients with Type 1 diabetes mellitus (T1DM) who received simultaneous pancreas-kidney transplantation (SPK). Materials and Methods. included 16 T1DM SPK. All underwent clinical examination diagnostic investigation. Results. After SPK, 93.75% the had a functioning pancreas transplant, 100% kidney transplant within 4?48 months [mean 21 (10 is revealed; 36)). euglycaemia according daily monitoring. mean level...
Introduction. Impaired liver transplant function in the long term often leads to graft loss and recipient death. There are many causes for development of a late allograft dysfunction different types its clinical presentation, but there is no generally accepted definition. This hinders timely diagnosis, analysis prevalence, also makes it difficult compare performance transplantation programs. Objective. To determine prognostic value dysfunction. Material methods. The study included 103 cases...
Background. Benign recurrent intrahepatic cholestasis is a rare inherited disorder characterized by episodes of severe hyperbilirubinemia and pruritus that resolve spontaneously. However, attacks may persist for several months in some cases be associated with frequent recurrences, which grounds liver transplantation. Objective. To present clinical case debut benign following acute hepatitis A. Results. A 30-year-old patient was admitted at the Liver Transplantation Center Moscow Regional...
Introduction. The analysis of free circulating DNA (cfDNA) holds promise for molecular diagnostics, but its fragmentation and low concentration can complicate PCR analysis. Objective. To investigate the effect target length on amplification efficiency Y-chromosome markers from cfDNA. Material methods . Fifty cfDNA samples were obtained 39 patients: patients after liver transplantation (n=19), with acute leukemia allogeneic hematopoietic stem cell (n=10), pregnant women (n=10). In addition,...
To estimate short- and long-term outcomes of pediatric kidney transplants in Russia considering the maximum available number cases.Retrospective, observational, multi-center study included data about 1187 transplantation procedures (866 - deceased donor, 281 living donor 40 AB0-incompatible donor) performed 1065 patients (age 0-17 years) since 1990 till 2017. Patient graft survival, causes recipient deaths losses, as well as, influence type, blood group incompatibility age on were analyzed....
Aim: To present well-known and disputable mechanisms of the effects extracorporeal photopheresis (ECP) in heterogeneous clinical conditions, as well to demonstrate its advantages over conventional hormonal, immunosuppressive cytostatic treatments, with a recommendation widely implement it into practical management autoimmune disease cutaneous T-cell lymphomas (CTCLs). Key points: Despite convincing evidence ECP efficacy treatment mediated disorders, unifying concept mechanism has not been...
The shortage of donor organs results in the search for alternative ways to increase pool. One these is expansion marginal criteria. use liver grafts from donors this group associated with a high risk primary non-functioning graft which lies at basis ischemia-reperfusion injury liver. In regard, review, we examined main stages pathogenesis disturbances as well modern methods prevention and treatment.
Objective: to determine whether liver computed tomography (CT) perfusion imaging can assess hemodynamics in patients with fibrosis and cirrhosis as a result of chronic viral hepatitis C (CVHC). Subjects methods. The prospective study conducted at the Department Radiation Diagnosis, M.F. Vladimirsky Moscow Regional Research Clinical Institute, enrolled 61 CVHC, whom 26 had received antiviral therapy (AVT) achieved sustained virological response (SVR) 24 weeks after end treatment. All...
The web-based platform that allows to monitor recipients on-line was helpful in circumstances, where patients have no ability come for follow-ups as frequently it is required. Because of pandemia telemedicine consultations became not only additional service, but essential tool monitoring both transplanted end enlisted patients. TRANSPLANT.NET created collaboration with organization NEFRO-LIGA. This system physician control the current condition remotely. surveillance includes: 1) selective...
At present, it is widely recognized that machine perfusion allows for a decreased rate of delayed function the renal graft and risk liver early dysfunction. The aim review to present actual changes donor pool related prevailing numbers donors by expanded criteria, determine prospects expanding available based on their selection, as well development functional rehabilitation modification at tissue, cell molecular levels with help technologies. article presents state-of-the art view mechanisms...
Since 1999 living-donor kidney transplantation (LDKT) is one of the priorities in work our Center. More than 45% transplants performed annually are LDKTs. Long-term outcomes fi rst 357 LDKTs demonstrate good 10-year patient and graft survival: 93,5% 73,0%, respectively. In this group we identify risk factors poor age recipient less 18 years, duration dialysis before more 24 months creatinine level at discharge 130 mmol/L. The next step was introduction laparoscopic donor nephrectomy clinical...